Cited by 3,605T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisTGF-β signaling in diseases

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TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

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Veldhoen, Marc, Hocking, Richard J., Atkins, Christopher J., Locksley, Richard M., Stockinger, Brigitta·2006·Immunity

DOI 10.1016/j.immuni.2006.01.001

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Abstract

We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the presence of TLR3, TLR4, or TLR9 stimuli. Treg can be substituted by TGFbeta1, which, together with the proinflammatory cytokine IL-6, supports the differentiation of IL-17-producing T cells, a process that is amplified by IL-1beta and TNFalpha. We could not detect a role for IL-23 in the differentiation of IL-17-producing T cells but confirmed its importance for their survival and expansion. Transcription factors GATA-3 and T-bet, as well as its target Hlx, are absent in IL-17-producing T cells, and they do not express the negative regulator for TGFbeta signaling, Smad7. Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells.

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Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
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Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906
Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12
Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K. P., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00070-4 · Cited by 2,819
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
Thornton, A. M., & Shevach, E. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.287 · Cited by 2,637
The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384
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Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J., Farr, A. G., & Rudensky, A. Y. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.016 · Cited by 2,302
Toll Pathway-Dependent Blockade of CD4 + CD25 + T Cell-Mediated Suppression by Dendritic Cells
Pasare, C., & Medzhitov, R. M. (2003) · Science · doi:10.1126/science.1078231 · Cited by 2,000
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
REGULATION OF IMMUNE RESPONSES BY TGF-β
Letterio, J. J., & Roberts, A. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.137 · Cited by 1,894
Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17
Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
Nakao, A., Afrakhte, M., Morn, A., Nakayama, T., Christian, J. L., Heuchel, R. L., Itoh, S., Kawabata, M., Heldin, N., Heldin, C., et al. (1997) · Nature · doi:10.1038/39369 · Cited by 1,796
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669
Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β
Nakamura, K., Kitani, A., & Strober, W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.629 · Cited by 1,596
gp 130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES
Taga, T., & Kishimoto, T. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.797 · Cited by 1,468
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling
Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Wrana, J. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80303-7 · Cited by 1,322
Regulatory T cells in the control of immune pathology
Maloy, K. J., & Powrie, F. M. (2001) · Nature Immunology · doi:10.1038/ni0901-816 · Cited by 1,177
Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses
Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,053
Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells
Szabo, S. J., Dighe, A. S., Gubler, U., & MURPHY, K. M. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.817 · Cited by 982
Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease
Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
Fontenot, J. D., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1179 · Cited by 957
Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
Ulloa, L., Doody, J. F., & Massagué, J. (1999) · Nature · doi:10.1038/17826 · Cited by 812
Transforming growth factor-β in T-cell biology
Gorelik, L., & Flavell, R. A. (2002) · Nature Reviews Immunology · doi:10.1038/nri704 · Cited by 792
Interleukin‐2 is essential for CD4+CD25+ regulatory T cell function
Rosa, M. D. L., Rutz, S., Dorninger, H., & Scheffold, A. (2004) · European Journal of Immunology · doi:10.1002/eji.200425274 · Cited by 624
Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
Stetson, D. B., Mohrs, M., Reinhardt, R. L., Baron, J. L., Wang, Z., Gapin, L., Kronenberg, M., & Locksley, R. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030630 · Cited by 618
Interleukin 6 is required for the development of collagen-induced arthritis
Alonzi, T., Fattori, E., Lazzaro, D., Costa, P., Probert, L., Kollias, G., De Benedetti, F., Poli, V., & Ciliberto, G. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.461 · Cited by 604
TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
Belghith, M., Bluestone, J. A., Barriot, S., Megret, J., Bach, J., & Chatenoud, L. (2003) · Nature Medicine · doi:10.1038/nm924 · Cited by 591
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Piccirillo, C. A., Letterio, J. J., Thornton, A. M., McHugh, R. S., Mamura, M., Mizuhara, H., & Shevach, E. M. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020590 · Cited by 589
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Chen, Y., Thai, P., Zhao, Y.-H., Ho, Y.-S., DeSouza, M. M., & Wu, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210429200 · Cited by 577
Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis
Bettelli, E., Sullivan, B., Szabo, S. J., Sobel, R., Glimcher, L., & Kuchroo, V. (2004) · Journal of Experimental Medicine · doi:10.1084/jem.20031819 · Cited by 546
Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation
Gorelik, L., Constant, S. L., & Flavell, R. A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012076 · Cited by 544
IL-10–producing and naturally occurring CD4+ Tregs: limiting collateral damage
O’Garra, A., Vieira, P. L., Vieira, P., & Goldfeld, A. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci23215 · Cited by 530
T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells
