Cited by 45Cellular transport and secretionT-cell and B-cell ImmunologyCell Adhesion Molecules Research

A New Vampire Saga: The Molecular Mechanism of T Cell Trogocytosis

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Dopfer, Elaine Pashupati, Minguet, Susana, Schamel, Wolfgang W.A.·2011·Immunity

Abstract

In the current issue of Immunity, Martínez-Martín et al. (2011) describe the central supramolecular activation cluster (cSMAC) as a site of clathrin-independent T cell receptor (TCR) internalization and trogocytosis. Further, they identify small Rho GTPases TC21 and RhoG as key mediators of these processes.

Integrity signals

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Crossref · 10.1016/j.immuni.2011.08.004

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  • Trogocytosis is a non-apoptotic mechanism for rapid capture of membrane components and differs from phagocytosis, which involves engulfment and elimination of larger cellular structures (>1 μm).

    “Trogocytosis has been described in the immune system as a non-apoptotic mechanism for the rapid capture of membrane components and differs from phagocytosis, which involves the engulfment and elimination of larger cellular structures (> 1 µm)17–19.”

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Authors
Dopfer, E. P., Minguet, S., & Schamel, W. W. A.
Affiliations
Max Planck Institute of Immunobiology and Epigenetics (DE)
Corresponding author
Schamel, Wolfgang W.A.
Venue
Immunity
Publisher
Elsevier BV
Published
2011-08
Volume
35
Issue
2
Pages
151-153
ISSN
1074-7613 (ISSN-L)
OpenAlex
W1999184001
Cited by
45
References
10
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
FWCI
0.77
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
clathrin-independent endocytosis, Rho GTPases, TC21, RhoG, T cell activation, molecular mechanisms

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