The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Macrophage Polarization Comes of Age
Open accessAbstract
Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity]).
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In the citing paper
“In contrast, M2 macrophages are involved in polarized Th2 inflammatory reactions and characterized by expression of arginase-1 and mannose and scavenger receptors [19], [20].”
From Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo (2014) · cites this paper as [19]
In the citing paper
“M1 macrophages are IL-12high, IL-23high, IL-10low; produce high levels of inducible nitric oxide synthetase (iNOS); secrete inflammatory cytokines such as IL-1β, IL-6, and TNF; and are inducer and effector cells in Th1 type inflammatory responses [19].”
From Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo (2014) · cites this paper as [19]
Citations
Cites
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Self-citationAlternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765
Flagged first, then by citations
Research works printed but not linked: 10
- Dinarello, 2005, Blocking IL-1 in systemic inflammation, J. Exp. Med., 201, 1355, 10.1084/jem.20050640 · DOI
- Duffield, 2005, Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair, J. Clin. Invest., 115, 56, 10.1172/JCI200522675 · DOI · Paper page
- Fang, 2004, Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP, J. Immunol., 173, 360, 10.4049/jimmunol.173.1.360 · DOI
- Herbert, 2004, Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology, Immunity, 20, 623, 10.1016/S1074-7613(04)00107-4 · DOI
- Mantovani, 2002, Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes, Trends Immunol., 23, 549, 10.1016/S1471-4906(02)02302-5 · DOI · Paper page
- Noel, 2004, Alternatively activated macrophages during parasite infections, Trends Parasitol., 20, 126, 10.1016/j.pt.2004.01.004 · DOI
- Pull, 2005, Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury, Proc. Natl. Acad. Sci. USA, 102, 99, 10.1073/pnas.0405979102 · DOI
- Rauh, 2005, SHIP represses the generation of alternatively activated macrophages, Immunity, 24, 361, 10.1016/j.immuni.2005.09.003 · DOI
- Scotton, 2005, Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13, J. Immunol., 174, 834, 10.4049/jimmunol.174.2.834 · DOI
- Zhu, 2004, Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation, Science, 304, 1678, 10.1126/science.1095336 · DOI
Cited by
Sorted by citations
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Self-citationThe Immune Landscape of Cancer
Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T.-H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.023 · Cited by 5,870
“IL-13 influences macrophage polarization (Mantovani et al., 2005), implying a possible basis for our observation that IL-13 deletions associated with altered M0 macrophage fractions.”
BackgroundAlternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197
“Macrophages are a prominent component of the stroma and leukocyte infiltrate in human and experimental mouse tumors (DeNardo et al., 2009; Gocheva et al., 2010; Grivennikov et al., 2010; Hallam et al., 2009; Joyce and Pollard, 2009; Mantovani et al., 2008; Sinha et al., 2007).”
BackgroundMacrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160
“These preferential production of IL-12 or IL-10 set the basis for the M1/M2 polarization paradigm (3, 4, 9, 10), elsewhere defined as elicitation of functionally distinct”
BackgroundInfluentialSelf-citationAlternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Metadata
- Authors
- Mantovani, Sica, & Locati, M.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Mantovani,, Alberto
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 23
- Issue
- 4
- Pages
- 344-346
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1986736465
- Cited by
- 1,259
- References
- 0
- Citations by year
- 2026: 41 · 2025: 60 · 2024: 58 · 2023: 54 · 2022: 70 · 2021: 65 · 2020: 68 · 2019: 58 · 2018: 57 · 2017: 70 · 2016: 67 · 2015: 64 · 2014: 85 · 2013: 89 · 2012: 80
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2846 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Associazione Italiana per la Ricerca sul Cancro
- European Commission
- Ministero della Salute
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- macrophage polarization, M1 macrophages, M2 macrophages, mononuclear phagocytes, macrophage plasticity
- MeSH terms
- Cell Differentiation, Macrophages
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