Tumorigenic Potential of High-Z, High-LET Charged-Particle Radiations
Abstract
The potential for radiogenic neoplasia from charged-particle irradiation has been estimated using the Harderian gland of the mouse as a test system. Particles ranging in Z from Z = 1 (proton) to Z = 41 (niobium), in energy from 228 to 670A MeV, and in LET from 0.4 to 464 keV/microns were produced at the Lawrence Berkeley Laboratory BEVALAC. Expression of the tumorigenic potential of the initiated cells was enhanced by hormones from isogeneic grafts of pituitaries. The goal of the studies was to estimate the initial slope of the relationship between increased tumor prevalence at 16 months after irradiation and the dose received. Initial slopes were measured with good precision for 60Co gamma rays and the Bragg plateau beams of 228A MeV 4He ions, 600A MeV 56Fe ions, and 350A MeV 56Fe ions. The ratio of the initial slope for these ions to that of 60Co gamma rays give an estimate of the maximum RBE for radiogenic neoplasia. These values were 2.3 for the 4He ions, 40 for 600A MeV 56Fe, and 20 for 350A MeV 56Fe. In the studies reported here the prevalence of tumors as the result of pituitary isografts was not enhanced after irradiation with 56Fe ions. It remains to be seen how effective pituitary isografts are for enhancement of radiogenic neoplasia from other ions at different LET values. A risk analysis was undertaken using particle fluence rather than dose as the independent variable. This analysis provides a value for a "cross section" expressed in microns 2. This parameter exp…
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In Harderian gland tumors in B6CF1 female mice, the dose response for Fe particles was qualitatively different from γ-rays.
“Harderian Gland Tumors in B6CF1 female mice (Chang et al., 2016;Fry et al., 1985;Alpen et al., 1993) Dose response for Fe particles was qualitatively different from γ-rays.”
From A proposed change to astronaut exposures limits is a giant leap backwards for radiation protection (2021) · cites this paper as Alpen et al., 1993
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- Authors
- Alpen, E. L., Powers-Risius, P., Curtis, S. B., & DeGuzman, R.
- Affiliations
- Lawrence Berkeley National Laboratory (US)
- ORCID
- Curtis, S. B.
- Venue
- Radiation Research
- Publisher
- JSTOR
- Published
- 1993-12
- Volume
- 136
- Issue
- 3
- Pages
- 382
- ISSN
- 0033-7587 (ISSN-L)
- OpenAlex
- W2314026050
- Cited by
- 178
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 1
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- high-LET radiation, charged particle irradiation, tumorigenicity, relative biological effectiveness, iron ions, helium ions, particle fluence, risk coefficient, cross sections, dose-response slope
- MeSH terms
- Animals, Dose-Response Relationship, Radiation, Energy Transfer, Eye Neoplasms, Female, Gamma Rays, Harderian Gland, Helium, Iron, Lacrimal Apparatus Diseases, Mice, Inbred BALB C, Mice, Inbred C57BL, Neoplasms, Radiation-Induced, Pituitary Gland, Relative Biological Effectiveness, Transplantation, Isogeneic, Mice
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