Late Developmental Plasticity in the T Helper 17 Lineage

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

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Transforming growth factor-β induces development of the TH17 lineage

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

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Interleukin-17 Family Members and Inflammation

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A sharp decrease of Th17, CXCR3+-Th17, and Th17.1 in peripheral blood is associated with an early anti-IL-17-mediated clinical remission in psoriasis

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Are Th17 Cells an Appropriate New Target in the Treatment of Rheumatoid Arthritis?

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Interleukin‐1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed‐Pattern Psoriasis

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J‐LEAPS peptide and LEAPS dendritic cell vaccines

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Th17 Cells Demonstrate Stable Cytokine Production in a Proallergic Environment

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Anti-leukemic properties of IL-12, IL-23 and IL-27: Differences and similarities in the control of pediatric B acute lymphoblastic leukemia

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Cholera Toxin Directly Enhances IL-17A Production from Human CD4+ T Cells

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Emerging roles of the Th17/IL-17-axis in glomerulonephritis

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The role of Th17 cells in chronic lymphocytic leukemia: friend or foe?

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TH17 cell: a double-edged sword in the development of inflammatory bowel disease

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Cell–Cell Interaction with APC, not IL-23, Is Required for Naive CD4 Cells To Acquire Pathogenicity during Th17 Lineage Commitment

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Targeting pathogenic T helper cell memory

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Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

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Total Recall: Intestinal TRM Cells in Health and Disease

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Circadian Rhythm Modulation of Microbes During Health and Infection

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The binding activity of Mel‐18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines

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HIPK2 directs cell type–specific regulation of STAT3 transcriptional activity in Th17 cell differentiation

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Identification of CFHR4 as a Potential Prognosis Biomarker Associated With lmmune Infiltrates in Hepatocellular Carcinoma

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Exploring Colitis through Dynamic T Cell Adoptive Transfer Models

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Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4+ T-cell development and allergic airway disease

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An IL-17F.S65L Knock-In Mouse Reveals Similarities and Differences in IL-17F Function in Oral Candidiasis: A New Tool to Understand IL-17F

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Neuroinflammation at single cell level: What is new?

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The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation

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The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation

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Epigenetic repolarization of T lymphocytes from chronic lymphocytic leukemia patients using 5-aza-2′-deoxycytidine

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Analysis of IL-17 gene polymorphisms in Chinese patients with dilated cardiomyopathy

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Modeling the Role of TGF-β in Regulation of the Th17 Phenotype in the LPS-Driven Immune System

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Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model

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TGF-β can leave you breathless

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Regulation of cardiac fibroblasts by lymphocytes after a myocardial infarction: playing in the major league

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IL-17 Control of Cutaneous Immune Homeostasis

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STAT4 gene polymorphisms in human diseases

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Functionally distinct IFN‐γ + IL‐17A + Th cells in experimental autoimmune uveitis: T‐cell heterogeneity, migration, and steroid response

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TIR-domain-containing adapter-inducing interferon-β (TRIF) regulates Th17-mediated intestinal immunopathology in colitis

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Therapeutic effect of anti-αv integrin mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease

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Cell-Mediated Defense against Infection

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Importance of Th22 Cell Disequilibrium in Immune Thrombocytopenic Purpura

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Interleukin-1β-induced IRAK1 ubiquitination is required for TH-GM-CSF cell differentiation in T cell-mediated inflammation

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Th17 pathway in recent-onset autoimmune diabetes

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Plasticity of Immunological Synapses

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A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction

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Tc17 CD8+ T cells accumulate in murine atherosclerotic lesions, but do not contribute to early atherosclerosis development

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Increased Synapse Formation Obtained by T Cell Epitopes Containing a CxxC Motif in Flanking Residues Convert CD4+ T Cells into Cytolytic Effectors

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Activated, Pro-Inflammatory Th1, Th17, and Memory CD4+ T Cells and B Cells Are Involved in Delayed-Type Hypersensitivity Arthritis (DTHA) Inflammation and Paw Swelling in Mice

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Role of IL‐10 and IL‐22 cytokines in patients with primary immune thrombocytopenia and their clinical significance

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Requirement of GATA-binding protein 3 for Il13 gene expression in IL-18-stimulated Th1 cells

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Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients

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The dichotomy of T helper 17 cells in cancer

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Aggregatibacter actinomycetemcomitans lipopolysaccharide stimulated epithelial cells produce interleukin-15 that regulates T cell activation

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RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and colonic inflammation

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Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration

