Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Karikó, Katalin, Buckstein, Michael, Ni, Houping, Weissman, Drew·2005·Immunity

DOI 10.1016/j.immuni.2005.06.008

Cited by (1,004)

Items 701–800 of 1,004

Mechanisms of immune system activation in mammalians by small interfering RNA (siRNA)
Behzad Mansoori, Ali Mohammadi, Solmaz Shirjang, Behzad Baradaran · 2015 · Artificial Cells Nanomedicine and Biotechnology
Impaired expression of indoleamine 2, 3‐dioxygenase in monocyte‐derived dendritic cells in response to Toll‐like receptor‐7/8 ligands
Gro Furset, Yngvar Fløisand, Mouldy Sioud · 2007 · Immunology
Immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics
Marina A. Dobrovolskaia, Scott E. McNeil · 2015 · Expert Opinion on Biological Therapy
Synthetic biology devices and circuits for RNA-based ‘smart vaccines’: a propositional review
Oliwia Andries, Tasuku Kitada, Katie Bodner, Niek N. Sanders, Ron Weiss · 2015 · Expert Review of Vaccines
Post-Transcriptional Regulation of Viral RNA through Epitranscriptional Modification
David Courtney · 2021 · Cells
The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer
Xinwei Xu, Jintu Huang, Dickson Kofi Wiredu Ocansey, Yuxuan Xia, Zihan Zhao, Zhiwei Xu, Yongmin Yan, Xu Zhang, Fei Mao · 2021 · Journal of Inflammation Research
Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA
Blakney, Anna K., McKay, Paul F., Christensen, Dennis, Yus, Bárbara Ibarzo, Aldon, Yoann, Follmann, Frank, Shattock, Robin J. · 2019 · Journal of Controlled Release
Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs
Zhong, Zifu, McCafferty, Séan, Opsomer, Lisa, Wang, Haixiu, Huysmans, Hanne, De Temmerman, Joyca, Lienenklaus, Stefan, Portela Catani, João Paulo, Combes, Francis, Sanders, Niek N. · 2021 · Molecular Therapy
Clinical characteristics and prognostic factors of myocarditis associated with the mRNA COVID‐19 vaccine
Wongi Woo, Ah Young Kim, Dong Keon Yon, Seung Won Lee, Jimin Hwang, Louis Jacob, Ai Koyanagi, Min S. Kim, Duk H. Moon, Jo W. Jung et al. · 2021 · Journal of Medical Virology
Regulation of antiviral innate immunity by chemical modification of viral RNA
Na Li, Tariq M. Rana · 2022 · Wiley Interdisciplinary Reviews - RNA
Aging-associated accumulation of mitochondrial DNA mutations in tumor origin
Minghua Kong, Lishu Guo, Weilin Xu, Chengpeng He, Xiaoyan Jia, Zhiyao Zhao, Zhenglong Gu · 2022 · Life Medicine
Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination
Aurélien Sokal, Paul Bastard, Pascal Chappert, Giovanna Barba Spaeth, Slim Fourati, Alexis Vandenberghe, Pauline Lagouge-Roussey, Isabelle Meyts, Adrian Gervais, Magali Bouvier‐Alias et al. · 2022 · The Journal of Experimental Medicine
The Dual Role of the Innate Immune System in the Effectiveness of mRNA Therapeutics
Albert Radikovich Muslimov, Valeriy Tereshchenko, Daniil Shevyrev, Anna S. Rogova, Kirill Viktorovich Lepik, Vasiliy V. Reshetnikov, Roman A. Ivanov · 2023 · International Journal of Molecular Sciences
Advances in the design and delivery of RNA vaccines for infectious diseases
Abhijeet Girish Lokras, Thomas Rønnemoes Bobak, Saahil Sandeep Baghel, Federica Sebastiani, Camilla Foged · 2024 · Advanced Drug Delivery Reviews
siRNA‐induced immunostimulation through TLR7 promotes antitumoral activity against HPV‐driven tumors in vivo
Norliana Khairuddin, Michael Paul Gantier, Stephen J. Blake, Sherry Y. Wu, Mark A. Behlke, Bryan R.G. Williams, Nigel A.J. McMillan · 2011 · Immunology and Cell Biology
Improving N6-methyladenosine site prediction with heuristic selection of nucleotide physical–chemical properties
Ming Zhang, Jia-Wei Sun, Zi Liu, Mingwu Ren, Hong‐Bin Shen, Dong‐Jun Yu · 2016 · Analytical Biochemistry
Gene/environment interactions in the pathogenesis of autoimmunity: New insights on the role of Toll-like receptors
Elena Gianchecchi, Alessandra Fierabracci · 2015 · Autoimmunity Reviews
A retrovirus packages nascent host noncoding RNAs from a novel surveillance pathway
Eckwahl, Matthew J., Sim, Soyeong, Smith, Derek, Telesnitsky, Alice, Wolin, Sandra L. · 2015 · Genes & Development
Immune Response and Molecular Mechanisms of Cardiovascular Adverse Effects of Spike Proteins from SARS-CoV-2 and mRNA Vaccines
Paolo Bellavite, Alessandra Ferraresi, Ciro Isidoro · 2023 · Biomedicines
Innate immune regulations and various siRNA modalities
Anju Kaushal · 2023 · Drug Delivery and Translational Research
Messenger RNA-Based Therapeutics and Vaccines: What’s beyond COVID-19?
