Cited by 153Advanced Radiotherapy TechniquesRadiation Therapy and DosimetryEffects of Radiation Exposure

High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic (HyTEC): an overview

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Grimm, Jimm, Marks, Lawrence B., Jackson, Andrew, Kavanagh, Brian D., Xue, Jinyu, Yorke, Ellen·2021·International Journal of Radiation Oncology*Biology*Physics

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Crossref · 10.1016/j.ijrobp.2020.10.039

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  • A seminal paper by Emami et al. summarized normal-tissue tolerances to external photon irradiation as they were known in 1991, and these data have been gradually updated and expanded through QUANTEC and HyTEC.

    “A seminal paper by Emami et al. ( 6 ) summarized normal-tissue tolerances to external photon irradiation as they were known in 1991, and these data have been gradually updated and expanded through other initiatives such as Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) and Hypofractionated Treatment Effects in the Clinic (HyTEC) ( 25 , 26 ).”

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  1. [25]Holmes G Some experiments in standardization of dosage for Roentgen therapeutics. Am J Röentgenol 1914; 1: 298– 302.
  2. [26]Tsuzuki M Experimental studies on the biological action of hard Roentgen Rays. Am J Röentgenol 1926; 16: 134– 150.
  3. [27]Failla G, Quimby EH, Dean AL. Some problems in radiation therapy. Am J Roentgenol 1922; 9: 479.
  4. [29]Holthusen H Erfahrungen über die Verträglichkeitsgrenze für Rönt-genstrahlen and deren Nutzanwendung zur Verhütung von Schäden [Experiences on the tolerability limit for X-rays and practical application for the prevention of damage]. Strahlentherapie 1936; 57: 254– 269.

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Authors
Grimm, J., Marks, L. B., Jackson, A., Kavanagh, B. D., Xue, J., & Yorke, E.
Affiliations
  • Geisinger Medical Center (US)
  • University of North Carolina at Chapel Hill (US)
  • Memorial Sloan Kettering Cancer Center (US)
  • University of Colorado Anschutz (US)
  • NYU Langone Health (US)
Corresponding author
Grimm, Jimm
Venue
International Journal of Radiation Oncology*Biology*Physics
Publisher
Elsevier BV
Published
2021-05
Volume
110
Issue
1
Pages
1-10
ISSN
0360-3016 (ISSN-L)
OpenAlex
W3155614206
Cited by
153
References
46
Citations by year
2026: 28 · 2025: 28 · 2024: 42 · 2023: 24 · 2022: 21 · 2021: 10
FWCI
17.69
Type
journal article
Language
en
Open access
Locations
  • International Journal of Radiation Oncology*Biology*Physics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute
  • National Institutes of Health (P30 CA008748)
Topics
  • Physical Sciences › Physics and Astronomy › Radiation › Advanced Radiotherapy Techniques
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Keywords
hypofractionated radiotherapy, high-dose per fraction, stereotactic radiosurgery, stereotactic body radiotherapy, normal tissue complication probability, QUANTEC, HYTEC, normal tissue effects
MeSH terms
Radiation Dose Hypofractionation, Systematic Reviews as Topic, Age Factors, Dose-Response Relationship, Radiation, Humans, Neoplasms, Organ Specificity, Radiotherapy Planning, Computer-Assisted, Radiosurgery, Practice Guidelines as Topic, Organs at Risk

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