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Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

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Human CCR6+ Th Cells Show Both an Extended Stable Gradient of Th17 Activity and Imprinted Plasticity

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EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin

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Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype

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TH17 cells mediate pulmonary collateral priming

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Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE

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Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis

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Naïve Primary Mouse CD8+ T Cells Retain In Vivo Immune Responsiveness After Electroporation-Based CRISPR/Cas9 Genetic Engineering

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Comparison of a classical Th1 bacteria versus a Th17 bacteria as adjuvant in the induction of experimental autoimmune encephalomyelitis

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Modeling a Complex Disease

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Exploitable Signaling Pathways for the Treatment of Inflammatory Bowel Disease

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Correlations between alterations of T-helper 17 cells and treatment efficacy after concurrent radiochemotherapy in locally advanced cervical cancer (stage IIB–IIIB): a 3-year prospective study

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Inducible IL10+ Suppressor B Cells Inhibit CNS Inflammation and T Helper 17 Polarization

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Th17 cells in systemic lupus erythematosus share functional features with Th17 cells from normal bone marrow and peripheral tissues

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To Help or To Harm

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Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence

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Single-cell multiomics reveals macrophage-derived IL-23 and CXCL9/10 drive pathogenic IFNG + IL17 + T cells in immunotherapy-related colitis

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CCL20-CCR6 signaling alters the metabolic reprogramming to promote the pathogenic Th17 cell differentiation

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Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation

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Assessing T lymphocyte function and differentiation by genetically encoded reporter systems

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An antitumor boost to TH9 cells

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DNA demethylation fine‐tunes IL‐2 production during thymic regulatory T cell differentiation

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Alpha4 beta7 integrin controls Th17 cell trafficking in the spinal cord leptomeninges during experimental autoimmune encephalomyelitis

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Revisiting the follicular helper T cell paradigm

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Therapeutic gene silencing with siRNA for IL-23 but not for IL-17 suppresses the development of experimental autoimmune encephalomyelitis in rats

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Novel regulatory Th17 cells and regulatory B cells in modulating autoimmune diseases

Singh, B., Summers, K. L., & Kerfoot, S. M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.09.002 · Cited by 10

Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD

Zaiken, M. C., Jin, S., McDonald-Hyman, C. S., Hartigan, C. R., Sage, P. T., Hippen, K. L., Koehn, B. H., Panoskaltsis‐Mortari, A., Riddle, M. J., Eide, C. R., et al. (2025) · Blood · doi:10.1182/blood.2024025036 · Cited by 8

IL-6-inducing Whole Yeast-based Immunotherapy Directly Controls IL-12-dependent CD8 T-cell Responses

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In vitro Immunomodulatory Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells on Peripheral Blood Cells from Warm Autoimmune Hemolytic Anemia Patients

Ma, C.-Y., Feng, Y.-N., Yang, L., Wang, S., Sun, X., Tai, S., Guan, X.-Z., Wang, D., & Yu, Y. (2021) · Acta Haematologica · doi:10.1159/000506759 · Cited by 8

Characterization of peripheral T helper 17 (Th17) cells phenotype in postmenopausal women with estrogen insufficiency

Bhadricha, H., Patel, V. V., Patil, A. D., Surve, S. V., & Desai, M. P. (2022) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2022.102702 · Cited by 8

The role of interleukin-23 in stability of in vitro T helper-17 cells.

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Cutting Edge: Hypoxia-Induced Ubc9 Promoter Hypermethylation Regulates IL-17 Expression in Ulcerative Colitis

Kumar, R., Singh, A. K., Starokadomskyy, P., Luo, W., Theiss, A. L., Burstein, E., & Venuprasad, K. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000015 · Cited by 8

Overexpressing Kallistatin Aggravates Experimental Autoimmune Uveitis Through Promoting Th17 Differentiation

Chen, N., Chen, S., Zhang, Z., Cui, X., Wu, L., Guo, K., Shao, H., Ma, J., & Zhang, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.756423 · Cited by 8

Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide—Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice

Nawrocki, M., Lory, N. C., Bedke, T., Stumme, F., Diercks, B., Guse, A. H., Meier, C., Gagliani, N., Mittrücker, H., & Huber, S. (2021) · Cells · doi:10.3390/cells10113039 · Cited by 8

The Role of T-Helper Cells in Atherosclerosis

Lu, X., Lu, D., Narayan, U., & Kakkar, V. V. (2011) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/187152511794182819 · Cited by 8

Sexual dimorphism in the aged rat CD4+ T lymphocyte-mediated immune response elicited by inoculation with spinal cord homogenate.

