The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Innate and Adaptive Immunity through Autophagy
Open accessAbstract
The two main proteolytic machineries of eukaryotic cells, lysosomes and proteasomes, receive substrates by different routes. Polyubiquitination targets proteins for proteasomal degradation, whereas autophagy delivers intracellular material for lysosomal hydrolysis. The importance of autophagy for cell survival has long been appreciated, but more recently, its essential role in both innate and adaptive immunity has been characterized. Autophagy is now recognized to restrict viral infections and replication of intracellular bacteria and parasites. Additionally, this pathway delivers cytoplasmic antigens for MHC class II presentation to the adaptive immune system, which then in turn is able to regulate autophagy. At the same time, autophagy plays a role in the survival and the cell death of T cells. Thus, the immune system utilizes autophagic degradation of cytoplasmic material, to both restrict intracellular pathogens and regulate adaptive immunity.
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Cites
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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Loss of autophagy in the central nervous system causes neurodegeneration in mice
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de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033 · cited 1×
“For lysosomes, autophagy delivers intracellular constituents for degradation, but how autophagosome cargo is selected remains unclear (De Duve and Wattiaux, 1966) .”
BackgroundGutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252
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Molecular dissection of autophagy: two ubiquitin-like systems
Ohsumi, Y. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056522 · Cited by 1,240 · cited 1×
“In this process, cytosolic constituents are enclosed in a double-membrane vesicle, called autophagosome (Fengsrud et al., 2000a; Stromhaug et al., 1998), which then fuses with lysosomes and late endosomes for degradation of the inner autophagosomal membrane and its cargo (Ohsumi, 2001) (Figure 1).”
BackgroundEndogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T., & Münz, C. (2005) · Science · doi:10.1126/science.1104904 · Cited by 860 · cited 3×
“…and model antigens, we have demonstrated that the viral antigen EBNA1 is processed intracellularly for MHC class II presentation to CD4+ T cells via macroautophagy in EBVtransformed B cells and EBNA1-transfected EBV-negative Hodgkin’s lymphoma cells (Münz et al., 2000; Paludan et al., 2005).”
Self-citationHSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein
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Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network
Kihara, A., Kabeya, Y., Ohsumi, Y., & Yoshimori, T. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve061 · Cited by 813
Cited by
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583
Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190
Metadata
- Authors
- Schmid, D., & Münz, C.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 27
- Issue
- 1
- Pages
- 11-21
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2046428284
- Cited by
- 425
- References
- 17
- FWCI
- 27.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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