The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Skin-Resident Murine Dendritic Cell Subsets Promote Distinct and Opposing Antigen-Specific T Helper Cell Responses
Open accessAbstract
Summary Skin-resident dendritic cells (DC) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least 3 subsets of skin DC — Langerhans cells (LC), Langerin+ dermal DC (dDC), and classic dDC. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the generation of antigen-specific T helper-17 (Th17) cells but not for the generation of cytotoxic lymphocytes (CTL). In contrast, Langerin+ dDC are required for the generation of antigen specific CTL and Th1 cells. Langerin+ dDC also inhibited the ability of LC and classic DC to promote Th17 responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses.
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Metadata
- Authors
- Igyártó, B. Z., Haley, K., Ortner, D., Bobr, A., Gerami-Nejad, M., Edelson, B. T., Zurawski, S. M., Malissen, B., Zurawski, G., Berman, J., & Kaplan, D. H.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 35
- Issue
- 2
- Pages
- 260-272
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2118815108
- Cited by
- 435
- References
- 64
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Igyártó, B. Z., Haley, K., Ortner, D., Bobr, A., Gerami-Nejad, M., Edelson, B. T., Zurawski, S. M., Malissen, B., Zurawski, G., Berman, J., & Kaplan, D. H. (2011). Skin-Resident Murine Dendritic Cell Subsets Promote Distinct and Opposing Antigen-Specific T Helper Cell Responses. Immunity. https://doi.org/10.1016/j.immuni.2011.06.005
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