Dongqiao Li, Cynthia Liu, Yingzhu Li, Rumiana Tenchov, Janet M. Sasso, Di Zhang, Dan Li, Lixue Zou, Xuezhao Wang, Qiongqiong Angela Zhou · 2023 · ACS Pharmacology & Translational Science
Computational design of mRNA vaccines
Yoo-Ah Kim, Kambiz Mousavi, A Khalili Yazdi, Magdalena Zwierzyna, Marco Cardinali, Dillion M. Fox, Thomas Peel, Jeff Coller, Kunal Aggarwal, Giulietta Maruggi · 2023 · Vaccine
mRNA-LNP COVID-19 Vaccine Lipids Induce Complement Activation and Production of Proinflammatory Cytokines: Mechanisms, Effects of Complement Inhibitors, and Relevance to Adverse Reactions
Tamás Bakos, Tamás Mészáros, Gergely Tibor Kozma, Petra Berényi, Réka Facskó, Henriette Farkas, László Dézsi, Carlo Heirman, Stefaan De Koker, Raymond Michel Schiffelers et al. · 2024 · International Journal of Molecular Sciences
The tRNA Val half: A strong endogenous Toll-like receptor 7 ligand with a 5′-terminal universal sequence signature
Kamlesh Pawar, Takuya Kawamura, Yohei Kirino · 2024 · Proceedings of the National Academy of Sciences
Multi-level regulation of cellular recognition of viral dsRNA
Alys Peisley, Sun Hur · 2012 · Cellular and Molecular Life Sciences
Hepatitis C Virus Is a Weak Inducer of Interferon Alpha in Plasmacytoid Dendritic Cells in Comparison with Influenza and Human Herpesvirus Type-1
Françoise Gondois‐Rey, Clélia Dental, Philippe Halfon, Thomas F. Baumert, Daniel Olive, Ivan Hirsch · 2009 · PLoS ONE
Improved RNA modification mapping of cellular non-coding RNAs using C- and U-specific RNases
Priti Thakur, Mariana Estevez, Peter A. Lobue, Patrick A. Limbach, Balasubrahmanyam Addepalli · 2019 · The Analyst
Transcription, mRNA Export, and Immune Evasion Shape the Codon Usage of Viruses
Christine Mordstein, Laura Cano, Atahualpa Castillo-Morales, Bethan Young, Alexander T Ho, Alan M. Rice, Michael Andre Liss, Laurence D. Hurst, Grzegorz R. Kudla · 2021 · Genome Biology and Evolution
Emerging immunomodulatory strategies for cell therapeutics
Corrine Ying Xuan Chua, Allen Yujie Jiang, Tatiane Eufrásio-da-Silva, Alireza Dolatshahi‐Pirouz, Róbert Langer, Gorka Orive, Alessandro Grattoni · 2022 · Trends in biotechnology
Polyplex designs for improving the stability and safety of RNA therapeutics
Satoshi Uchida, Chun Yin Jerry Lau, Makoto Oba, Kanjiro Miyata · 2023 · Advanced Drug Delivery Reviews
Epigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses
Shuang Ding, Haibin Liu, Lijuan Liu, Li Ma, Zhen Chen, Miao Zhu, Lishi Liu, Xueyan Zhang, Haojie Hao, Li Zuo et al. · 2024 · Cell Death and Disease
Microfluidic Platform Enables Shearless Aerosolization of Lipid Nanoparticles for mRNA Inhalation
Jeonghwan Kim, Antony Jozić, Elissa Bloom, Brian Jones, Michael Marra, Namratha Turuvekere Vittala Murthy, Yulia Eygeris, Gaurav Sahay · 2024 · ACS Nano
Exogenous RNA surveillance by proton-sensing TRIM25
Myeonghwan Kim, Youngjoon Pyo, Seong‐In Hyun, Minseok Jeong, Yeon Choi, V. Narry Kim · 2025 · Science
Nebulisation of IVT mRNA Complexes for Intrapulmonary Administration
Sarah M. Johler, Joanna Rejman, Shan Guan, Joseph Rosenecker · 2015 · PLoS ONE
Literature review of baseline information on non‐coding RNA (ncRNA) to support the risk assessment of ncRNA‐based genetically modified plants for food and feed
