The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Regulatory T Cells in Asthma
Open accessAbstract
Asthma is characterized by T helper cell 2 (Th2) type inflammation, leading to airway hyperresponsiveness and tissue remodeling. Th2 cell-driven inflammation is likely to represent an abnormal response to harmless airborne particles. These reactions are normally suppressed by regulatory T cells, which maintain airway tolerance. The anti-inflammatory cytokine IL-10 is likely to play a central role. The role of the cytokine transforming growth factor β (TGF-β) is more complex, with evidence for immune suppression and remodeling in the airways. In asthmatic individuals there is a breakdown in these regulatory mechanisms. There is emerging evidence that early life events, including exposure to allergen and infections, are critical in programming effective regulatory pathways to maintain pulmonary homeostasis. In this review we examine the clinical and experimental evidence for T regulatory cell function in the lung and discuss the events that might influence the functioning of these cells. Ultimately, the ability to enhance regulatory function in affected individuals may represent an effective treatment for asthma.
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Citations
Cites
1 retracted
In utero supplementation with methyl donors enhances allergic airway disease in mice
Hollingsworth, J. W., Maruoka, S., Boon, K., Garantziotis, S., Li, Z., Tomfohr, J., Bailey, N., Potts, E. N., Whitehead, G., Brass, D. M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34378 · Cited by 331
RetractedHolick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
Chen, W., Jin, W., Hardegen, N., Lei, K.-J., Li, L., Marinos, N., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,699
Asthma and Wheezing in the First Six Years of Life
Martinez, F. D., Wright, A. L., Taussig, L. M., Holberg, C. J., Halonen, M., & Morgan, W. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320301 · Cited by 3,823
The global burden of asthma: executive summary of the GINA Dissemination Committee Report
Masoli, M., Fabian, D., Holt, S., Beasley, R., & Program, G. I. F. A. (. (2004) · Allergy · doi:10.1111/j.1398-9995.2004.00526.x · Cited by 3,529
Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
Bach, J.-F. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,687
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A.-K. L., & Flavell, R. A. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090737 · Cited by 2,206
Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586 · cited 1×
“Although IL-10 is not required for control of systemic autoimmunity, it is absolutely required for restraint of immune responses at mucosal surfaces such as the gut or lung (Rubtsov et al., 2008).”
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Cited by
Hardoim, P. R., van Overbeek, L. S., Berg, G., Pirttilä, A. M., Compant, S., Campisano, A., Döring, M., & Sessitsch, A. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00050-14 · Cited by 2,708
Environmental biodiversity, human microbiota, and allergy are interrelated
Hanski, I., von Hertzen, L., Fyhrquist, N., Koskinen, K., Torppa, K., Laatikainen, T., Karisola, P., Auvinen, P., Paulin, L., Mäkelä, M. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205624109 · Cited by 1,063
Jakobsson, H. E., Abrahamsson, T. R., Jenmalm, M. C., Harris, K., Quince, C., Jernberg, C., Björkstén, B., Engstrand, L., & Andersson, A. F. (2014) · Gut · doi:10.1136/gutjnl-2012-303249 · Cited by 1,011
Functions of T cells in asthma: more than just TH2 cells
Lloyd, C. M., & Hessel, E. M. (2010) · Nature Reviews Immunology · doi:10.1038/nri2870 · Cited by 578
Self-citationThe development and function of lung-resident macrophages and dendritic cells
Kopf, M., Schneider, C., & Nobs, S. P. (2015) · Nature Immunology · doi:10.1038/ni.3052 · Cited by 555
Metadata
- Authors
- Lloyd, C. M., & Hawrylowicz, C. M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 31
- Issue
- 3
- Pages
- 438-449
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2075951089
- Cited by
- 356
- References
- 119
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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