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Cited by 422

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Phenotypic properties of transmitted founder HIV-1

Open access
Parrish, Nicholas F., Gao, Feng, Li, Hui, Giorgi, Elena E., Barbian, Hannah J., Parrish, Erica H., Zajic, Lara, Iyer, Shilpa S., Decker, Julie M., Kumar, Amit, Hora, Bhavna, Berg, Anna, Cai, Fangping, Hopper, Jennifer, Denny, Thomas N., Ding, Haitao, Ochsenbauer, Christina, Kappes, John C., Galimidi, Rachel P., West, Anthony P., Bjorkman, Pamela J., Wilen, Craig B., Doms, Robert W., O’Brien, Meagan, Bhardwaj, Nina, Borrow, Persephone, Haynes, Barton F., Muldoon, Mark, Theiler, James P., Korber, Bette, Shaw, George M., Hahn, Beatrice H.·2013·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1304288110
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Abstract

Defining the virus–host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo infections, could be important for AIDS vaccine development. Previous analyses have failed to identify phenotypic properties other than chemokine receptor 5 (CCR5) and CD4+ T-cell tropism that are preferentially associated with viral transmission. However, most of these studies were limited to examining envelope (Env) function in the context of pseudoviruses. Here, we generated infectious molecular clones of transmitted founder (TF; n = 27) and chronic control (CC; n = 14) viruses of subtypes B ( n = 18) and C ( n = 23) and compared their phenotypic properties in assays specifically designed to probe the earliest stages of HIV-1 infection. We found that TF virions were 1.7-fold more infectious ( P = 0.049) and contained 1.9-fold more Env per particle ( P = 0.048) compared with CC viruses. TF viruses were also captured by monocyte-derived dendritic cells 1.7-fold more efficiently ( P = 0.035) and more readily transferred to CD4+ T cells ( P = 0.025). In primary CD4+ T cells, TF and CC viruses replicated with comparable kinetics; however, when propagated in the presence of IFN-α, TF viruses replicated to higher titers than CC viruses. This difference was significant for subtype B ( P = 0.000013) but not subtype C ( P = 0.53) viruses, possibly reflecting demographic differences of the respective patient cohorts. Together, these data indicate that TF viruses are enriched for higher Env content, enhanced cell-free infectivity, improved dendritic cell interaction, and relative IFN-α resistance. These viral properties, which likely act in concert, should be considered in the development and testing of AIDS vaccines.

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Metadata

Authors
Parrish, N. F., Gao, F., Li, H., Giorgi, E. E., Barbian, H. J., Parrish, E. H., Zajic, L., Iyer, S. S., Decker, J. M., Kumar, A., Hora, B., Berg, A., Cai, F., Hopper, J., Denny, T. N., Ding, H., Ochsenbauer, C., Kappes, J. C., Galimidi, R. P., West, A. P., Bjorkman, P. J., Wilen, C. B., Doms, R. W., O’Brien, M., Bhardwaj, N., Borrow, P., Haynes, B. F., Muldoon, M., Theiler, J. P., Korber, B., Shaw, G. M., & Hahn, B. H.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2013-03-29
Volume
110
Issue
17
Pages
6626-6633
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1304288110
OpenAlex
W2007089157
Cited by
422
References
69
FWCI
21.13
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Phenotypic properties of transmitted founder HIV-1. https://app.cochat.ai/papers/10.1073/pnas.1304288110
The paper
Parrish, N. F., Gao, F., Li, H., Giorgi, E. E., Barbian, H. J., Parrish, E. H., Zajic, L., Iyer, S. S., Decker, J. M., Kumar, A., Hora, B., Berg, A., Cai, F., Hopper, J., Denny, T. N., Ding, H., Ochsenbauer, C., Kappes, J. C., Galimidi, R. P., . . . Hahn, B. H. (2013). Phenotypic properties of transmitted founder HIV-1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1304288110

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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