CD3(+)CD4(-)CD8(-) (Double-negative) T cells in inflammation, immune disorders and cancer

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia

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Six-of-the-best: unique contributions of γδ T cells to immunology

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Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

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The machinery of programmed cell death

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Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

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Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

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Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

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T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis.

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CD4/major histocompatibility complex class II interaction analyzed with CD4‐ and lymphocyte activation gene‐3 (LAG‐3)‐Ig fusion proteins

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Resident human hepatitis lymphocytes are phenotypically different from circulating lymphocytes

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Fas death receptor signalling: roles of Bid and XIAP

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Immune Cell Composition in Human Non-small Cell Lung Cancer

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The Role of IL-23/IL-17 Axis in Lupus Nephritis

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TCR Signal Strength Influences αβ/γδ Lineage Fate

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The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

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Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

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Isolation and characterization of human antigen-specific TCRαβ+ CD4-CD8- double-negative regulatory T cells

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Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

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The DNA Damage Response Arouses the Immune System

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Human TCR-αβ+ CD4− CD8− T Cells Can Derive from CD8+ T Cells and Display an Inflammatory Effector Phenotype

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Role of gamma-delta (γδ) T cells in autoimmunity

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Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors

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Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production

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α β and γ δ T cells can share a late common precursor

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New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses

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Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells

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The Immune Regulatory Function of Lymphoproliferative Double Negative T Cells In Vitro and In Vivo

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CD4/CD8 double-negative epidermotropic cutaneous T-cell lymphoma: An immunohistochemical variant of mycosis fungoides

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IL-17-producing CD4−CD8− T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjögren's syndrome

Alunno, A., Bistoni, O., Bartoloni, E., Caterbi, S., Bigerna, B., Tabarrini, A., Mannucci, R., Falini, B., & Gerli, R. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-201511 · Cited by 109 · see citing works

Lung CD4−CD8− Double-Negative T Cells Are Prominent Producers of IL-17A and IFN-γ during Primary Respiratory Murine Infection with Francisella tularensis Live Vaccine Strain

Cowley, S. C., Meierovics, A. I., Frelinger, J. A., Iwakura, Y., & Elkins, K. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000362 · Cited by 108 · see citing works

Characterization of the immunoregulatory function of human TCR‐αβ+ CD4−CD8− double‐negative T cells

Völkl, S., Gary, R., & Mackensen, A. (2011) · European Journal of Immunology · doi:10.1002/eji.201040982 · Cited by 105 · see citing works

Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms

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Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells

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Normal mouse kidneys contain activated and CD3+CD4−CD8− double-negative T lymphocytes with a distinct TCR repertoire

Ascon, D. B., Ascón, M. A., Satpute, S. R., López-Briones, S., Racusen, L. C., Colvin, R. B., Soloski, M. J., & Rabb, H. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0907651 · Cited by 99 · see citing works

TcR-α/β+ CD4−CD8− T Cells in Humans with the Autoimmune Lymphoproliferative Syndrome Express a Novel CD45 Isoform That Is Analogous to Murine B220 and Represents a Marker of Altered O-Glycan Biosynthesis

Bleesing, J., Brown, M. R., Dale, J. K., Straus, S. E., Lenardo, M. J., Puck, J. M., Atkinson, T. P., & Fleisher, T. A. (2001) · Clinical Immunology · doi:10.1006/clim.2001.5069 · Cited by 91 · see citing works

Tumor-infiltrating lymphocytes (TILs) from patients with glioma

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TCR/Self-Antigen Interactions Drive Double-Negative T Cell Peripheral Expansion and Differentiation into Suppressor Cells

Priatel, J. J., Utting, O., & Teh, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6188 · Cited by 88 · see citing works

Double-Negative αβ T Cells Are Early Responders to AKI and Are Found in Human Kidney

Martina, M. N., Noel, S., Saxena, A., Bandapalle, S., Majithia, R., Jie, C., Arend, L. J., Allaf, M. E., Rabb, H., & Hamad, A. R. A. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014121214 · Cited by 86 · see citing works

Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells

Milush, J. M., Mir, K. D., Sundaravaradan, V., Gordon, S. N., Engram, J. C., Cano, C. A., Reeves, J. D., Anton, E. D., O’Neill, E., Butler, E. N., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44876 · Cited by 83 · see citing works

