The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein
Open accessAbstract
Foxp3+ regulatory T (TR) cells limit pathogenic immune responses to self and foreign antigens. An essential role for microRNA (miRNA) in the maintenance and function of TR cells, revealed by the TR-specific Dicer ablation, raised a question as to a specific miRNA contribution. We found that Foxp3 controls the elevated miR155 expression required for maintaining TR proliferative activity and numbers under non-lymphopenic conditions. Moreover, miR155 deficiency in TR cells results in increased SOCS1 expression accompanied by impaired STAT5 activation in response to limiting amounts of IL-2. Our studies suggest Foxp3-dependent regulation of miR155 maintains competitive fitness of TR subset by targeting SOCS1, and provide an experimental support for a proposed role for miRNAs in ensuring the robustness of cellular phenotypes.
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Cites
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Self-citationRequirement of bic/microRNA-155 for Normal Immune Function
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SOCS proteins, cytokine signalling and immune regulation
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Self-citationRegulation of the Germinal Center Response by MicroRNA-155
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Self-citationCD4+CD25+ Immunoregulatory T Cells
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Cited by
Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Regulatory T cells: mechanisms of differentiation and function
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Self-citationPlasticity of CD4+ T Cell Lineage Differentiation
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Physiological and pathological roles for microRNAs in the immune system
O'Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature Reviews Immunology · doi:10.1038/nri2708 · Cited by 1,378
Metadata
- Authors
- Lu, L.-F., Thai, T.-H., Calado, D. P., Chaudhry, A., Kubo, M., Tanaka, K., Loeb, G. B., Lee, H., Yoshimura, A., Rajewsky, K., & Rudensky, A. Y.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 30
- Issue
- 1
- Pages
- 80-91
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2085441977
- Cited by
- 783
- References
- 39
- FWCI
- 24.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein. https://app.cochat.ai/papers/10.1016/j.immuni.2008.11.010
- The paper
- Lu, L.-F., Thai, T.-H., Calado, D. P., Chaudhry, A., Kubo, M., Tanaka, K., Loeb, G. B., Lee, H., Yoshimura, A., Rajewsky, K., & Rudensky, A. Y. (2009). Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein. Immunity. https://doi.org/10.1016/j.immuni.2008.11.010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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