Hemispatial PCA dissociates temporal from parietal ERP generator patterns: CSD components in healthy adults and depressed patients during a dichotic oddball task
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Event-related potentials (31-channel ERPs) were recorded from 38 depressed, unmedicated outpatients and 26 healthy adults (all right-handed) in tonal and phonetic oddball tasks developed to exploit the perceptual challenge of a dichotic stimulation. Tonal nontargets were pairs of complex tones (corresponding to musical notes G and B above middle C) presented simultaneously to each ear (L/R) in an alternating series (G/B or B/G; 2-s fixed SOA). A target tone (note A) replaced one of the pair on 20% of the trials (A/B, G/A, B/A, A/G). Phonetic nontargets were L/R pairs of syllables (/ba/, /da/) with a short voice onset time (VOT), and targets contained a syllable (/ta/) with a long VOT. Subjects responded with a left or right button press to targets (counterbalanced across blocks). Target detection was poorer in patients than controls and for tones than syllables. Reference-free current source densities (CSDs; spherical spline Laplacian) derived from ERP waveforms were simplified and measured using temporal, covariance-based PCA followed by unrestricted Varimax rotation. Target-related N2 sinks and mid-parietal P3 sources were represented by CSD factors peaking at 245 and 440 ms. The P3 source topography included a secondary, left-lateralized temporal lobe maximum for both targets and nontargets. However, a subsequent hemispheric spatiotemporal PCA disentangled temporal lobe N1 and P3 sources as distinct factors. P3 sources were reduced in patients compared with controls, even after using performance as a covariate. Results are consistent with prior reports of P3 reduction in depression and implicate distinct parietal and temporal generators of P3 when using a dichotic oddball paradigm.
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Studies comparing oddball task performance often find that unmedicated major depressive disorder patients respond more slowly than healthy controls.
“Studies comparing oddball task performance by unmedicated MDD patients versus healthy controls often find that MDD patients respond more slowly than controls23–25, suggesting that even in the absence of overt distraction attentional focus is impaired.”
From Paying attention to attention in depression (2019) · cites this paper as [24]
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- Authors
- TENKE, C., KAYSER, J., SHANKMAN, S., GRIGGS, C., LEITE, P., STEWART, J., & BRUDER, G.
- Affiliations
- New York State Psychiatric Institute (US)
- University of Illinois Chicago (US)
- Corresponding author
- TENKE, C
- ORCID
- Venue
- International Journal of Psychophysiology
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 67
- Issue
- 1
- Pages
- 1-16
- ISSN
- 0167-8760 (ISSN-L)
- PMC
- PMC2271144
- OpenAlex
- W2088382156
- Cited by
- 35
- References
- 67
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Journal of Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH-50715, R01MH050715, MH36295, R01MH036295)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, event-related potentials, current source density, P300, N2 component, voice onset time
- MeSH terms
- Adult, Attention, Auditory Perception, Brain Mapping, Depressive Disorder, Dichotic Listening Tests, Discrimination, Psychological, Evoked Potentials, Auditory, Female, Humans, Functional Laterality, Male, Parietal Lobe, Phonetics, Reaction Time, Reference Values, Space Perception, Temporal Lobe, Case-Control Studies, Event-Related Potentials, P300, Principal Component Analysis
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