Double Negative (DN) αβ T Cells: misperception and overdue recognition

Martina, M. N., Noel, S., Saxena, A., Rabb, H., & Hamad, A. R. A. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.99 · Cited by 83 · see citing works

A Composite Picture of TcRα/β+ CD4−CD8− T Cells (α/β-DNTCs) in Humans with Autoimmune Lymphoproliferative Syndrome

Bleesing, J., Brown, M. R., Novicio, C., Guarraia, D., Dale, J. K., Straus, S. E., & Fleisher, T. A. (2002) · Clinical Immunology · doi:10.1006/clim.2002.5225 · Cited by 81 · see citing works

CD4−CD8− T-cells in primary Sjögren's syndrome: Association with the extent of glandular involvement

Alunno, A., Carubbi, F., Bistoni, O., Caterbi, S., Bartoloni, E., Bigerna, B., Pacini, R., Beghelli, D., Cipriani, P., Giacomelli, R., et al. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.01.030 · Cited by 78 · see citing works

Double-Negative T Cells, Activated by Xenoantigen, Lyse Autologous B and T Cells Using a Perforin/Granzyme-Dependent, Fas-Fas Ligand-Independent Pathway

Zhang, Z., Ma, Y., Wang, H., Arp, J., Jiang, J., Huang, X., He, K. M., Garcia, B. M., Madrenas, J., & Zhong, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.6920 · Cited by 78 · see citing works

Human TCR α/β+ CD4−CD8− Double-Negative T Cells in Patients with Autoimmune Lymphoproliferative Syndrome Express Restricted Vβ TCR Diversity and Are Clonally Related to CD8+ T Cells

Bristeau-Leprince, A., Mateo, V., Lim, A., Magérus, A., Solary, É., Fischer, A., Rieux‐Laucat, F., & Gougeon, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.440 · Cited by 77 · see citing works

Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15

Yao, J., Ly, D., Dervovic, D., Fang, L., Lee, J. B., Kang, H., Wang, Y., Pham, N., Pan, H., Tsao, M., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0507-2 · Cited by 75 · see citing works

TCR Ligation on CD8+ T Cells Creates Double-Negative Cells In Vivo

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Overexpressed Ly-6A.2 mediates cell-cell adhesion by binding a ligand expressed on lymphoid cells.

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Disparate Immunoregulatory Potentials for Double-Negative (CD4−CD8−) αβ and γδ T Cells from Human Patients with Cutaneous Leishmaniasis

Antonelli, L. R. D. V., Dutra, W. O., Oliveira, R. R., Torres, K., Guimarães, L. H., Bacellar, O., & Gollob, K. J. (2006) · Infection and Immunity · doi:10.1128/iai.00890-06 · Cited by 74 · see citing works

Cutting Edge: In Vivo Trogocytosis as a Mechanism of Double Negative Regulatory T Cell-Mediated Antigen-Specific Suppression

McIntyre, M. S. F., Young, K. J., Gao, J. F., Joe, B., & Zhang, L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2271 · Cited by 69 · see citing works

Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer

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A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy

DeMaster, L. K., Liu, X., VanBelzen, J., Trinité, B., Zheng, L., Agosto, L. M., Migueles, S. A., Connors, M., Sambucetti, L. C., Levy, D. N., et al. (2015) · Journal of Virology · doi:10.1128/jvi.01913-15 · Cited by 68 · see citing works

Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma

Tian, D., Yang, L., Wang, S., Zhu, Y., Shi, W., Zhang, C., Jin, H., Tian, Y., Xu, H., Sun, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12243-0 · Cited by 68 · see citing works

CD4-Like Immunological Function by CD4 − T Cells in Multiple Natural Hosts of Simian Immunodeficiency Virus

Vinton, C. L., Klatt, N. R., Harris, L. D., Briant, J. A., Sanders-Beer, B. E., Herbert, R. L., Woodward, R. A., Silvestri, G., Pandrea, I., Apetrei, C., et al. (2011) · Journal of Virology · doi:10.1128/jvi.00332-11 · Cited by 67 · see citing works

Targeting chemotherapy-resistant leukemia by combining DNT cellular therapy with conventional chemotherapy

Chen, B., Lee, J. B., Kang, H., Minden, M. D., & Li, Z. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0756-9 · Cited by 67 · see citing works

Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade

Fang, L., Ly, D., Wang, S., Lee, J. B., Kang, H., Xu, H., Yao, J., Tsao, M., Liu, W., & Li, Z. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1126-y · Cited by 67 · see citing works

Transcriptome landscape of double negative T cells by single-cell RNA sequencing

Yang, L., Zhu, Y., Tian, D., Wang, S., Guo, J., Sun, G., Jin, H., Zhang, C., Shi, W., Gershwin, M. E., et al. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102653 · Cited by 66 · see citing works

Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy

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Donor Lymphocyte Infusion Induces Long-Term Donor-Specific Cardiac Xenograft Survival through Activation of Recipient Double-Negative Regulatory T Cells

Chen, W., Zhou, D., Torrealba, J. R., Waddell, T. K., Grant, D. R., & Li, Z. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3409 · Cited by 65 · see citing works

Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency

Rensing‐Ehl, A., Völkl, S., Speckmann, C., Lorenz, M. R., Ritter, J. M., Janda, A., Abinun, M., Pircher, H., Bengsch, B., Thimme, R., et al. (2014) · Blood · doi:10.1182/blood-2014-03-564286 · Cited by 64 · see citing works

Level of double negative T cells, which produce TGF-β and IL-10, predicts CD8 T-cell activation in primary HIV-1 infection

Petitjean, G., Chevalier, M. F., Tibaoui, F., Didier, C., Manea, M. E., Liovat, A.-S., Campa, P., Müller-Trutwin, M. C., Girard, P., Meyer, L., et al. (2011) · AIDS · doi:10.1097/qad.0b013e32834e1484 · Cited by 63 · see citing works

Peptide‐activated double‐negative T cells can prevent autoimmune type‐1 diabetes development

Ford, M. S., Chen, W., Wong, S., Li, C., Vanama, R., Elford, A. R., Asa, S. L., Ohashi, P. S., & Zhang, L. (2007) · European Journal of Immunology · doi:10.1002/eji.200636991 · Cited by 63 · see citing works

Double-Negative T Regulatory Cells Can Develop Outside the Thymus and Do Not Mature from CD8+ T Cell Precursors

Ford, M. S., Zhang, Z., Chen, W., & Zhang, L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2803 · Cited by 62 · see citing works

Double‐negative regulatory T cells induce allotolerance when expanded after allogeneic haematopoietic stem cell transplantation

McIver, Z. A., Serio, B., Dunbar, A. J., O'Keefe, C., Powers, J., Włodarski, M. W., Jin, T., Sobecks, R. M., Bolwell, B. J., & Maciejewski, J. P. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07021.x · Cited by 60 · see citing works

Regulation of antigen‐expressing dendritic cells by double negative regulatory T cells

Gao, J. F., McIntyre, M. S. F., Juvet, S., Diao, J., Li, X., Vanama, R., Mak, T. W., Cattral, M. S., & Zhang, L. (2011) · European Journal of Immunology · doi:10.1002/eji.201141428 · Cited by 60 · see citing works

TCR + CD3 + CD4 − CD8 − effector T cells in psoriasis

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Unique T-Cell Populations Define Immune-Inflamed Hepatocellular Carcinoma

Blasi, D. D., Boldanova, T., Mori, L., Terracciano, L., Heim, M. H., & Libero, G. D. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.08.004 · Cited by 58 · see citing works

CD4-CD8-αβ and γδ T Cells Display Inflammatory and Regulatory Potentials during Human Tuberculosis

Pinheiro, M. D. B., Antonelli, L. R. D. V., Sathler-Avelar, R., Vitelli-Avelar, D. M., de Miranda, S. S., Guimarães, T. M. P. D., Teixeira‐Carvalho, A., Martins‐Filho, O. A., & Toledo, V. P. C. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050923 · Cited by 56 · see citing works

αβ Lineage‐committed thymocytes can be rescued by the γδ T cell receptor (TCR) in the absence of TCR β chain

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Shaping of T Cell Functions by Trogocytosis

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Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity

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Characterization of Defective CD4−CD8− T Cells in Murine Tumors Generated Independent of Antigen Specificity

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Double Negative (CD3+4−8−) TCRαβ Splenic Cells from Young NOD Mice Provide Long-Lasting Protection against Type 1 Diabetes

Duncan, B., Nazarov–Stoica, C., Surls, J., Kehl, M., Bona, C. A., Casares, S. A., & Brumeanu, T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011427 · Cited by 48 · see citing works

