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Cited by 69Radiation Therapy and DosimetryEffects of Radiation ExposureAdvanced Radiotherapy Techniques

High Relative Biologic Effectiveness of Carbon Ion Radiation on Induction of Rat Mammary Carcinoma and its Lack of H-ras and Tp53 Mutations

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Imaoka, Tatsuhiko, Nishimura, Mayumi, Kakinuma, Shizuko, Hatano, Yukiko, Ohmachi, Yasushi, Yoshinaga, Shinji, Kawano, Akihiro, Maekawa, Akihiko +1 more·2007·International Journal of Radiation Oncology*Biology*Physics
DOI 10.1016/j.ijrobp.2007.05.026
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Abstract

Purpose The high relative biologic effectiveness (RBE) of high-linear energy transfer (LET) heavy-ion radiation has enabled powerful radiotherapy. The potential risk of later onset of secondary cancers, however, has not been adequately studied. We undertook the present study to clarify the RBE of therapeutic carbon ion radiation and molecular changes that occur in the rat mammary cancer model. Methods and materials We observed 7-8-week-old rats (ACI, F344, Wistar, and Sprague-Dawley) until 1 year of age after irradiation (0.05-2 Gy) with either 290 MeV/u carbon ions with a spread out Bragg peak (LET 40-90 keV/mum) generated from the Heavy-Ion Medical Accelerator in Chiba or (137)Cs gamma-rays. Results Carbon ions significantly induced mammary carcinomas in Sprague-Dawley rats but less so in other strains. The dose-effect relationship for carcinoma incidence in the Sprague-Dawley rats was concave downward, providing an RBE of 2 at a typical therapeutic dose per fraction. In contrast, approximately 10 should be considered for radiation protection at low doses. Immunohistochemically, 14 of 18 carcinomas were positive for estrogen receptor alpha. All carcinomas examined were free of common H-ras and Tp53 mutations. Importantly, lung metastasis (7%) was characteristic of carbon ion-irradiated rats. Conclusions We found clear genetic variability in the susceptibility to carbon ion-induced mammary carcinomas. The high RBE for carbon ion radiation further supports the importance of p…

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  • In mammary tumors, differences in tumor types comparing heavy ions to low LET radiation were observed, with more aggressive tumors observed.

    “Mammary tumors (Illa-Bochaca et al., 2014;Omene et al., 2020;Imaoka et al., 2007) Differences in mammary tumor types comparing heavy ions to low LET radiation with more aggressive tumors observed.”

    From A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection (2021) · cites this paper as Imaoka et al., 2007

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Authors
Imaoka, T., Nishimura, M., Kakinuma, S., Hatano, Y., Ohmachi, Y., Yoshinaga, S., Kawano, A., Maekawa, A., & Shimada, Y.
Affiliations
  • National Institute of Radiological Sciences (JP)
  • National Institute of Technology and Evaluation (JP)
Corresponding author
Imaoka, Tatsuhiko
ORCID
Venue
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier BV
Published
2007-09
Volume
69
Issue
1
Pages
194-203
ISSN
0360-3016 (ISSN-L)
DOI
10.1016/j.ijrobp.2007.05.026
OpenAlex
W2097343002
Cited by
69
References
4
Citations by year
2026: 5 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 2 · 2012: 5
FWCI
3.17
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Radiation Oncology*Biology*Physics (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
  • QST-Repository (National Institutes for Quantum and Radiological Science and Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
Keywords
carbon ion irradiation, heavy ion radiotherapy, breast cancer, HRAS mutation, TP53 mutation, estrogen receptor alpha, lung metastasis, spread-out Bragg peak, rat strain differences
MeSH terms
Animals, Carbon, Cesium Radioisotopes, Dose-Response Relationship, Radiation, Female, Mammary Neoplasms, Experimental, Neoplasm Proteins, Neoplasms, Hormone-Dependent, Neoplasms, Radiation-Induced, Radiation Protection, Genes, ras, Rats, Inbred ACI, Rats, Inbred F344, Receptors, Estrogen, Relative Biological Effectiveness, Species Specificity, Genes, p53, Rats, Sprague-Dawley, Rats, Wistar, Point Mutation, Linear Energy Transfer, Genetic Predisposition to Disease, Heavy Ions, Rats

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