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Cited by 472Neurotransmitter Receptor Influence on BehaviorNeuroscience and Music PerceptionNeural and Behavioral Psychology Studies

Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: A new hypothesis

Hegerl, Ulrich, Juckel, Georg·1993·Biological Psychiatry
DOI 10.1016/0006-3223(93)90137-3
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Abstract

Because of the increasing importance of the central serotonergic neurotransmission for pathogenetic concepts and its role as a target of pharmacotherapeutic interventions in psychiatry, reliable indicators of this system are needed. It is proposed that the stimulus intensity dependence of auditory evoked N1/P2-component, which is probably modulated by cortical serotonergic innervation, may be a useful and noninvasive indicator of behaviorally relevant aspects of serotonergic activity. Converging evidence from our own studies as well as from the literature suggests that a pronounced intensity dependence of auditory evoked N1/P2-component reflects low central serotonergic neurotransmission. Recent findings concerning general functional aspects of the brain serotonin system reveal that this system is well qualified for adjusting individual levels of sensory processing ("set the tone"), especially in the primary auditory cortex in which the N1/P2-component is mainly generated. Dipole source analysis represents an important methodological advance in this context because it allows the separation of N1/P2-subcomponents generated in the primary auditory cortex from those generated in secondary auditory areas.

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Crossref · 10.1016/0006-3223(93)90137-3

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142 of 142 references verified0 citation errors · 0 not checkable

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  • The amplitude of the auditory N1 component is sensitive to sound intensity; loud sounds evoke larger N1 amplitudes than soft sounds.

    “The amplitude of this component is known to be sensitive to sound intensity; i.e., loud sounds evoke larger N1 amplitudes than soft sounds (Näätänen and Picton, 1987; Hegerl and Juckel, 1993).”

    From Neurophysiological evidence of efference copies to inner speech (2017) · cites this paper as Hegerl and Juckel, 1993

  • The amplitude of the N1 component is volume dependent: other things being equal, loud sounds evoke N1 components of larger amplitude than soft sounds.

    “The rationale for focusing on N1 lies in the fact that the amplitude of this component is volume dependent; that is, other things being equal, loud sounds evoke N1-components of larger amplitude than do soft sounds (Näätänen and Picton, 1987; Hegerl and Juckel, 1993).”

    From Neurophysiological evidence of efference copies to inner speech (2017) · cites this paper as Hegerl and Juckel, 1993

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Authors
Hegerl, U., & Juckel, G.
Affiliations
Freie Universität Berlin (DE)
Corresponding author
Hegerl, Ulrich
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1993-02
Volume
33
Issue
3
Pages
173-187
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/0006-3223(93)90137-3
OpenAlex
W2028129568
Cited by
472
References
148
Citations by year
2026: 3 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 11 · 2021: 35 · 2020: 17 · 2019: 12 · 2018: 6 · 2017: 14 · 2016: 18 · 2015: 12 · 2014: 18 · 2013: 15 · 2012: 15
FWCI
0.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
auditory evoked potentials, N1 and P2 components, stimulus intensity dependence, serotonin, primary auditory cortex, dipole source analysis, non-invasive biomarkers, sensory processing
MeSH terms
Arousal, Attention, Auditory Cortex, Auditory Pathways, Evoked Potentials, Auditory, Humans, Individuality, Loudness Perception, Synaptic Transmission, Serotonin

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