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Continuous Expression of the Transcription Factor E2-2 Maintains the Cell Fate of Mature Plasmacytoid Dendritic Cells
Open accessAbstract
Summary The interferon-producing plasmacytoid dendritic cells (pDCs) share common progenitors with antigen-presenting classical dendritic cells (cDCs), yet they possess distinct morphology and molecular features resembling those of lymphocytes. It is unclear whether the unique cell fate of pDCs is actively maintained in the steady state. We report that the deletion of transcription factor E2-2 from mature peripheral pDCs caused their spontaneous differentiation into cells with cDC properties. This included the loss of pDC markers, increase in MHC class II expression and T cell priming capacity, acquisition of dendritic morphology and induction of cDC signature genes. Genome-wide chromatin immunoprecipitation revealed direct binding of E2-2 to key pDC-specific and lymphoid genes, as well as to certain genes enriched in cDCs. Thus, E2-2 actively maintains the cell fate of mature pDCs and opposes the “default” cDC fate, in part through direct regulation of lineage-specific gene expression programs.
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Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190
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Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G. (2003) · Nature Immunology · doi:10.1038/ni925 · Cited by 351
Cited by
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Re(de)fining the dendritic cell lineage
Satpathy, A. T., Wu, X., Albring, J. C., & Murphy, K. M. (2012) · Nature Immunology · doi:10.1038/ni.2467 · Cited by 441
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Pozniak, J., Pedri, D., Landeloos, E., Van Herck, Y., Antoranz, A., Vanwynsberghe, L., Nowosad, A., Roda, N., Makhzami, S., Bervoets, G., et al. (2024) · Cell · doi:10.1016/j.cell.2023.11.037 · Cited by 199
Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells
Sawai, C. M., Sisirak, V., Ghosh, H. S., Hou, E. Z., Ceribelli, M., Staudt, L. M., & Reizis, B. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130443 · Cited by 133
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Metadata
- Authors
- Ghosh, H. S., Cisse, B., Bunin, A., Lewis, K. L., & Reizis, B.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 33
- Issue
- 6
- Pages
- 905-916
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2002051393
- Cited by
- 278
- References
- 2
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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