Cited by 351T-cell and B-cell ImmunologyDevelopmental Biology and Gene RegulationAcute Lymphoblastic Leukemia research

Bcl11a is essential for normal lymphoid development

Liu, Pentao, Keller, Jonathan R, Ortiz, Mariaestela, Tessarollo, Lino, Rachel, Rivka A, Nakamura, Takuro, Jenkins, Nancy A, Copeland, Neal G·2003·Nature Immunology

Abstract

Bcl11a (also called Evi9) functions as a myeloid or B cell proto-oncogene in mice and humans, respectively. Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis. Bcl11a mutant embryos lack B cells and have alterations in several types of T cells. Phenotypic and expression studies show that Bcl11a functions upstream of the transcription factors Ebf1 and Pax5 in the B cell pathway. Transplantation studies show that these defects in Bcl11a mutant mice are intrinsic to fetal liver precursor cells. Mice transplanted with Bcl11a-deficient cells died from T cell leukemia derived from the host. Thus, Bcl11a may also function as a non-autonomous T cell tumor suppressor gene.

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Crossref · 10.1038/ni925

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  • BCL11A's roles in other cell lineages, including B lymphocytes and the central nervous system, may present challenges.

    “However, its roles in other cell lineages, including B lymphocytes and the central nervous system, may present challenges (19, 20).”

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Authors
Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G.
Affiliations
  • National Cancer Institute (US)
  • Science Applications International Corporation (United States) (US)
  • Japanese Foundation For Cancer Research (JP)
Corresponding author
Copeland, Neal G
Venue
Nature Immunology
Published
2003-04-28
Volume
4
Issue
6
Pages
525-532
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
OpenAlex
W1998167494
Cited by
351
References
51
Citations by year
2026: 12 · 2025: 12 · 2024: 21 · 2023: 14 · 2022: 14 · 2021: 19 · 2020: 16 · 2019: 15 · 2018: 14 · 2017: 13 · 2016: 26 · 2015: 19 · 2014: 15 · 2013: 24 · 2012: 17
FWCI
3.64
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
  • National Institutes of Health (n01co12400-79-0-22)
  • National Cancer Institute (N01CO12400)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Keywords
BCL11A, lymphoid development, lymphocyte development, B cell development, T cell development, EBF1, PAX5, T-cell leukemia, tumor suppressor, proto-oncogenes, postnatal development
MeSH terms
Proto-Oncogene Mas, Animals, B-Lymphocytes, Carrier Proteins, DNA-Binding Proteins, Membrane Proteins, Mice, Inbred C57BL, Neoplasm Proteins, Nuclear Proteins, Receptors, Cell Surface, Repressor Proteins, Transcription Factors, Signal Transduction, Leukemia, T-Cell, Mice, Knockout, Lymphopoiesis, Mice, Receptor, Notch1

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