CRISPR screen identifies genes that sensitize AML cells to double-negative T-cell therapy

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Interleukin‐10 limits the expansion of immunoregulatory CD4−CD8− T cells in autoimmune‐prone non‐obese diabetic mice

Hillhouse, E. E., Beauchamp, C., Chabot‐Roy, G., Dugas, V., & Lesage, S. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.84 · Cited by 46 · see citing works

Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity

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Fas-Mediated Apoptosis Regulates the Composition of Peripheral αβ T Cell Repertoire by Constitutively Purging Out Double Negative T Cells

Mohamood, A. S., Bargatze, D., Xiao, Z., Jie, C., Yagita∥, H., Ruben, D. S., Watson, J., Chakravarti, S., Schneck, J. P., & Hamad, A. R. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003465 · Cited by 42 · see citing works

MHC Class II Restricted Innate-Like Double Negative T Cells Contribute to Optimal Primary and Secondary Immunity to Leishmania major

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Double-negative T resident memory cells of the lung react to influenza virus infection via CD11chi dendritic cells

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Expression Profiling of Murine Double-Negative Regulatory T Cells Suggest Mechanisms for Prolonged Cardiac Allograft Survival

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A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells

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Critical role of OX40 in the expansion and survival of CD4 T-cell-derived double-negative T cells

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Double-Negative T Cell Levels Correlate with Chronic Graft-versus-Host Disease Severity

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Phenotypic and functional evaluation of CD3+CD4-CD8- T cells in human CD8 immunodeficiency

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Identification of CD3+CD4−CD8− T Cells as Potential Regulatory Cells in an Experimental Murine Model of Graft-Versus-Host Skin Disease (GVHD)

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IL-7 Abrogates the Immunosuppressive Function of Human Double-Negative T Cells by Activating Akt/mTOR Signaling

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Analysis of gene profile, steady state proliferation and apoptosis of double-negative T cells in the periphery and gut epithelium provides new insights into the biological functions of the Fas pathway

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MHC-Independent Thymic Selection of CD4 and CD8 Coreceptor Negative αβ T Cells

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Safety and Efficacy of Ex Vivo Expanded Healthy Donor-Derived Double Negative T Cells for the Treatment of AML Relapsed after Allogeneic Stem Cell Transplantation: A First in-Human Phase I/IIa Clinical Trial

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Ox40 regulates the conversion and suppressive function of double-negative regulatory T cells

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NKG2D Enhances Double-Negative T Cell Regulation of B Cells

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CD4/CD8 Double-negative T-cell Lymphoma: A Variant of Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma?

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Autocrine IFNγ Controls the Regulatory Function of Lymphoproliferative Double Negative T Cells

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Untitled work

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An atlas of cells in the human tonsil

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Reproductive Ageing: Inflammation, immune cells, and cellular senescence in the aging ovary

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Long-term remission and survival in patients with relapsed or refractory multiple myeloma after treatment with LCAR-B38M CAR T cells: 5-year follow-up of the LEGEND-2 trial

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mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model

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Strategies for overcoming bottlenecks in allogeneic CAR-T cell therapy

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CAR+ T-Cell Lymphoma after Cilta-cel Therapy for Relapsed or Refractory Myeloma.

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Innate and Adaptive Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms

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Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

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The ups and downs of STAT3 function: too much, too little and human immune dysregulation

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Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis

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Advanced methods and novel biomarkers in autoimmune diseases ‑ a review of the recent years progress in systemic lupus erythematosus

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The association between immune cells and breast cancer: insights from Mendelian randomization and meta‐analysis

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Legend or Truth: Mature CD4+CD8+ Double-Positive T Cells in the Periphery in Health and Disease

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Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures

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Mapping the cellular landscape of Atlantic salmon head kidney by single cell and single nucleus transcriptomics

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Double Negative T Regulatory Cells: An Emerging Paradigm Shift in Reproductive Immune Tolerance?

