Cited by 501T-cell and B-cell ImmunologyTGF-β signaling in diseasesCytokine Signaling Pathways and Interactions

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Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

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Li, Ming O., Flavell, Richard A.·2008·Immunity

DOI 10.1016/j.immuni.2008.03.003

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Abstract

Transforming growth factor-beta (TGF-beta) and interleukin-10 (IL-10) are regulatory cytokines with pleiotropic roles in the immune system. The prominent function of TGF-beta is to maintain T cell tolerance to self or innocuous environmental antigens via its direct effects on the differentiation and homeostasis of effector and regulatory T cells. A critical route for the regulation of T cells by TGF-beta is via activation of a T cell-produced latent form of TGF-beta1 by dendritic cell-expressed avbeta8 integrin. IL-10 operates primarily as a feedback inhibitor of exuberant T cell responses to microbial antigens. T cells are also the principal producers of IL-10, the expression of which is regulated by IL-27, IL-6, and TGF-beta. The collective activity of TGF-beta and IL-10 ensures a controlled inflammatory response specifically targeting pathogens without evoking excessive immunopathology to self-tissues.

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Authors: Li, M. O., & Flavell, R. A.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Li, Ming O.
Flavell, Richard A.
ORCID: Li, Ming O.
Flavell, Richard A.
Venue: Immunity
Publisher: Elsevier BV
Published: 2008-04
Volume: 28
Issue: 4
Pages: 468-476
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2008.03.003
OpenAlex: W2019497869
Cited by: 501
References: 95
Citations by year: 2026: 18 · 2025: 30 · 2024: 27 · 2023: 23 · 2022: 25 · 2021: 20 · 2020: 27 · 2019: 25 · 2018: 23 · 2017: 15 · 2016: 25 · 2015: 23 · 2014: 31 · 2013: 34 · 2012: 24
FWCI: 3.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1933 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK51665, R01DK051665)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR060723)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: TGF-beta, IL-10, regulatory cytokines, T cell tolerance, regulatory T cells, effector T cells, dendritic cells, latent TGF-beta1, IL-27, interleukin-6, inflammation, immunopathology, self-tolerance
MeSH terms: Animals, Humans, Infections, Inflammation, T-Lymphocyte Subsets, Transforming Growth Factor beta, Interleukin-10, Inflammation Mediators, Feedback, Physiological, Mice

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Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

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