The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Late Developmental Plasticity in the T Helper 17 Lineage
Open accessAbstract
Development of T helper (Th) 17 cells requires transforming growth factor (TGF)-beta and interleukin (IL)-6 and is independent of the Th1 pathway. Although T cells that produce interferon (IFN)-gamma are a recognized feature of Th17 cell responses, mice deficient for STAT4 and T-bet-two prototypical Th1 transcription factors-are protected from autoimmunity associated with Th17 pathogenesis. To examine the fate and pathogenic potential of Th17 cells and origin of IFN-gamma-producing T cells that emerge during Th17 immunity, we developed IL-17F reporter mice that identify cells committed to expression of IL-17F and IL-17A. Th17 cells required TGF-beta for sustained expression of IL-17F and IL-17A. In the absence of TGF-beta, both IL-23 and IL-12 acted to suppress IL-17 and enhance IFN-gamma production in a STAT4- and T-bet-dependent manner, albeit with distinct efficiencies. These results support a model of late Th17 developmental plasticity with implications for autoimmunity and host defense.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“Although it has been reported that IL-23 signaling is important for the maintenance of Th17 cells (18, 19, 21), we find that ongoing IL-6 signaling is indispensable and foundational, acting upstream of IL-23 via its unique function to sustain RORγt expression and thereby IL-23R expression.”
From T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity (2020) · cites this paper as [19]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In contrast to Th1 and Th2 cells, Th17 cells show substantially greater plasticity (19, 23, 65).”
From T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity (2020) · cites this paper as [19]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“IL-23 has been reported to be a trophic factor for Th17 cells (19, 23, 65), but IL-23 signaling also promotes the transdifferentiation of Th17 cells to Th1-like cells (19, 26)”
From T H 17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity (2020) · cites this paper as [19]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
Self-citationA distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Self-citationCua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906
Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K. P., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00070-4 · Cited by 2,819
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371
Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,210
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Susan, M. L., Gong, Q., Abbas, A. R., Modrusan, Z. D., Ghilardi, N., de Sauvage, F. J., et al. (2008) · Nature Medicine · doi:10.1038/nm1720 · Cited by 1,972
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,896
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D. M., Valdez, P. A., Kasman, I. M., Eastham‐Anderson, J., Wu, J., & Ouyang, W. (2006) · Nature · doi:10.1038/nature05505 · Cited by 1,888
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861
Aggarwal, S., Ghilardi, N., Xie, M.-H., de Sauvage, F. J., & Gurney, A. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207577200 · Cited by 1,848
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
Self-citationDivergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669
T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
Yang, X. O., Panopoulos, A. D., Nurieva, R., Chang, S. H., Wang, D., Watowich, S. S., & Dong, C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c600321200 · Cited by 1,530
McGeachy, M. J., Bak-Jensen, K. S., Chen, Y., Tato, C. M., Blumenschein, W., McClanahan, T., & Cua, D. J. (2007) · Nature Immunology · doi:10.1038/ni1539 · Cited by 1,520
