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MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C/EBP-α pathway in intracerebral hemorrhage

Yu, Anyong, Zhang, Tianxi, Duan, Haizhen, Pan, Yong, Zhang, Xiaojun, Yang, Guang, Wang, Juan, Deng, Yi, Yang, Zhao·2017·Immunology Letters
DOI 10.1016/j.imlet.2016.12.003
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Abstract

Microglia mediated inflammation contributes to intracerebral hemorrhage (ICH) induced secondary injury. Activated microglia has dual functions as pro-inflammatory (M1) and anti-inflammatory (M2) factors in brain injury and repair. MiR-124 is a potent anti-inflammatory agent which affects microglia after brain injury. However, the potential of modulating the M1/M2 polarization of microglia after ICH has not been reported. In this experiment, we detected the effect of miR-124 on the M1/M2 polarization state. In addition, the ability miR-124 to subsequently impacted neurological deficit and cerebral water content of ICH mice were studied. Furthermore, the relationship between miR-124 and C/EBP-α target was detected. We found that miR-124 significantly increased in M2-polarized microglia. Transduction of miR-124 mimics decreased proinflammatory cytokine levels. A coculture model of microglia and neuron indicated that M2-polarized microglia protected neuron damage. Furthermore, miR-124 banded to the 3-untranslated region of C/EBP-α and downregulated its protein levels. In vivo, infusion of miR-124 decreased brain levels of C/EBP-α and significantly reduced brain injury in ICH mice. Thus, miR-124 ameliorated ICH-induced inflammatory injury by modulating microglia polarization toward the M2 phenotype via C/EBP-α. MiR-124 regulatory mechanisms also might represent new therapeutic strategy in ICH.

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Research works printed but not linked: 42

