A New Vampire Saga: The Molecular Mechanism of T Cell Trogocytosis
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In the current issue of Immunity, Martínez-Martín et al. (2011) describe the central supramolecular activation cluster (cSMAC) as a site of clathrin-independent T cell receptor (TCR) internalization and trogocytosis. Further, they identify small Rho GTPases TC21 and RhoG as key mediators of these processes.
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Trogocytosis is a non-apoptotic mechanism for rapid capture of membrane components and differs from phagocytosis, which involves engulfment and elimination of larger cellular structures (>1 μm).
“Trogocytosis has been described in the immune system as a non-apoptotic mechanism for the rapid capture of membrane components and differs from phagocytosis, which involves the engulfment and elimination of larger cellular structures (> 1 µm)17–19.”
From Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction (2018) · cites this paper as [17]
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- Authors
- Dopfer, E. P., Minguet, S., & Schamel, W. W. A.
- Affiliations
- Max Planck Institute of Immunobiology and Epigenetics (DE)
- Corresponding author
- Schamel, Wolfgang W.A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 35
- Issue
- 2
- Pages
- 151-153
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1999184001
- Cited by
- 45
- References
- 10
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- clathrin-independent endocytosis, Rho GTPases, TC21, RhoG, T cell activation, molecular mechanisms
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