Fahlén, L., Read, S., Gorelik, L., Hurst, S. D., Coffman, R. L., Flavell, R. A., & Powrie, F. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040685 · Cited by 516
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
Ogawa, A., Andoh, A., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Clinical Immunology · doi:10.1016/j.clim.2003.09.013 · Cited by 495
Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells
Kaisho, T., Takeuchi, O., Kawai, T., Hoshino, K., & Akira, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5688 · Cited by 489
Transforming growth factor beta: the good, the bad, and the ugly.
Wahl, S. M. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1587 · Cited by 486
Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers
Almeida, A. R. M., Legrand, N., Papiernik, M., & Freitas, A. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4850 · Cited by 468
Claudins regulate the intestinal barrier in response to immune mediators
Kinugasa, T., Sakaguchi, T., Gu, X., & Reinecker, H. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70351-9 · Cited by 463
Interleukin 6 plays a key role in the development of antigen-induced arthritis
Ohshima, S., Saeki, Y., Mima, T., Sasai, M., Nishioka, K., Nomura, S., Kopf, M., Katada, Y., Tanaka, T., Suemura, M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8222 · Cited by 406
Cutting Edge: TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression
Gorelik, L., Fields, P. E., & Flavell, R. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4773 · Cited by 391
T cells in inflammatory bowel disease: protective and pathogenic roles
Powrie, F. M. (1995) · Immunity · doi:10.1016/1074-7613(95)90086-1 · Cited by 351
Toll-like receptors and dendritic cells: for whom the bug tolls
Sousa, C. R. E. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2003.10.004 · Cited by 341
Differential Regulation of Murine T Lymphocyte Subsets
Fitch, F. W., McKisic, M. D., Lancki, D. W., & Gajewski, T. F. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.000333 · Cited by 338
Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction
Mullen, A. C., Hutchins, A. S., High, F. A., Lee, H. W., Sykes, K. J., Chodosh, L. A., & Reiner, S. L. (2002) · Nature Immunology · doi:10.1038/ni807 · Cited by 308
Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell–mediated spontaneous autoimmune arthritis in mice
Hata, H., Sakaguchi, N., Yoshitomi, H., Iwakura, Y., Sekikawa, K., Azuma, Y., Kanai, C., Moriizumi, E., Nomura, T., Nakamura, T., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21795 · Cited by 304
Rapid onset synovial inflammation and hyperplasia induced by transforming growth factor beta.
Allen, J. B., Manthey, C. L., Hand, A. R., Ohura, K., Ellingsworth, L. R., & Wahl, S. M. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.1.231 · Cited by 255
IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein.
Okuda, Y., Sakoda, S., Bernard, C. C. A., Fujimura, H., Saeki, Y., Kishimoto, T., & Yanagihara, T. (1998) · International Immunology · doi:10.1093/intimm/10.5.703 · Cited by 244
Interleukin-17
Fossiez, F., Banchereau, J., Murray, R. M., van Kooten, C., Garrone, P., & Lebecque, S. (1998) · International Reviews of Immunology · doi:10.3109/08830189809043008 · Cited by 212
CD25+CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production
Barthlott, T. (2005) · International Immunology · doi:10.1093/intimm/dxh207 · Cited by 209
Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia.
Fava, R. A., Olsen, N. J., Postlethwaite, A. E., Broadley, K. N., Davidson, J. M., Nanney, L. B., Lucas, C., & Townes, A. S. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.5.1121 · Cited by 198
Silencing T-bet Defines a Critical Role in the Differentiation of Autoreactive T Lymphocytes
Lovett‐Racke, A. E., Rocchini, A., Choy, J., Northrop, S. C., Hussain, R. Z., Ratts, R. B., Sikder, D. S., & Racke, M. K. (2004) · Immunity · doi:10.1016/j.immuni.2004.09.010 · Cited by 183
TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression
Heath, V. L., Murphy, E. E., Crain, C., Tomlinson, M. G., & O’Garra, A. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200009)30:9 · Cited by 172
TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet
Lin, J. T., Martin, S. L., Xia, L., & Gorham, J. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.5950 · Cited by 170
Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+ Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation
Chen, C.-H., Seguin‐Devaux, C., Burke, N. A., Oriss, T. B., Watkins, S. C., Clipstone, N. A., & Ray, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021170 · Cited by 166
Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta.
Wahl, S. M., Allen, J. B., Costa, G. L., Wong, H. L., & Dasch, J. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.1.225 · Cited by 155
IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human
Vanden Eijnden, S., Goriely, S., De Wit, D., Willems, F., & Goldman, M. (2005) · European Journal of Immunology · doi:10.1002/eji.200425677 · Cited by 148
Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment
Annacker, O., Burlen‐Defranoux, O., Pimenta‐Araujo, R., Cumano, A., & Bandeira, A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.7.3573 · Cited by 146
IL-6 Increases Primed Cell Expansion and Survival
Rochman, I., Paul, W., & Ben-Sasson, S. (2005) · Journal of Immunology · doi:10.4049/jimmunol.174.8.4761 · Cited by 138
TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia
Letterio, J. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208922 · Cited by 78
The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells
Lugo‐Villarino, G., Ito, S.-I., Klinman, D. M., & Glimcher, L. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506638102 · Cited by 60
Functional recognition of in vivo processed self antigen
Stocklnger, B., & Hafsmann, B. (1994) · International Immunology · doi:10.1093/intimm/6.2.247 · Cited by 51
TGF-β1 differentially regulates IL-2 expression and [3H]-thymidine incorporation in CD3ε mAb- and CD28 mAb-activated splenocytes and thymocytes
McKarns, S. C., & Kaminski, N. E. (2000) · Immunopharmacology · doi:10.1016/s0162-3109(00)00183-1 · Cited by 22
The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2
Eugster (1998) · Pure Amsterdam UMC · doi:10.1002/(sici)1521-4141(199807)28:07 · Cited by 2

