The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Maximizing Tumor Immunity With Fractionated Radiation
Open accessAbstract
PURPOSE Technological advances have led to increased clinical use of higher sized fractions of radiation dose and higher total doses. How these modify the pathways involved in tumor cell death, normal tissue response, and signaling to the immune system has been inadequately explored. Here we ask how radiation dose and fraction size affect anti-tumor immunity, the suppression thereof and how this might relate to tumor control. MATERIALS and METHODS Mice bearing B16-OVA murine melanoma were treated with up to 15Gy radiation given in various sized fractions and tumor growth followed. The tumor-specific immune response in the spleen was assessed by IFNγ-Enzyme-Linked Immuno-Spot (ELISPOT) assay with ovalbumin (OVA) as the surrogate tumor antigen and the contribution of regulatory T cells (Tregs) determined by the proportion of CD4+CD25hiFoxp3+ T cells. RESULTS After single doses, tumor control increased with the size of radiation dose, as did the number of tumor-reactive T cells. This was offset at the highest dose by an increase in Treg representation. Fractionated treatment with medium-size radiation doses of 7.5Gy/fraction gave the best tumor control and tumor immunity while maintaining low Treg numbers. CONCLUSIONS Radiation can be an immune adjuvant but the response varies with the size of dose per fraction. The ultimate challenge is to optimally integrate cancer immunotherapy into radiation therapy.
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Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
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Radiation-Induced IFN-γ Production within the Tumor Microenvironment Influences Antitumor Immunity
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Radiation Enhances Regulatory T Cell Representation
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Self-citationA Sense of Danger from Radiation1
McBride, W. H., Chiang, C.-S., Olson, J. L., Wang, C.-C., Hong, J.-H., Pajonk, F., Dougherty, G. J., Iwamoto, K. S., Pervan, M., & Liao, Y.-P. (2004) · Radiation Research · doi:10.1667/rr3196 · Cited by 323
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Dovedi, S. J., Adlard, A. L., Lipowska-Bhalla, G., McKenna, C., Jones, S., Cheadle, E. J., Stratford, I. J., Poon, E., Morrow, M., Stewart, R., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1258 · Cited by 1,313
Cancer nanomedicine for combination cancer immunotherapy
Nam, J., Son, S., Park, K. S., Zou, W., Shea, L. D., & Moon, J. J. (2019) · Nature Reviews Materials · doi:10.1038/s41578-019-0108-1 · Cited by 940
Opportunities and challenges of radiotherapy for treating cancer
Schaue, D., & McBride, W. H. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.120 · Cited by 784
Self-citationSharabi, A. B., Nirschl, C. J., Kochel, C. M., Nirschl, T. R., Francica, B. J., Velarde, E., Deweese, T. L., & Drake, C. G. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0196 · Cited by 658
Luke, J. J., Lemons, J. M., Karrison, T. G., Pitroda, S. P., Melotek, J. M., Zha, Y., Al-Hallaq, H. A., Arina, A., Khodarev, N. N., Janisch, L., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.2229 · Cited by 588
Metadata
- Authors
- Schaue, D., Ratikan, J. A., Iwamoto, K. S., & McBride, W. H.
- Venue
- International Journal of Radiation Oncology*Biology*Physics
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 83
- Issue
- 4
- Pages
- 1306-1310
- ISSN
- 0360-3016 (ISSN-L)
- OpenAlex
- W2001816519
- Cited by
- 567
- References
- 17
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- green
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