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Late Developmental Plasticity in the T Helper 17 Lineage
Open accessAbstract
Development of T helper (Th) 17 cells requires transforming growth factor (TGF)-beta and interleukin (IL)-6 and is independent of the Th1 pathway. Although T cells that produce interferon (IFN)-gamma are a recognized feature of Th17 cell responses, mice deficient for STAT4 and T-bet-two prototypical Th1 transcription factors-are protected from autoimmunity associated with Th17 pathogenesis. To examine the fate and pathogenic potential of Th17 cells and origin of IFN-gamma-producing T cells that emerge during Th17 immunity, we developed IL-17F reporter mice that identify cells committed to expression of IL-17F and IL-17A. Th17 cells required TGF-beta for sustained expression of IL-17F and IL-17A. In the absence of TGF-beta, both IL-23 and IL-12 acted to suppress IL-17 and enhance IFN-gamma production in a STAT4- and T-bet-dependent manner, albeit with distinct efficiencies. These results support a model of late Th17 developmental plasticity with implications for autoimmunity and host defense.
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“Although it has been reported that IL-23 signaling is important for the maintenance of Th17 cells (18, 19, 21), we find that ongoing IL-6 signaling is indispensable and foundational, acting upstream of IL-23 via its unique function to sustain RORγt expression and thereby IL-23R expression.”
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“In contrast to Th1 and Th2 cells, Th17 cells show substantially greater plasticity (19, 23, 65).”
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“IL-23 has been reported to be a trophic factor for Th17 cells (19, 23, 65), but IL-23 signaling also promotes the transdifferentiation of Th17 cells to Th1-like cells (19, 26)”
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Metadata
- Authors
- Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Weaver, Casey T.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 30
- Issue
- 1
- Pages
- 92-107
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3607320
- OpenAlex
- W2011882192
- Cited by
- 1,053
- References
- 62
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 18 · 2023: 32 · 2022: 47 · 2021: 42 · 2020: 47 · 2019: 46 · 2018: 35 · 2017: 56 · 2016: 48 · 2015: 82 · 2014: 81 · 2013: 85 · 2012: 90
- FWCI
- 56.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1694 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Comprehensive Cancer Center, University of Alabama at Birmingham
- National Institute of Allergy and Infectious Diseases (R01AI077574, R01AI035783)
- National Institute of Diabetes and Digestive and Kidney Diseases (R24DK064400, P01DK071176)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- Th17 cells, T helper cell differentiation, developmental plasticity, TGF-beta, interleukin-6, IL-17F, IL-17A, interferon-gamma, STAT4, T-bet, IL-23, IL-12, autoimmunity, Th1 cells
- MeSH terms
- Animals, Cells, Cultured, Flow Cytometry, Interferon-gamma, T-Lymphocyte Subsets, Transforming Growth Factor beta, Mice, Knockout, Th1 Cells, Th2 Cells, Cell Lineage, Interleukin-17, Mice, Interleukin-23
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