The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo
Open accessAbstract
SUMMARY Although deficient CD8 T cell responses have long been associated with chronic viral infections, the underlying mechanisms are still unclear. Here we report that enhanced and sustained TGF-β/Smad signaling is a distinctive feature of virus-specific CD8 T cells during chronic versus acute viral infections in vivo. The result is TGF-β-dependent up-regulation of the pro-apoptotic protein Bim that relates to cell-intrinsic apoptosis and significantly reduced numbers of virus-specific CD8 T cells. Moreover, selective attenuation of TGF-β signaling on T cells increases the function of CD8 T cells in an indirect fashion, rapidly eradicates the persistence-prone virus and enables the generation of an effective memory response. Our findings reveal persisting TGF-β/Smad signaling as a hallmark and key regulator of virus-specific CD8 T cell responses during chronic viral infections in vivo.
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Cites
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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
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Cited by
Molecular and cellular insights into T cell exhaustion
Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
TGF-β Activation and Function in Immunity
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Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
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Living in the liver: hepatic infections
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Metadata
- Authors
- Tinoco, R., Alcalde, V., Yang, Y., Sauer, K., & Zuniga, E. I.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 31
- Issue
- 1
- Pages
- 145-157
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2066118264
- Cited by
- 261
- References
- 65
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tinoco, R., Alcalde, V., Yang, Y., Sauer, K., & Zuniga, E. I. (2009). Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo. Immunity. https://doi.org/10.1016/j.immuni.2009.06.015
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