The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.
TGF-β Activation and Function in Immunity
Open accessAbstract
The cytokine TGF-β plays an integral role in regulating immune responses. TGF-β has pleiotropic effects on adaptive immunity, especially in the regulation of effector and regulatory CD4 + T cell responses. Many immune and nonimmune cells can produce TGF-β, but it is always produced as an inactive complex that must be activated to exert functional effects. Thus, activation of latent TGF-β provides a crucial layer of regulation that controls TGF-β function. In this review, we highlight some of the important functional roles for TGF-β in immunity, focusing on its context-specific roles in either dampening or promoting T cell responses. We also describe how activation of TGF-β controls its function in the immune system, with a focus on the key roles for members of the integrin family in this process.
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“Together with IL-10, TGF-β is another powerful anti-inflammatory cytokine that acts on many target cells and tones down the inflammatory effects of TNF, IL-1β, IL-2, and IL-12, etc. (61, 67, 68).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [67]
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“TGF-β is a potent suppressor of both Th1 and Th2 cells, but foments the maintenance and function of Tregs (67, 69).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [67]
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“Importantly, TAMs induce immunosuppression via release of IL-10 and TGF-β, both of which inhibit the development of cytotoxic T cells and NK cells, and may fuel the appearance of more M2-like TAMs at the tumor site (8, 67, 90).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [67]
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Cites
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The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
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Cited by
Sorted by citations
Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
Arango Duque, G., & Descoteaux, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00491 · Cited by 2,708
“The capacity of M2c macrophages to induce Tregs makes them more effective than M2a macrophages at protecting organs from injury caused by inflammatory infiltrates (88).”
BackgroundInfluentialTransforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366
de Lange, K. M., Moutsianas, L., Lee, J. C., Lamb, C. A., Luo, Y., Kennedy, N. A., Jostins, L., Rice, D. L., Gutierrez-Achury, J., Ji, S.-G., et al. (2017) · Nature Genetics · doi:10.1038/ng.3760 · Cited by 1,445
TGF-β signaling in health and disease
Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890
Self-citationTGF-β1 Signaling and Tissue Fibrosis
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Metadata
- Authors
- Travis, M. A., & Sheppard, D.
- Affiliations
- Wellcome Centre for Cell-Matrix Research (GB)
- University of California, San Francisco (US)
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2014-03-21
- Volume
- 32
- Issue
- 1
- Pages
- 51-82
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- PMC
- PMC4010192
- OpenAlex
- W2125061065
- Semantic Scholar
- 66463ee09c2d582938e4fe5e4679ce7db83f5c99
- Cited by
- 856
- References
- 191
- Citations by year
- 2026: 62 · 2025: 75 · 2024: 82 · 2023: 79 · 2022: 90 · 2021: 88 · 2020: 71 · 2019: 72 · 2018: 70 · 2017: 67 · 2016: 54 · 2015: 34 · 2014: 12
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Pfizer
- GlaxoSmithKline
- Manchester Collaborative Centre for Inflammation Research
- National Institutes of Health (AI077439, HL108794)
- Directorate for Biological Sciences
- Medical Research Council
- National Heart, Lung, and Blood Institute (P01HL108794, HL108794, R01HL102292, HL102292, HL53947)
- National Institute of Allergy and Infectious Diseases (AI077439, U19AI077439)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- TGF-beta, latent TGF-beta activation, immune regulation, adaptive immunity, CD4+ T cells, regulatory T cells, effector T cells, integrins, cytokine signaling
- MeSH terms
- Animals, Dendritic Cells, Humans, Immune System, Immunity, Protein Binding, Signal Transduction, Integrins, T-Lymphocyte Subsets, Transforming Growth Factor beta, Adaptive Immunity
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