The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Systemic effects of local radiotherapy
Open accessAbstract
SUMMARY Radiotherapy is generally used to treat a localized target that includes cancer. Mounting evidence indicates that radiotherapy also recruits biological effectors outside the treatment field, and has systemic effects. The implications of this aspect are discussed in this review, in the context of understanding the role of the host’s immune system in cooperating with standard cytotoxic treatments. Since effects from both chemotherapy and radiotherapy are sensed by the immune system, their combination with immunotherapy presents a new therapeutic opportunity. Radiotherapy carries the advantage of directly interfering with the primary tumor site, and potentially reverting some of the established immuno-supressive barriers present within the tumor microenvironment, ideally recovering the role of the primary tumor as an effective immunogenic hub. Local radiation also triggers systemic effects that can be harnessed in combination with immunotherapy to induce responses outside the radiation field. This review will cover some of the preclinical and clinical evidence in this regard.
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Cites
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Cited by
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Radiotherapy induces responses of lung cancer to CTLA-4 blockade
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Self-citationRadiation fosters dose-dependent and chemotherapy-induced immunogenic cell death
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Metadata
- Authors
- Formenti, S. C., & Demaria, S.
- Venue
- The Lancet Oncology
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 10
- Issue
- 7
- Pages
- 718-726
- ISSN
- 1470-2045 (ISSN-L)
- OpenAlex
- W2133739473
- Cited by
- 1,021
- References
- 70
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- green
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