Alberto Dávalos, Rossana Henriques, María Jesús Latasa, Moisés Laparra, Marı́a A. Coca · 2019 · EFSA Supporting Publications
Programmable RNA base editing via targeted modifications
Jinghui Song, Yuan Zhuang, Chengqi Yi · 2024 · Nature Chemical Biology
Characterisation and analysis of mRNA critical quality attributes using liquid chromatography based methods
Alexandra L.J. Webb, Emma N. Welbourne, Caroline A. Evans, Mark J. Dickman · 2025 · Journal of Chromatography A
Lipid nanoparticle (LNP) mediated mRNA delivery in neurodegenerative diseases
Seyedeh Ghazal Moosavi, Niloufar Rahiman, Mahmoud Reza Jaafari, Leila Arabi · 2025 · Journal of Controlled Release
Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis
Camille Guillerey, Melvyn T. Chow, Kim M. Miles, Stuart D. Olver, Jaclyn Sceneay, Kazuyoshi Takeda, Andreas Möller, Mark John Smyth · 2015 · OncoImmunology
Synthetic mRNAs for manipulating cellular phenotypes: an overview
Elgar Susanne Quabius, Guido Krupp · 2014 · New Biotechnology
Bacterial RNAs activate innate immunity in Arabidopsis
Bo‐Young Lee, Yongsoon Park, Soohyun Lee, Geun Cheol Song, Choong‐Min Ryu · 2015 · New Phytologist
Promises and Challenges in Developing RNAi as a Research Tool and Therapy
Mouldy Sioud · 2010 · Methods in molecular biology
Nucleic Acid Polymers Are Active against Hepatitis Delta Virus InfectionIn Vitro
Frauke Beilstein, Matthieu Blanchet, Andrew Vaillant, Camille Sureau · 2017 · Journal of Virology
A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature
Changhoon Oh, Jeongmin Ryoo, Kiwon Park, Baek Kim, Michele B. Daly, Dong-Yeon Cho, Kwangseog Ahn · 2018 · Scientific Reports
mRNA Vaccines against Flaviviruses
Wollner, Clayton J., Richner, Justin M. · 2021 · Vaccines
Profiles of current COVID-19 vaccines
Franz Xaver Heinz, Karin Stiasny · 2021 · Wiener klinische Wochenschrift
Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins
Anissa Guillemin, Anuj Kumar, Mélanie Wencker, Emiliano P. Ricci · 2022 · Frontiers in Immunology
Atelocollagen-mediated Systemic Delivery Prevents Immunostimulatory Adverse Effects of siRNA in Mammals
Shinichiro Inaba, Shunji Nagahara, Naoki Makita, Yuzo Tarumi, Takuji Ishimoto, Seiichi Matsuo, Kenji Kadomatsu, Yoshifumi Takei · 2011 · Molecular Therapy
Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors
Soroush T. Sarvestani, H. James Stunden, Mark A. Behlke, Samuel C. Forster, Claire E. McCoy, Michelle D. Tate, Jonathan Ferrand, Kim A. Lennox, Eicke Latz, Bryan R.G. Williams et al. · 2014 · Nucleic Acids Research
Innate immunity networks during infection withBorrelia burgdorferi
Marije Oosting, Kathrin Buffen, Jos W. M. van der Meer, Mihai Gheorghe Netea, Leo A. B. Joosten · 2014 · Critical Reviews in Microbiology
2-Thiouracil deprived of thiocarbonyl function preferentially base pairs with guanine rather than adenine in RNA and DNA duplexes
Elżbieta Sochacka, Roman H. Szczepanowski, Marek Cypryk, Milena Sobczak, Magdalena Janicka, Karina Kraszewska, Paulina Bartos, Anna Chwialkowska, Barbara Nawrot · 2015 · Nucleic Acids Research
LncRNAs in the Type I Interferon Antiviral Response
Beatriz Suárez, Laura Prats-Mari, Juan Pablo Unfried, Puri Fortes · 2020 · International Journal of Molecular Sciences