  1. Bonsack, 2016, Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation?, J. Neuroinflammation, 151, 10.1186/s12974-016-0619-2 · DOI
  2. Zheng, 2016, Mechanism and therapy of brain edema after intracerebral hemorrhage, Cerebrovasc. Dis. (Basel, Switzerland), 42, 155, 10.1159/000445170 · DOI
  3. Hsieh, 2016, Comparison of gender differences in intracerebral hemorrhage in a multi-Ethnic asian population, PLoS One, 11, e0152945, 10.1371/journal.pone.0152945 · DOI
  4. Tao, 2016, A novel brainstem hemorrhage model by autologous blood infusion in rat: white matter injury, magnetic resonance imaging, and neurobehavioral features, J. Stroke Cerebrovasc. Dis., 25, 1102, 10.1016/j.jstrokecerebrovasdis.2016.01.025 · DOI
  5. Guo, 2015, A case report of successful conservative treatment for huge acute traumatic intracerebral hematoma, Medicine (Baltimore)., 94, e656, 10.1097/MD.0000000000000656 · DOI
  6. Wei, 2011, Neuroprotection of selective brain cooling after penetrating ballistic-like brain injury in rats, Ther. Hypothermia Temp. Manage., 1, 33, 10.1089/ther.2010.0007 · DOI
  7. Zheng, 2015, Lithium posttreatment confers neuroprotection through glycogen synthase kinase-3beta inhibition in intracerebral hemorrhage rats, J. Neurosurg., 1
  8. Zhou, 2016, Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3beta/PTEN axis, J. Cereb. Blood Flow Metab., 5, 12
  9. Weng, 2015, N-methyl-D-aspartic acid receptor 1 (NMDAR1) aggravates secondary inflammatory damage induced by hemin-NLRP3 pathway after intracerebral hemorrhage, Chin. J. Traumatol.=Zhonghua chuang shang za zhi, 18, 254, 10.1016/j.cjtee.2015.11.010 · DOI
  10. Francos-Quijorna, 2016, IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury, Glia, 64, 2079, 10.1002/glia.23041 · DOI
  11. Lee, 2016, Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice, Neurobiol. Dis., 96, 248, 10.1016/j.nbd.2016.09.013 · DOI
  12. Shi, 2016, Sinomenine enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage, J. Neuroimmunol., 299, 28, 10.1016/j.jneuroim.2016.08.010 · DOI
  13. Xu, 2016, Methionine enkephalin regulates microglia polarization and function, Int. Immunopharmacol., 40, 90, 10.1016/j.intimp.2016.08.037 · DOI
  14. Plastira, 2016, 1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype, J. Neuroinflammation, 13, 205, 10.1186/s12974-016-0701-9 · DOI · Paper page
  15. Hamzei Taj, 2016, Dynamic modulation of microglia/macrophage polarization by miR-124 after focal cerebral ischemia, J. Neuroimmune Pharmacol., 11, 733, 10.1007/s11481-016-9700-y · DOI
  16. Haug, 2015, Exosome-like extracellular vesicles from MYCN-amplified neuroblastoma cells contain oncogenic miRNAs, Anticancer Res., 35, 2521
  17. Xue, 2015, Analysis of gene profiles in glioma cells identifies potential genes, miRNAs, and target sites of migratory cells, Tumori, 101, 542, 10.5301/tj.5000226 · DOI
  18. Veremeyko, 2013, IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation, PLoS One, 8, e81774, 10.1371/journal.pone.0081774 · DOI · Paper page
  19. Ponomarev, 2013, MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS, Glia, 61, 91, 10.1002/glia.22363 · DOI
  20. Willemen, 2012, MicroRNA-124 as a novel treatment for persistent hyperalgesia, J. Neuroinflammation, 9, 143, 10.1186/1742-2094-9-143 · DOI · Paper page
  21. Yuan, 2016, C5a/C5aR pathway plays a vital role in brain inflammatory injury via initiating Fgl-2 in intracerebral hemorrhage, Mol. Neurobiol., 12, 236
  22. Yu, 2016, IL-17A promotes microglial activation and neuroinflammation in mouse models of intracerebral haemorrhage, Mol. Immunol., 73, 151, 10.1016/j.molimm.2016.04.003 · DOI
  23. Wu, 2016, Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice, J. Cereb. Blood Flow Metab., 10, 56
  24. Zhang, 2015, Activation of dopamine D2 receptor suppresses neuroinflammation through alphaB-crystalline by inhibition of NF-kappaB nuclear translocation in experimental ICH mice model, Stroke J. Cereb. Circ., 46, 2637, 10.1161/STROKEAHA.115.009792 · DOI
  25. Leclerc, 2015, Intracerebral hemorrhage outcomes following selective blockade or stimulation of the PGE2 EP1 receptor, BMC Neurosci., 16, 48, 10.1186/s12868-015-0182-2 · DOI
  26. Piotrowska, 2016, Maraviroc reduces neuropathic pain through polarization of microglia and astroglia − evidence from in vivo and in vitro studies, Neuropharmacology, 108, 207, 10.1016/j.neuropharm.2016.04.024 · DOI
  27. Weng, 2016, Malibatol A enhances alternative activation of microglia by inhibiting phosphorylation of mammalian Ste20-like kinase1 in OGD-BV-2 cells, Neurol. Res., 38, 342, 10.1080/01616412.2016.1174423 · DOI
  28. Hernandez-Rabaza, 2016, Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia, J. Neuroinflammation, 13, 83, 10.1186/s12974-016-0549-z · DOI
  29. Wan, 2016, Microglia activation and polarization after intracerebral hemorrhage in mice: the role of protease-Activated receptor-1, Trans. Stroke Res., 7, 478, 10.1007/s12975-016-0472-8 · DOI
  30. Xiong, 2016, Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke, Prog. Neurobiol., 142, 23, 10.1016/j.pneurobio.2016.05.001 · DOI
  31. Ransohoff, 2016, A polarizing question: do M1 and M2 microglia exist?, Nat. Neurosci., 19, 987, 10.1038/nn.4338 · DOI · Paper page
  32. Wang, 2016, scAAV9-VEGF prolongs the survival of transgenic ALS mice by promoting activation of M2 microglia and the PI3K/Akt pathway, Brain Res., 1648, 1, 10.1016/j.brainres.2016.06.043 · DOI
  33. Li, 2016, mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type, FASEB J., 30, 3388, 10.1096/fj.201600495R · DOI
  34. Meng, 2016, Neuronal soluble fas ligand drives M1-microglia polarization after cerebral ischemia, CNS Neurosci. Ther., 22, 771, 10.1111/cns.12575 · DOI
  35. Arroba, 2016, Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice, Biochim. Biophys. Acta, 1862, 1663, 10.1016/j.bbadis.2016.05.024 · DOI
  36. Esslinger, 2016, Schizophrenia associated sensory gating deficits develop after adolescent microglia activation, Brain Behav. Immun., 58, 99, 10.1016/j.bbi.2016.05.018 · DOI
  37. Zhuang, 2012, A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation, Circulation, 125, 2892, 10.1161/CIRCULATIONAHA.111.087817 · DOI · Paper page
  38. Rao, 2013, Ikaros limits basophil development by suppressing C/EBP-alpha expression, Blood, 122, 2572, 10.1182/blood-2013-04-494625 · DOI
  39. Regalo, 2010, C/EBP alpha expression is associated with homeostasis of the gastric epithelium and with gastric carcinogenesis, Lab. Investig. J. Tech. Methods Pathol., 90, 1132, 10.1038/labinvest.2010.79 · DOI
  40. Chase, 2014, Metabolic and inflammatory genes in schizophrenia, Psychiatry Res., 225, 208, 10.1016/j.psychres.2014.11.007 · DOI · Paper page
  41. Roth, 2009, An imbalance in C/EBPs and increased mitochondrial activity in asthmatic airway smooth muscle cells: novel targets in asthma therapy, Br. J. Pharmacol., 157, 334, 10.1111/j.1476-5381.2009.00188.x · DOI
  42. Chen, 2013, C/EBPalpha regulates osteoclast lineage commitment, Proc. Natl. Acad. Sci. U. S. A., 110, 7294, 10.1073/pnas.1211383110 · DOI

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Metadata

Authors
Yu, A., Zhang, T., Duan, H., Pan, Y., Zhang, X., Yang, G., Wang, J., Deng, Y., & Yang, Z.
Venue
Immunology Letters
Publisher
Elsevier BV
Published
2017-02
Volume
182
Pages
1-11
ISSN
0165-2478
DOI
10.1016/j.imlet.2016.12.003
Cited by
107
References
5
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
NSFC (81560217)

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