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Authors: Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B.
Affiliations: National Institute for Medical Research (GB)
Howard Hughes Medical Institute (US)
Corresponding author: Stockinger, Brigitta
ORCID: Veldhoen, Marc
Locksley, Richard M.
Stockinger, Brigitta
Venue: Immunity
Publisher: Elsevier BV
Published: 2006-02
Volume: 24
Issue: 2
Pages: 179-189
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2006.01.001
OpenAlex: W2112866067
Cited by: 3,605
References: 70
Citations by year: 2026: 41 · 2025: 54 · 2024: 71 · 2023: 91 · 2022: 110 · 2021: 149 · 2020: 113 · 2019: 114 · 2018: 122 · 2017: 158 · 2016: 138 · 2015: 172 · 2014: 182 · 2013: 219 · 2012: 246
FWCI: 126.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2759 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI30663, R01AI030663)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: IL-17-producing T cells, TGF-β1, Th17 cell differentiation, regulatory T cells, interleukin-6, TLR3, TLR4, TLR9, IL-1β, TNF-α, IL-23, GATA3, T-bet, Smad7, Th1/Th2 differentiation, naive CD4+ T cells, inflammatory cytokines
MeSH terms: Animals, Cell Differentiation, Cells, Cultured, Dendritic Cells, Membrane Glycoproteins, Mice, Inbred C57BL, Mice, Transgenic, T-Lymphocytes, CD4-Positive T-Lymphocytes, Lymphocyte Subsets, Cytokines, Transforming Growth Factor beta, Receptors, Interleukin-1, Mice, Knockout, Th1 Cells, Th2 Cells, Interleukin-17, T-Lymphocytes, Regulatory, Mice, Smad7 Protein, Transforming Growth Factor beta1

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TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

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