Immunogenicity mechanism of mRNA vaccines and their limitations in promoting adaptive protection against SARS-CoV-2
Mohd Zulkifli Salleh, Mohd Nor Norazmi, Zakuan Zainy Deris · 2022 · PeerJ
Reprogramming of Urine-Derived Renal Epithelial Cells into iPSCs Using srRNA and Consecutive Differentiation into Beating Cardiomyocytes
Heidrun Steinle, Marbod Weber, Andreas Behring, Ulrike Angelika Mau-Holzmann, Christiane VON OHLE, Aron‐Frederik Popov, Christian Schlensak, Hans Peter Wendel, Meltem Avci‐Adali · 2019 · Molecular Therapy — Nucleic Acids
Chemically Modified mocRNAs for Highly Efficient Protein Expression in Mammalian Cells
Abhishek J. Aditham, Hailing Shi, Jianting Guo, Hu Zeng, Yiming Zhou, Sarah D. Wade, Jiahao Huang, Jia Liu B, Xiao Wang · 2022 · ACS Chemical Biology
RNA Therapeutics: the Next Generation of Drugs for Cardiovascular Diseases
Nada Bejar, Trinh To Tat, Dániel Kiss · 2022 · Current Atherosclerosis Reports
Engineered mRNA Delivery Systems for Biomedical Applications
Ji Wang, Haofang Zhu, Jingjing Gan, Gaofeng Liang, Ling Li, Yuanjin Zhao · 2023 · Advanced Materials
Lipid Nanoparticle-Based Delivery SystemA Competing Place for mRNA Vaccines
Xinyu Zhang, Yuanfang Li, Zehua Zhou · 2024 · ACS Omega
Electrochemical Glycosylation via Halogen-Atom-Transfer for C -Glycoside Assembly
Jun Wu, Purushothaman Rajeshwaran, Felix Kallert, Simon L. Homölle, Lutz Ackermann · 2024 · ACS Catalysis
Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70
Byron Brook, Valerie Duval, Soumik Barman, Lauren Speciner, Cali Sweitzer, Asad Khanmohammed, Manisha Menon, Kimberly Foster, Pallab Ghosh, Kimia Abedi et al. · 2024 · Science Translational Medicine
Direct RNA sequencing enables improved transcriptome assessment and tracking of RNA modifications for medical applications
Charlotte Hewel, Anna Wierczeiko, Johannes Miedema, Johannes H. Friedrich, Felix Hofmann, Stephan Weißbach, Vincent Dietrich, Laura Holthöfer, Verena Haug, Stefan Mündnich et al. · 2025 · Nucleic Acids Research
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses
Diana Castaño, Emily Bettini, Binod Kumar, Aleksey Chudnovskiy, Anna Siv, Giulia Protti, Sandra Nakandakari-Higa, Simona Ceglia, Nina De Luna, Joy E. Chiu et al. · 2025 · Cell
Staying on message: design principles for controlling nonspecific responses to siRNA
Shirley Samuel‐Abraham, Joshua N. Leonard · 2010 · FEBS Journal
Probing RNA Modification Status at Single-Nucleotide Resolution in Total RNA
Nian Liu, Tao Pan · 2015 · Methods in enzymology on CD-ROM/Methods in enzymology
Monitoring Translation Activity of mRNA-Loaded Nanoparticles in Mice
Sebastian Rosigkeit, Martin Meng, Christian R. Grunwitz, Patrícia Gomes, Andreas Kreft, Nina Hayduk, Rosario Heck, Geethanjali Pickert, Kira Ziegler, Yasmin Abassi et al. · 2018 · Molecular Pharmaceutics
MicroRNAs and their delivery in diabetic fibrosis
Alexa Wonnacott, Laura Denby, Richard J. Coward, Donald J. Fraser, Timothy Bowen · 2021 · Advanced Drug Delivery Reviews
Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment
Md. Emranul Karim, Sheikh Tanzina Haque, Hamed Al-Busaidi, Athirah Bakhtiar, Kyi Kyi Tha, Mark M. Banaszak Holl, Ezharul Hoque Chowdhury · 2022 · Archives of Pharmacal Research
Feeder‐Free Reprogramming of Human Fibroblasts with Messenger RNA