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507
Khader, S. A., Bell, G. K., Pearl, J. E., Fountain, J. J., Rangel‐Moreno, J., Cilley, G. E., Shen, F., Eaton, S. M., Gaffen, S. L., Swain, S. L., et al. (2007) · Nature Immunology · doi:10.1038/ni1449 · Cited by 1,468
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
Weaver, C. T., Harrington, L. E., Mangan, P. R., Gavrieli, M., & Murphy, K. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.002 · Cited by 1,422
Self-citationParham, C. L., Chirica, M., Timans, J., Vaisberg, E., Travis, M. A., Cheung, J., Pflanz, S., Zhang, R. V., Singh, K. P., Vega, F., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5699 · Cited by 1,314
Ferber, I., Brocke, S., Taylor-Edwards, C., Ridgway, W., Dinisco, C., Steinman, L., Dalton, D., & Fathman, C. (1996) · Journal of Immunology · doi:10.4049/jimmunol.156.1.5 · Cited by 1,088
Powrie, F., Leach, M. W., Mauze, S., Caddie, L. B., & Coffman, R. L. (1993) · International Immunology · doi:10.1093/intimm/5.11.1461 · Cited by 1,078
Powrie, F. M., Carlino, J. A., Leach, M. W., Mauze, S., & Coffman, R. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2669 · Cited by 894
Batten, M., Li, J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J., de Sauvage, F. J., & Ghilardi, N. (2006) · Nature Immunology · doi:10.1038/ni1375 · Cited by 835
Understanding the IL-23–IL-17 immune pathway
McKenzie, B. S., Kastelein, R. A., & Cua, D. J. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.10.003 · Cited by 771
Differentiation and function of Th17 T cells
Stockinger, B., & Veldhoen, M. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.04.005 · Cited by 736
Th17 Cell Differentiation: The Long and Winding Road
McGeachy, M. J., & Cua, D. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.001 · Cited by 712
Willenborg, D. O., Fordham, S. A., Bernard, C. C. A., Cowden, W. B., & Ramshaw, I. A. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.8.3223 · Cited by 636
Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.589 · Cited by 613
Neurath, M. F., Weigmann, B., Finotto, S., Glickman, J. N., Nieuwenhuis, E. E. S., Iijima, H., Mizoguchi, A., Mizoguchi, E., Mudter, J., Galle, P. R., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011956 · Cited by 606
Maynard, C. L., Harrington, L. E., Janowski, K. M., Oliver, J. R., Zindl, C. L., Rudensky, A. Y., & Weaver, C. T. (2007) · Nature Immunology · doi:10.1038/ni1504 · Cited by 599
Self-citationHarris, T. J., Grosso, J. F., Yen, H., Xin, H., Kortylewski, M., Albesiano, E., Hipkiss, E. L., Getnet, D., Goldberg, M. V., Maris, C. H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4313 · Cited by 592
Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells
Mathur, A. N., Chang, H., Zisoulis, D. G., Stritesky, G. L., Yu, Q., O’Malley, J. T., Kapur, R., Levy, D. E., Kansas, G. S., & Kaplan, M. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4901 · Cited by 563
Chen, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25308 · Cited by 560
Hymowitz, S. G., Filvaroff, E. H., Yin, J., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R. F., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5332 · Cited by 548
Loss of T-bet, But Not STAT1, Prevents the Development of Experimental Autoimmune Encephalomyelitis
Bettelli, E., Sullivan, B., Szabo, S. J., Sobel, R., Glimcher, L., & Kuchroo, V. (2004) · Journal of Experimental Medicine · doi:10.1084/jem.20031819 · Cited by 546
The IL-27R (WSX-1) Is Required to Suppress T Cell Hyperactivity during Infection
Villarino, A. V., Hibbert, L., Lieberman, L. A., Wilson, E. H., Mak, T. W., Yoshida, H., Kastelein, R. A., Saris, C. J. M., & Hunter, C. A. (2003) · Immunity · doi:10.1016/s1074-7613(03)00300-5 · Cited by 484
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12.
