Tannic acid-based sustained-release system for protein drugs
Open accessAbstract
In recent years, protein drug development has gained momentum, and simple and facile controlled-release systems without loss of activity are required. Herein, we developed a sustained-release system for protein drugs by exploiting the "astringency" mechanism, namely insoluble precipitate formation by interacting with tannic acid. Tannic acid formed insoluble precipitates with various protein drugs, such as nisin, insulin, lysozyme, ovalbumin, hyaluronidase, and human immunoglobulin G, through hydrophobic interactions and hydrogen bonds. The lysozyme/tannic acid complex retained in vitro lytic activity. Precipitates of the insulin/tannic acid complex prolonged hypoglycemic effects without loss of activity after subcutaneous administration. The ovalbumin/tannic acid complex enhanced anti-ovalbumin antibody production induced by ovalbumin, which may be attributed to its sustained-release profile. Accordingly, tannic acid is useful as a simple and user-friendly drug delivery system for protein drugs.
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The localized sustained-release antioxidant strategy facilitated by TA-GelMA mitigates adverse effects commonly associated with systemic administration and ensures a more prolonged and stable therapeutic action.
“Furthermore, the localized sustained-release antioxidant strategy facilitated by TA-GelMA mitigates the adverse effects commonly associated with systemic administration and ensures a more prolonged and stable therapeutic action51.”
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- Authors
- Utatsu, K., Motoyama, K., Nakamura, T., Onodera, R., & Higashi, T.
- Affiliations
- Kumamoto University (JP)
- Corresponding author
- Higashi, Taishi
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2023-08
- Volume
- 643
- Pages
- 123229
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W4384469705
- Cited by
- 31
- References
- 21
- Citations by year
- 2026: 15 · 2025: 7 · 2024: 8 · 2023: 1
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 355 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- International Journal of Pharmaceutics (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- Government of Japan Ministry of Education Culture Sports Science and Technology
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- tannic acid, protein drug delivery, sustained drug release, protein precipitation, lysozyme, insulin, ovalbumin, nisin, hyaluronidase, IgG, hydrophobic interactions, hydrogen bonding, subcutaneous administration, anti-ovalbumin antibodies
- MeSH terms
- Delayed-Action Preparations, Humans, Muramidase, Ovalbumin, Tannins, Polyphenols, Insulins
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