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Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10
Open accessAbstract
Transforming growth factor-beta (TGF-beta) and interleukin-10 (IL-10) are regulatory cytokines with pleiotropic roles in the immune system. The prominent function of TGF-beta is to maintain T cell tolerance to self or innocuous environmental antigens via its direct effects on the differentiation and homeostasis of effector and regulatory T cells. A critical route for the regulation of T cells by TGF-beta is via activation of a T cell-produced latent form of TGF-beta1 by dendritic cell-expressed avbeta8 integrin. IL-10 operates primarily as a feedback inhibitor of exuberant T cell responses to microbial antigens. T cells are also the principal producers of IL-10, the expression of which is regulated by IL-27, IL-6, and TGF-beta. The collective activity of TGF-beta and IL-10 ensures a controlled inflammatory response specifically targeting pathogens without evoking excessive immunopathology to self-tissues.
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“IL-10 can serve a key function in tolerance induction by keeping immune responses in check and preventing self tissue damage13–15.”
From The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance (2009) · cites this paper as [14]
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Cano, I., Worswick, J., Mulhearn, B., Green, M., Feist, S. W., & Clinton, M. (2021) · Pathogens · doi:10.3390/pathogens10050542 · Cited by 4
The Immune System and Inflammation in Type 2 Diabetes
García-Macedo, R., & Fortis, M. D. L. Á. (2023) · Springer eBooks · doi:10.1007/978-3-031-25519-9_12 · Cited by 6
Cerebrospinal Fluid Biomarkers of Simian Immunodeficiency Virus Encephalitis
Bissel, S. J., Kofler, J., Nyaundi, J., Murphey‐Corb, M., Wisniewski, S. R., & Wiley, C. A. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9666-9 · Cited by 4
New normal: two aspects of adipose tissue in COVID-19—treat and threat?
Çöpçü, H. E. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2020.1822812 · Cited by 4
Rao, S., Ahmed, S. A., & Sari, Y. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu019 · Cited by 4
RetractedMonk, J. M., & Woodward, B. D. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992443 · Cited by 4
Metadata
- Authors
- Li, M. O., & Flavell, R. A.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Li, Ming O.
- Flavell, Richard A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 28
- Issue
- 4
- Pages
- 468-476
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2019497869
- Cited by
- 501
- References
- 95
- Citations by year
- 2026: 18 · 2025: 30 · 2024: 27 · 2023: 23 · 2022: 25 · 2021: 20 · 2020: 27 · 2019: 25 · 2018: 23 · 2017: 15 · 2016: 25 · 2015: 23 · 2014: 31 · 2013: 34 · 2012: 24
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK51665, R01DK051665)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR060723)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- TGF-beta, IL-10, regulatory cytokines, T cell tolerance, regulatory T cells, effector T cells, dendritic cells, latent TGF-beta1, IL-27, interleukin-6, inflammation, immunopathology, self-tolerance
- MeSH terms
- Animals, Humans, Infections, Inflammation, T-Lymphocyte Subsets, Transforming Growth Factor beta, Interleukin-10, Inflammation Mediators, Feedback, Physiological, Mice
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