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Double-Negative T (DNT) Cells in Patients with Systemic Lupus Erythematosus

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Quercetin counteracts monosodium glutamate to mitigate immunosuppression in the thymus and spleen via redox-guided cellular signaling

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Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

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Single-cell RNA sequencing shows the immune cell landscape in the kidneys of patients with idiopathic membranous nephropathy

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Yi-Fei-San-Jie Chinese medicine formula reverses immune escape by regulating deoxycholic acid metabolism to inhibit TGR5/STAT3/PD-L1 axis in lung cancer

Chen, Z., Rao, X., Sun, L., Qi, X., Wang, J., Wang, S., An, B., Lin, J., & Lin, L. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156175 · Cited by 23 · see citing works

Local type 2 immunity in eosinophilic gastritis

Morgenstern, N. B.-B., Shoda, T., Rochman, Y., Caldwell, J. M., Collins, M. H., Mukkada, V. A., Putnam, P. E., Bolton, S. M., Felton, J. M., Rochman, M., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.01.021 · Cited by 24 · see citing works

High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity

Núñez, N. G., Schmid, J., Power, L., Alberti, C., Krishnarajah, S., Kreutmair, S., Unger, S., Blanco, S., Konigheim, B. S., Marín, C., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01499-w · Cited by 20 · see citing works

Multiple Myeloma-Derived Extracellular Vesicles Modulate the Bone Marrow Immune Microenvironment

Lopes, R., Caetano, J., Barahona, F., Pestana, C., Ferreira, B. V., Lourenço, D., Queirós, A. C., Bilreiro, C., Shemesh, N., Beck, H. C., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.909880 · Cited by 23 · see citing works

Curcumin/L‐OHP co‐loaded HAP for cGAS‐STING pathway activation to enhance the natural immune response in colorectal cancer

Xiao, Y., Guo, G., Wang, H., Peng, B., Lin, Y., Qu, G., Li, B., Jiang, Z., Zhang, F., Wu, J., et al. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10610 · Cited by 20 · see citing works

The effect of ginsenoside Rg3 combined with chemotherapy on immune function in non-small cell lung cancer: A systematic review and meta-analysis of randomized controlled trials

Gao, S., Fang, C., Wang, T., Lu, W., Wang, N., Sun, L., Fang, W., Chen, Y., & Hu, R. (2023) · Medicine · doi:10.1097/md.0000000000033463 · Cited by 21 · see citing works

MultiGATE: integrative analysis and regulatory inference in spatial multi-omics data via graph representation learning

Miao, J., Li, J., Xin, J., Tu, J.-J., Ge, M., Qi, J., Zhou, X., Zhu, Y., Yang, C., & Lin, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-63418-x · Cited by 20 · see citing works

Adoptive Cell Therapy for T-Cell Malignancies

Fang, K., Lee, J. B., & Li, Z. (2022) · Cancers · doi:10.3390/cancers15010094 · Cited by 19 · see citing works

The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach

Khan, A. U., Khan, A., Shal, B., Khan, S., Khan, M., Ahmad, R., & Riaz, M. (2023) · Phytotherapy Research · doi:10.1002/ptr.7755 · Cited by 19 · see citing works

Heterogeneity of the Tumor Microenvironment Across Molecular Subtypes of Breast Cancer

Kashyap, D., Bal, A., Irinike, S., Khare, S., Bhattacharya, S., Das, A., & Singh, G. (2023) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000001139 · Cited by 19 · see citing works

Single-cell dissection of Merkel cell carcinoma heterogeneity unveils transcriptomic plasticity and therapeutic vulnerabilities

Das, B. K., Kannan, A., Velasco, G. J., Kunika, M. D., Lambrecht, N. W. G., Nguyen, Q., Zhao, H., Wu, J., & Gao, L. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101101 · Cited by 19 · see citing works

Thyroid Cancer—The Tumor Immune Microenvironment (TIME) over Time and Space

Jaume, J. C. (2025) · Cancers · doi:10.3390/cancers17050794 · Cited by 17 · see citing works

Systemic CD4 cytotoxic T cells improve protection against PRRSV-1 transplacental infection

Li, Y., Díaz, I., Martin-Valls, G. E., Beyersdorf, N., & Mateu, E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1020227 · Cited by 17 · see citing works

The significance of targeting lysosomes in cancer immunotherapy

Xu, Y., Shao, B., & Zhang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1308070 · Cited by 17 · see citing works

Decoding T cell senescence in cancer: Is revisiting required?

