The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Initial Events in Establishing Vaginal Entry and Infection by Human Immunodeficiency Virus Type-1
Open accessAbstract
Understanding the initial events in the establishment of vaginal human immunodeficiency virus type-1 (HIV-1) entry and infection has been hampered by the lack of appropriate experimental models. Here, we show in an ex vivo human organ culture system that upon contact in situ, HIV-1 rapidly penetrated both intraepithelial vaginal Langerhans and CD4(+) T cells. HIV-1 entered CD4(+) T cells almost exclusively by CD4 and CCR5 receptor-mediated direct fusion, without requiring passage from Langerhans cells, and overt productive infection ensued. By contrast, HIV-1 entered CD1a(+) Langerhans cells primarily by endocytosis, by means of multiple receptors, and virions persisted intact within the cytoplasm for several days. Our findings shed light on the very earliest steps of mucosal HIV infection in vivo and may guide the design of effective strategies to block local transmission and prevent HIV-1 spread.
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Cites
Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions
McDonald, D., Wu, L., Bohks, S. M., KewalRamani, V. N., Unutmaz, D., & Hope, T. J. (2003) · Science · doi:10.1126/science.1084238 · Cited by 707
Capsid Is a Dominant Determinant of Retrovirus Infectivity in Nondividing Cells
Yamashita, M., & Emerman, M. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5670-5678.2004 · Cited by 325
Arrighi, J.-F., Pion, M., Garcia, E., Escola, J.-M., van Kooyk, Y., Geijtenbeek, T. B., & Piguet, V. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041356 · Cited by 240
Cited by
Keele, B. F., Giorgi, E. E., Salazar-Gonzalez, J. F., Decker, J. M., Pham, K. T., Salazar, M. G., Sun, C., Grayson, T., Wang, S., Li, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802203105 · Cited by 1,912
Avoiding the void: Cell-to-cell spread of human viruses
Sattentau, Q. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1972 · Cited by 614
Phenotypic properties of transmitted founder HIV-1
Parrish, N. F., Gao, F., Li, H., Giorgi, E. E., Barbian, H. J., Parrish, E. H., Zajic, L., Iyer, S. S., Decker, J. M., Kumar, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304288110 · Cited by 422
Ochsenbauer, C., Edmonds, T. G., Ding, H., Keele, B. F., Decker, J., Salazar, M. G., Salazar-Gonzalez, J. F., Shattock, R., Haynes, B. F., Shaw, G. M., et al. (2012) · Journal of Virology · doi:10.1128/jvi.06157-11 · Cited by 342
High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men
Li, H., Bar, K. J., Wang, S., Decker, J. M., Chen, Y., Sun, C., Salazar-Gonzalez, J. F., Salazar, M. G., Learn, G. H., Morgan, C. J., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000890 · Cited by 297
Metadata
- Authors
- Hladik, F., Sakchalathorn, P., Ballweber, L., Lentz, G., Fialkow, M., Eschenbach, D., & McElrath, M. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 26
- Issue
- 2
- Pages
- 257-270
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2149317992
- Cited by
- 498
- References
- 3
- FWCI
- 16.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hladik, F., Sakchalathorn, P., Ballweber, L., Lentz, G., Fialkow, M., Eschenbach, D., & McElrath, M. J. (2007). Initial Events in Establishing Vaginal Entry and Infection by Human Immunodeficiency Virus Type-1. Immunity. https://doi.org/10.1016/j.immuni.2007.01.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