Becher, B., Durell, B., & Noelle, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15751 · Cited by 481
Role of Th1 and Th17 cells in organ-specific autoimmunity
Dardalhon, V., Korn, T., Kuchroo, V. K., & Anderson, A. C. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.04.017 · Cited by 460
Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice
Elson, C. O., Cong, Y., Weaver, C. T., Schoeb, T. R., McClanahan, T. K., Fick, R. B., & Kastelein, R. A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.104 · Cited by 453
Self-citationInterleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
Ízcue, A., Hüe, S., Buonocore, S. M., Arancibia-Cárcamo, C. V., Ahern, P. P., Iwakura, Y., Maloy, K. J., & Powrie, F. M. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.019 · Cited by 418
Gran, B., Zhang, G., Yu, S., Li, J., Chen, X., Ventura, E. S., Kamoun, M., & Rostami, A. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.12.7104 · Cited by 405
Cutting Edge: TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression
Gorelik, L., Fields, P. E., & Flavell, R. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4773 · Cited by 391
Liang, S. C., Long, A. J., Bennett, F., Whitters, M. J., Karim, R., Collins, M. A., Goldman, S. J., Dunussi‐Joannopoulos, K., Williams, C. M. M., Wright, J. F., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7791 · Cited by 374
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
Becher, B., Durell, B. G., & Noelle, R. J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215751 · Cited by 355
Zhang, G., Gran, B., Yu, S., Li, J., Siglienti, I., Chen, X., Kamoun, M., & Rostami, A. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2153 · Cited by 305
Memory CD4 T cells emerge from effector T-cell progenitors
Harrington, L., Janowski, K., Oliver, J., Zajac, A., & Weaver, C. (2008) · Nature · doi:10.1038/nature06672 · Cited by 290
Self-citationA novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses
Chang, S. H., & Dong, C. (2007) · Cell Research · doi:10.1038/cr.2007.35 · Cited by 288
Chitnis, T., Najafian, N., Benou, C., Salama, A. D., Grusby, M. J., Sayegh, M. H., & Khoury, S. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12563 · Cited by 233
Lin, J. T., Martin, S. L., Xia, L., & Gorham, J. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.5950 · Cited by 170
IL-12– and IL-23–induced T helper cell subsets
Bettelli, E., & Kuchroo, V. K. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042279 · Cited by 144
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype
Mathur, A. N. (2006) · Blood · doi:10.1182/blood-2006-04-015016 · Cited by 143
T Helper 1 and T Helper 2 Cells Are Pathogenic in an Antigen-specific Model of Colitis
Iqbal, N., Oliver, J. R., Wagner, F. H., Lazenby, A. J., Elson, C. O., & Weaver, C. T. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.2001889 · Cited by 141
Self-citationLow dose TGF-beta attenuates IL-12 responsiveness in murine Th cells.
Gorham, J. D., Guler, M. L., Fenoglio, D., Gubler, U., & MURPHY, K. M. M. (1998) · PubMed · Cited by 116
Low Dose TGF-β Attenuates IL-12 Responsiveness in Murine Th Cells
Gorham, J. D., Guler, M. L., Fenoglio, D., Gubler, U., & MURPHY, K. M. M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.4.1664 · Cited by 98
Letimier, F. A., Passini, N., Gasparian, S., Bianchi, E., & Rogge, L. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601586 · Cited by 79
Flagged first, then by citations
Cited by
Sorted by citations
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Follicular Helper CD4 T Cells (T FH )
Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
Reciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598
Self-citationThe IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585
Metadata
- Authors
- Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Weaver, Casey T.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 30
- Issue
- 1
- Pages
- 92-107
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3607320
- OpenAlex
- W2011882192
- Cited by
- 1,053
- References
- 62
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 18 · 2023: 32 · 2022: 47 · 2021: 42 · 2020: 47 · 2019: 46 · 2018: 35 · 2017: 56 · 2016: 48 · 2015: 82 · 2014: 81 · 2013: 85 · 2012: 90
- FWCI
- 56.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1694 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Comprehensive Cancer Center, University of Alabama at Birmingham
- National Institute of Allergy and Infectious Diseases (R01AI077574, R01AI035783)
- National Institute of Diabetes and Digestive and Kidney Diseases (R24DK064400, P01DK071176)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- Th17 cells, T helper cell differentiation, developmental plasticity, TGF-beta, interleukin-6, IL-17F, IL-17A, interferon-gamma, STAT4, T-bet, IL-23, IL-12, autoimmunity, Th1 cells
- MeSH terms
- Animals, Cells, Cultured, Flow Cytometry, Interferon-gamma, T-Lymphocyte Subsets, Transforming Growth Factor beta, Mice, Knockout, Th1 Cells, Th2 Cells, Cell Lineage, Interleukin-17, Mice, Interleukin-23
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