Magkouta, S., Markaki, E., Evangelou, K., Petty, R., Verginis, P., & Gorgoulis, V. G. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.11.003 · Cited by 17 · see citing works

The link between immunity and hypertension in the kidney and heart

Benson, L. N., Guo, Y., Deck, K. S., Mora, C. J., Liu, Y., & Mu, S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1129384 · Cited by 17 · see citing works

Potential alternatives to αβ-T cells to prevent graft-versus-host disease (GvHD) in allogeneic chimeric antigen receptor (CAR)-based cancer immunotherapy: A comprehensive review

Tang, C., & Zhang, Y. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155518 · Cited by 18 · see citing works

Sex-specific divergences in the types and timing of infiltrating immune cells during the intervertebral disc acute injury response and their associations with degeneration

Clayton, S. W., Walk, R. E., Mpofu, L., Easson, G. W. D., & Tang, S. Y. (2024) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2024.10.002 · Cited by 16 · see citing works

A Flow Cytometry-Based Examination of the Mouse White Blood Cell Differential in the Context of Age and Sex

Arlt, E., Kindermann, A., Fritsche, A., Santos, A. N., Kielstein, H., & Bazwinsky‐Wutschke, I. (2024) · Cells · doi:10.3390/cells13181583 · Cited by 15 · see citing works

HIF‐1α targeted deletion in myeloid cells decreases MDSC accumulation and alters microbiome in neonatal mice

Schwarz, J., Rühle, J., Stephan, K., Dietz, S., Geißert, J., Schoppmeier, U., Frick, J.-S., Hudalla, H., Lajqi, T., Poets, C. F., et al. (2023) · European Journal of Immunology · doi:10.1002/eji.202250144 · Cited by 15 · see citing works

Effects of Anti-CD20 Antibody Therapy on Immune Cell Dynamics in Relapsing-Remitting Multiple Sclerosis

Willison, A., Hagler, R., Weise, M., Elben, S., Huntemann, N., Masanneck, L., Pfeuffer, S., Lichtenberg, S., Golombeck, K. S., Preuth, L.-M., et al. (2025) · Cells · doi:10.3390/cells14070552 · Cited by 14 · see citing works

Age- and Sex-Matched Normal Leukocyte Subset Ranges in the General Population Defined with the EuroFlow Lymphocyte Screening Tube (LST) for Monoclonal B-Cell Lymphocytosis (MBL) vs. Non-MBL Subjects

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Renal tubular epithelial cells are constitutive non-cognate stimulators of resident T cells

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Randomized double-blind clinical study in patients with COVID-19 to evaluate the safety and efficacy of a phytomedicine (P2Et)

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Altered mitochondrial mass and low mitochondrial membrane potential of immune cells in patients with HBV infection and correlation with liver inflammation

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A chronic Pseudomonas aeruginosa mouse lung infection modeling the mucus obstruction, lung function, and inflammation of human cystic fibrosis

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Immuno-Contexture and Immune Checkpoint Molecule Expression in Mismatch Repair Proficient Colorectal Carcinoma

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Expression analysis of lymphocyte subsets and lymphocyte-to-monocyte ratio: reveling immunosuppression and chronic inflammation in breast cancer

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Characterization of double-negative T cells in colorectal cancers and their corresponding lymph nodes

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Spatial mapping of immune cell environments in NF2-related schwannomatosis vestibular schwannoma

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Prolonged administration of total glucosides of paeony improves intestinal immune imbalance and epithelial barrier damage in collagen-induced arthritis rats based on metabolomics-network pharmacology integrated analysis

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Circulating T cells: a promising biomarker of anti-PD-(L)1 therapy

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Targeting the lung tumour stroma: harnessing nanoparticles for effective therapeutic interventions

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Taraxacum mongolicum Hand.-Mazz. derived extracellular vesicles alleviate mastitis via NLRP3 inflammasome and NF-κB/MAPK pathways

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3D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System

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Chronic malaria exposure is associated with inhibitory markers on T cells that correlate with atypical memory and marginal zone-like B cells

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In Vitro Assessment of Thermo‐Responsive Scaffold as a 3D Synthetic Matrix for CAR‐T Potency Testing Against Glioblastoma Spheroids

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Interleukin 35-producing B cells prolong the survival of GVHD mice by secreting exosomes with membrane-bound IL-35 and upregulating PD-1/LAG-3 checkpoint proteins

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The Impact and Molecular Mechanisms of Exercise in Cancer Therapy

