TCR Signal Strength Influences αβ/γδ Lineage Fate
Open accessAbstract
Signals transduced by T cell antigen receptors (TCRs) have been shown to be critical for alphabeta and gammadelta T cell development, but their role in lineage determination remains poorly defined. Two models have been forwarded for alphabeta/gammadelta lineage choice: the instructive model and the stochastic model. Recent data, however, are inconsistent with either model. In this study, we devised an experimental system in which lineage fate was controlled exclusively by the gammadeltaTCR. We then analyzed the impact of TCR signal strength on alphabeta/gammadelta lineage development by altering the surface expression or signaling potential of the gammadeltaTCR complex. We found that increasing the gammadeltaTCR signal strength favored gammadelta lineage development, whereas weakening the gammadeltaTCR signal favored alphabeta lineage development. These results support a model in which the strength of the TCR signal is a critical determinant in the lineage fate decision.
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Numerous signals impact γδ T cell lineage including TCR signal strength, notch signaling, IL-7R signaling, and the presence of DP thymocytes.
“Numerous signals impact on the γδ T cell lineage including, TCR signal strength, notch signaling, IL-7R signaling and the presence of DP thymocytes [6]–[10].”
From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [6]
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Ribeiro, S. T., Ribot, J. C., & Silva-Santos, B. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00015 · Cited by 116 · see citing works
The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis
Jabeen, R., Chang, H.-C., Goswami, R., Nutt, S. L., & Kaplan, M. H. (2011) · PLOS ONE · doi:10.1371/journal.pone.0022189 · Cited by 10 · see citing works
- Authors
- Hayes, S. M., Li, L., & Love, P. E.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Love, Paul E.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 22
- Issue
- 5
- Pages
- 583-593
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2078191138
- Cited by
- 288
- References
- 0
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 9 · 2023: 12 · 2022: 18 · 2021: 9 · 2020: 17 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 14 · 2014: 13 · 2013: 9 · 2012: 17
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- T cell receptor signaling, signal strength, alpha beta T cells, γδ T cells, T cell development, stochastic modeling, T cell receptor complex
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Humans, Mice, Inbred C57BL, Mice, Transgenic, Recombinant Proteins, Signal Transduction, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Antigen, T-Cell, alpha-beta, DNA, Complementary, Mice, Knockout, Models, Immunological, Mice, In Vitro Techniques
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