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Cited by 3,751MicroRNA in disease regulationPlant Molecular Biology ResearchRNA Research and Splicing

Metazoan MicroRNAs

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Bartel, David P.·2018·Cell
DOI 10.1016/j.cell.2018.03.006PMC PMC6091663
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Abstract

MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals.

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Crossref · 10.1016/j.cell.2018.03.006

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  • miRNAs exert their repressive regulatory function by guiding RISC to complementary target sites in the 3′ UTR of target mRNAs, resulting in mRNA degradation, translation inhibition, or sequestration.

    “Generally, miRNAs exert their repressive regulatory function by guiding the RNA-induced silencing complex (RISC) to complementary target sites in the 3′ untranslated region (UTR) of target mRNAs resulting in mRNA degradation, translation inhibition, or sequestration (Bartel, 2018).”

    From Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP (2022) · cites this paper as Bartel, 2018

    The miRNA Target Recognition section describes pairing to sites in target mRNAs’ 3′ UTRs, and miRNA Regulatory Mechanisms describes Argonaute-mediated mRNA decay and reduced translation. The latter calls decay and translational repression the two repressive consequences of this regulatory mode; our copy does not support sequestration as a third consequence. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • RNA processing and miRNA-mediated gene silencing are fundamental mechanisms that fine-tune gene expression to regulate tissue development and physiology.

    “RNA processing and miRNA-mediated gene silencing are fundamental mechanisms that fine-tune gene expression to regulate tissue development and physiology (Kalsotra and Cooper 2011; Baralle and Giudice 2017; Bartel 2018; Marasco and Kornblihtt 2023)”

    From ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation (2025) · cites this paper as Bartel 2018

  • Small ncRNAs are endogenously expressed transcripts 18 to 200 nt long.

    “Small noncoding RNAs (ncRNAs) are a large family of endogenously expressed transcripts, 18 to 200 nt long”

    From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [1]

  • Small ncRNAs play a crucial role in regulating cell function.

    “that play a crucial role in regulating cell function (1, 2)”

    From A mouse tissue atlas of small noncoding RNA (2020) · cites this paper as [1]

  • microRNAs (miRNAs) regulate gene expression by targeting specific mRNAs for degradation or translational repression.

    “microRNAs (miRNAs) play a central role in the regulation of gene expression by targeting specific mRNAs for degradation or translational repression.”

    From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Bartel, 2018

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Authors
Bartel, D. P.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Bartel, David P.
ORCID
Bartel, David P.
Venue
Cell
Publisher
Elsevier BV
Published
2018-03
Volume
173
Issue
1
Pages
20-51
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2018.03.006
PMC
PMC6091663
OpenAlex
W4211064852
Cited by
3,751
References
30
Citations by year
2026: 370 · 2025: 404 · 2024: 437 · 2023: 536 · 2022: 544 · 2021: 557 · 2020: 460 · 2019: 326 · 2018: 114 · 2014: 1
FWCI
38.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institute of General Medical Sciences
  • National Institutes of Health
  • Howard Hughes Medical Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
microRNA, microRNA biogenesis, miRNA evolution, post-transcriptional regulation, microRNA function, mammals
MeSH terms
Animals, Gene Expression Regulation, Humans, Nucleic Acid Conformation, Evolution, Molecular, Base Pairing, Gene Silencing, Genomics, MicroRNAs, RNA Isoforms

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