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Immune dysregulation in endometriosis: the T cell perspective

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Association between immune cells, inflammatory cytokines, and sarcopenia: Insights from a Mendelian randomization analysis

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Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET

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Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption

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BACH2-mediated CD28 and CD40LG axes contribute to pathogenesis and progression of T-cell lymphoblastic leukemia

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Diagnostic and prognostic value of double-negative T cells in colorectal cancer

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Circadian Oscillation of Leukocyte Subpopulations and Inflammatory Cytokines over a 24-H Period in Horses

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Tumor-infiltrated double-negative regulatory T cells predict outcome of T cell-based immunotherapy in nasopharyngeal carcinoma

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Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus on its management, challenged by chronic CMV infection

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Peripheral CD4+CD8+ double positive T cells: A potential marker to evaluate renal impairment susceptibility during systemic lupus erythematosus

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Double-negative T cells with a distinct transcriptomic profile are abundant in the peripheral blood of patients with breast cancer

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Immune cells display an abnormal maturation and a proinflammatory profile in telomere biology disorders

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High-dimensional phenotyping of the peripheral immune response in community-acquired pneumonia

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Double-negative T cells in combination with ursodeoxycholic acid ameliorates immune-mediated cholangitis in mice

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Evaluating the theranostic potential of ferumoxytol when combined with radiotherapy in a mammary dual tumor mouse model

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Co-targeting of VEGFR2 and PD-L1 promotes survival and vasculature normalization in pleural mesothelioma

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Synthesis, Characterization, and Comprehensive In Vitro and In Silico Evaluation of the Anti‐Inflammatory Potential of Novel 1,2,3‐Triazole–Arylidenehydrazide/Thiazolidinone Hybrids

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Elevated Th1 and terminally differentiated cytotoxic T cells with suppressed Tc17 lymphocytes in lung tissue of advanced COPD and IPF patients undergoing lung transplantation

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A pan-cancer single cell landscape reveals heterogeneity and functional diversity of double-negative T cells

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Interaction of immune cells with renal cancer development: Mendelian randomization (MR) study

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Inflammatory and immune variables as predictors of survival in dogs with myxomatous mitral valve disease

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DNA nanovaccines derived from ferritin-modified glycogens for targeted delivery to immature dendritic cells and for promotion of Th1 cell differentiation

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Evaluation of the clinical efficacy of mammotome minimally invasive rotary cutting surgery in the treatment of benign breast tumors: a comparative study

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The causal effect of inflammatory proteins and immune cell populations on diabetic nephropathy: evidence from Mendelian randomization

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Single-cell landscape dissecting the transcription and heterogeneity of innate lymphoid cells in ischemic heart

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Elevated TIM3 expression on bone marrow T cells drives immune dysfunction in early relapsed blood cancer after allogeneic hematopoietic stem cell transplantation

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Immunopathogenesis and Therapeutics of Systemic Lupus Erythematosus: an Integrative Review

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ATR Blockade Potentiates the Effects of Genotoxic Agents In Vitro and Promotes Antitumor Immunity in a Mouse Model of Non-Small Cell Lung Cancer

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Immune Phenotype and Postoperative Complications After Elective Surgery

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Cross-reactivity of T cell-specific antibodies in the bank vole (Myodes glareolus)

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Respiratory syncytial virus subtypes in children with bronchiolitis: does it correlate with clinical severity?

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Causal relationship between the gut microbiota, immune cells, and coronary heart disease: a mediated Mendelian randomization analysis

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Oncolytic cytomegaloviruses expressing EGFR-retargeted fusogenic glycoprotein complex and drug-controllable interleukin 12

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TYK2 : p.Pro1104Ala Variant Protects Against Autoimmunity by Modulating Immune Cell Levels

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CSTF2-impeded innate αβ T cell infiltration and activation exacerbate immune evasion of pancreatic cancer

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BCAP31 promotes colorectal cancer metastasis via oxidative phosphorylation-dependent macrophage immunosuppression: A single-cell transcriptomic study

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Effects of pegylated recombinant human granulocyte colony-stimulating factor on lymphocytes and white blood cells of patients with malignant tumor

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Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease

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Double‐negative T cells: Setting the stage for disease control or progression

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CD4-CD8-双阴性T细胞在B细胞介导免疫反应中的作用

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Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer

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Progress of DNT cells on immunotherapy

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