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Cited by 429

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Radiation Enhances Regulatory T Cell Representation

Open access
Kachikwu, Evelyn L., Iwamoto, Keisuke S., Liao, Yu-Pei, DeMarco, John J., Agazaryan, Nzhde, Economou, James S., McBride, William H., Schaue, Dörthe·2011·International Journal of Radiation Oncology*Biology*Physics
DOI 10.1016/j.ijrobp.2010.09.034
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Abstract

PURPOSE Immunotherapy (IT) could be a useful adjunct to standard cytotoxic therapies such as radiation in patients with micrometastatic disease although successful integration of IT into treatment protocols will require further understanding of how standard therapies affect the generation of anti-tumor immune responses. This study was undertaken to evaluate the impact of radiation therapy on immunosuppressive T regulatory (Treg) cells. MATERIALS and METHODS Tregs were identified as a CD4+CD25hiFoxp3+ lymphocyte subset and their fate followed in a murine TRAMP-C1 model of prostate cancer in mice with and without radiation therapy. RESULTS CD4+CD25hiFoxp3+ Treg cells increased in immune organs following local leg or whole body radiation. A large part, but not all, of this increase following leg-only irradiation could be ascribed to radiation scatter and Tregs being intrinsically more radiation resistant than other lymphocyte subpopulations resulting in their selection. Their functional activity on a per cell basis was not affected by radiation exposure. Similar findings were made with mice receiving local RT to murine prostate tumors growing in the leg. The importance of the Treg population in the response to RT was shown by systemic elimination of Tregs, which greatly enhanced radiation-induced tumor regression. CONCLUSIONS We conclude that Tregs are more resistant to radiation than other lymphocytes resulting in their preferential increase. Treg cells may form an important homeostatic mechanism for tissues injured by radiation, and in a tumor context may assist in immune evasion during therapy. Targeting this population may allow enhancement of radiotherapeutic benefit through immune modulation.

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Metadata

Authors
Kachikwu, E. L., Iwamoto, K. S., Liao, Y.-P., DeMarco, J. J., Agazaryan, N., Economou, J. S., McBride, W. H., & Schaue, D.
Venue
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier BV
Published
2011-11
Volume
81
Issue
4
Pages
1128-1135
ISSN
0360-3016 (ISSN-L)
DOI
10.1016/j.ijrobp.2010.09.034
OpenAlex
W2168244200
Cited by
429
References
31
FWCI
3.51
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Radiation Enhances Regulatory T Cell Representation. https://app.cochat.ai/papers/10.1016/j.ijrobp.2010.09.034
The paper
Kachikwu, E. L., Iwamoto, K. S., Liao, Y.-P., DeMarco, J. J., Agazaryan, N., Economou, J. S., McBride, W. H., & Schaue, D. (2011). Radiation Enhances Regulatory T Cell Representation. International Journal of Radiation Oncology*Biology*Physics. https://doi.org/10.1016/j.ijrobp.2010.09.034

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.