Luigi A. Warren, Jiwu Wang · 2013 · Current Protocols in Stem Cell Biology
Stronger together for in-cell translation: natural and unnatural base modified mRNA
Lisa Bornewasser, Christof Domnick, Stephanie Kath‐Schorr · 2022 · Chemical Science
Nanoscale delivery platforms for RNA therapeutics: Challenges and the current state of the art
Luke H. Rhym, Daniel G. Anderson · 2022 · Med
N1-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs
Tien-Hao Chen, Vladimir Potapov, Nan Dai, Jennifer L. Ong, Bijoyita Roy · 2022 · Scientific Reports
Bioinspired Lipid Nanocarriers for RNA Delivery
Alex Golubovic, Shannon Tsai, Bowen Li · 2023 · ACS Bio & Med Chem Au
Toxicological Assessments of a Pandemic COVID-19 Vaccine—Demonstrating the Suitability of a Platform Approach for mRNA Vaccines
Cynthia M. Rohde, Claudia Lindemann, Michael A. Giovanelli, Rani S. Sellers, Jan Diekmann, Shambhunath Choudhary, Lila Ramaiah, Annette B. Vogel, Yana Chervona, Alexander Muik et al. · 2023 · Vaccines
The emerging potential of siRNA nanotherapeutics in treatment of arthritis
Anjali Kumari, Amanpreet Kaur, Geeta Aggarwal · 2023 · Asian Journal of Pharmaceutical Sciences
Therapeutic synthetic and natural materials for immunoengineering
Anna Slezak, Kevin Chang, Samir Hossainy, Aslan Mansurov, Stuart J. Rowan, Jeffrey A. Hubbell, Mustafa Ozgur Guler · 2024 · Chemical Society Reviews
Advances in Poultry Vaccines: Leveraging Biotechnology for Improving Vaccine Development, Stability, and Delivery
Khaled Abdelaziz, Yosra A. Helmy, Alexander Yitbarek, Douglas C. Hodgins, Tamer A. Sharafeldin, Mohamed H. Selim · 2024 · Vaccines
Current Analytical Strategies for mRNA-Based Therapeutics
Julien Camperi, Kamalakar Chatla, Emily C. Freund, Carolina Galan, Steffen Lippold, Axel Guilbaud · 2025 · Molecules
Nucleic Acid Polymers with Accelerated Plasma and Tissue Clearance for Chronic Hepatitis B Therapy
Ingo Roehl, Stephan Seiffert, Celia Brikh, Jonathan Quinet, Catherine Jamard, Nadine Dorfler, Jennifer A. Lockridge, Lucyna Cova, Andrew Vaillant · 2017 · Molecular Therapy — Nucleic Acids
Polymers Strive for Accuracy: From Sequence-Defined Polymers to mRNA Vaccines against COVID-19 and Polymers in Nucleic Acid Therapeutics
Aman Ishaqat, Andreas Herrmann · 2021 · Journal of the American Chemical Society
Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus
Miaoge Xue, Yuexiu Zhang, Haitao Wang, Elizabeth L. Kairis, Mijia Lu, Sadeem Ahmad, Zayed Attia, Olivia E. Harder, Zijie Scott Zhang, Jiangbo Wei et al. · 2021 · PLoS Pathogens
Current strategies employed in the manipulation of gene expression for clinical purposes
Hsing‐Chuan Tsai, Violena Pietrobon, Maoyu Peng, Suning Wang, Lihong Zhao, Francesco Maria Marincola, Qi Cai · 2022 · Journal of Translational Medicine
Modulating the expression of tumor suppressor genes using activating oligonucleotide technologies as a therapeutic approach in cancer
Georgina L. Gregory, Ian M. Copple · 2022 · Molecular Therapy — Nucleic Acids
Mechanisms and research advances in mRNA antibody drug-mediated passive immunotherapy
Yuxiang Zhao, Linchuan Gan, Dangjin Ke, Qi Chen, Yajuan Fu · 2023 · Journal of Translational Medicine
A Novel Self‐Amplifying mRNA with Decreased Cytotoxicity and Enhanced Protein Expression by Macrodomain Mutations