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Type II Activation of Macrophages and Microglia by Immune Complexes Enhances Th17 Biasing in an IL-6-Independent Manner

Stone, S., & Flamme, A. C. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164454 · Cited by 7

The Role of Th17 Cells in Immunopathogenesis of Neuroinflammatory Disorders

Pourgholaminejad, A., & Tahmasebinia, F. (2019) · Contemporary clinical neuroscience · doi:10.1007/978-3-030-19515-1_3 · Cited by 8

CD4+T Lymphocytes

Mowat, A. M., & Garside, P. (2010) · Wiley eBooks · doi:10.1002/9780470688618.taw0101 · Cited by 8

Th17 Cells: Orchestrators of Mucosal Inflammation and Potential Therapeutic Targets

Iraji, D., Oftedal, B. E., & Wolff, A. S. B. (2023) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2023050360 · Cited by 7

Impact of cardiac resynchronization therapy on circulating IL-17 producing cells in patients with advanced heart failure

Martins, S., Carvalheiro, T., Laranjeira, P., Martinho, A., Elvas, L., Gonçalves, L. M. M., Tomaz, C. T., António, N., & Paiva, A. A. (2018) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-018-0491-3 · Cited by 7

Increased interleukin-26 in the peripheral joints of patients with axial spondyloarthritis and psoriatic arthritis, co-localizing with CD68-positive synoviocytes

Hammitzsch, A., Ossadnik, A., Bachmann, Q., Merwald-Fraenk, H., Lorenz, G., Witt, M., Wiesent, F., Mühlhofer, H., Simone, D., Bowness, P., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1355824 · Cited by 7

Innate lymphocytes induce inflammatory bowel disease

Diefenbach, A., & Vonarbourg, C. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.82 · Cited by 7

Signaling Pathways and Epigenetic Regulations in the Control ofRORγtExpression in T Helper 17 Cells

Tian, Y., Wu, Y., & Ni, B. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.911858 · Cited by 7

Lagochilascaris minor: Susceptibility and Resistance to Experimental Infection in Mice Is Independent of H-2aHaplotype and Correlates with the Immune Response in Immunized Animals

Ferreira, M. S., Fernandes, L. C., Pfrimer, I. A. H., Pichiteli, C. R., Tambourgi, D. V., Júnior, R. D. S. L., & Carvalhaes, M. S. (2010) · Journal of Parasitology Research · doi:10.1155/2010/610457 · Cited by 7

Alternaria alternata acts on human Monocyte-derived Dendritic cells to mediate Th2/Th17 polarisation

Loghmani, A., Raoofi, R., Ownagh, A., & Delirezh, N. (2016) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2016.07.005 · Cited by 7

One road to the TH17 pathway: how TH1 led to TH17 (and vice versa), and first came last

Weaver, C. T. (2020) · Nature Immunology · doi:10.1038/s41590-020-0715-4 · Cited by 7

Helminth‐induced regulation of T‐cell transfer colitis requires intact and regulated T cell Stat6 signaling in mice

Metwali, A., Winckler, S., Urban, J. F., Kaplan, M. H., Ince, M. N., & Elliott, D. E. (2020) · European Journal of Immunology · doi:10.1002/eji.201848072 · Cited by 7

Interleukin 23 in IBD Pathogenesis

Eken, A., & Oukka, M. (2016) · InTech eBooks · doi:10.5772/64882 · Cited by 7

T-bet and Runx transcription factors are required for the ontogeny of pathogenic IFNγ-producing Th17 cells (LYM3P.729)

Lazarevic, V., Wang, Y., Godec, J., Ben-Aissa, K., Cui, K., Zhao, K., Pucsek, A. B., Weaver, C. T., & Yagi, R. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.192.supp.64.3

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742

The Transcription Factors T-bet and Runx Are Required for the Ontogeny of Pathogenic Interferon-γ-Producing T Helper 17 Cells

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Generation of pathogenic TH17 cells in the absence of TGF-β signalling

Ghoreschi, K., Laurence, A., Yang, X.-P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L., Wei, L., Davidson, T. S., Bouladoux, N., et al. (2010) · Nature · doi:10.1038/nature09447 · Cited by 1,388

Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation

Das, J., Ren, G., Zhang, L., Roberts, A. I., Zhao, X., Bothwell, A. L. M., Kaer, L. V., Shi, Y., & Das, G. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082286 · Cited by 222