Yue Gong, Danni Yong, Gensheng Liu, Jiang Xu, Jun Ding, William W.-G. Jia · 2024 · Advanced Science
Heart Regeneration: Opportunities and Challenges for Drug Discovery with Novel Chemical and Therapeutic Methods or Agents
Alleyn T. Plowright, Ola Engkvist, Adrian L. Gill, Laurent Knerr, Qing‐Dong Wang · 2014 · Angewandte Chemie International Edition
Therapeutic Delivery of mRNA: The Medium Is the Message
R. Scott McIvor · 2011 · Molecular Therapy
Novel ribonuclease activity of cusativin from Cucumis sativus for mapping nucleoside modifications in RNA
Balasubrahmanyam Addepalli, Sarah Venus, Priti Thakur, Patrick A. Limbach · 2017 · Analytical and Bioanalytical Chemistry
RNA regulatory processes in RNA virus biology
Shaun T. Cross, Daniel Michalski, Megan R. Miller, Jeffrey Wilusz · 2019 · Wiley Interdisciplinary Reviews - RNA
Optimizing Modified mRNA In Vitro Synthesis Protocol for Heart Gene Therapy
Yoav Hadas, Nishat Sultana, Elias Youssef, Mohammad Tofael Kabir Sharkar, Keerat Kaur, Elena Chepurko, Lior Zangi · 2019 · Molecular Therapy — Methods & Clinical Development
RNA N6-methyladenosine: a promising molecular target in metabolic diseases
Yan Li, Jiawen Wang, Chunyan Huang, Meng Shen, Huakui Zhan, Keyang Xu · 2020 · Cell & Bioscience
Pseudouridines in RNAs: switching atoms means shifting paradigms
Ting‐Yu Lin, Rahul Mehta, Sebastian Glatt · 2021 · FEBS Letters
Delivery of synthetic mRNAs for tissue regeneration
Heidrun Steinle, Marbod Weber, Sandra Stoppelkamp, Katharina Große‐Berkenbusch, Sonia Golombek, Marbod Weber, Tuba Çanak-Ipek, Sarah-Maria Trenz, Christian Schlensak, Meltem Avci‐Adali · 2021 · Advanced Drug Delivery Reviews
TLR Ignores Methylated RNA?
Ken J. Ishii, Shizuo Akira · 2005 · Immunity
An mRNA vaccine elicits STING-dependent antitumor immune responses
Zhe Chen, Chaoyang Meng, Junhua Mai, Yongbin Liu, Hangwen Li, Haifa Shen · 2022 · Acta Pharmaceutica Sinica B
Vaccination-Associated Myocarditis and Myocardial Injury
Natasha Lipson Altman, Amber A. Berning, Sarah Mann, Robert A. Quaife, Edward Allen Gill, Scott R. Auerbach, Thomas Campbell, Michael R. Bristow · 2023 · Circulation Research
Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors
Xiaobing He, Huaijie Jia, Zhizhong Jing, Ding Xiang Liu · 2013 · Acta Biochimica et Biophysica Sinica
Host RNA Packaging by Retroviruses: A Newly Synthesized Story
Matthew J. Eckwahl, Alice Telesnitsky, Sandra L. Wolin · 2016 · mBio
Neue Modalitäten für schwierige Zielstrukturen in der Wirkstoffentwicklung
Eric Valeur, Stéphanie M. Guéret, Hélène Adihou, Ranganath Gopalakrishnan, Malin Lemurell, Herbert Waldmann, Tom N. Grossmann, Alleyn T. Plowright · 2017 · Angewandte Chemie
Nucleotide Modifications Decrease Innate Immune Response Induced by Synthetic Analogs of snRNAs and snoRNAs
Grigory A. Stepanov, Evgenii S. Zhuravlev, Victoria О. Shender, Anna A. Nushtaeva, Evgenia Balakhonova, Elena Mozhaeva, Marat F. Kasakin, Vladimir V. Koval, Alexander A. Lomzov, Marat S. Pavlyukov et al. · 2018 · Genes
2′-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms
Isabel Freund, Daniel K. Buhl, Sébastien Boutin, Annika Kötter, Florian Pichot, Virginie Marchand, Tim Vierbuchen, Holger Heine, Yuri Motorin, Mark Helm et al. · 2019 · RNA