What is trogocytosis and what is its purpose?
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Trogocytosis is a non-apoptotic mechanism for rapid capture of membrane components and differs from phagocytosis, which involves engulfment and elimination of larger cellular structures (>1 μm).
“Trogocytosis has been described in the immune system as a non-apoptotic mechanism for the rapid capture of membrane components and differs from phagocytosis, which involves the engulfment and elimination of larger cellular structures (> 1 µm)17–19.”
From Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction (2018) · cites this paper as [19]
Cites
The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges
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Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton
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TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells
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T cells down-modulate peptide-MHC complexes on APCs in vivo
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Self-citationAcquisition of Viral Receptor by NK Cells Through Immunological Synapse
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CAR T cells produced in vivo to treat cardiac injury
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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
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T cell Allorecognition Pathways in Solid Organ Transplantation
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“The aforementioned findings suggest that T cells might gain CD57 via trogocytosis [17,18], a process where membrane fragments are directly transferred between cells within a few minutes and are detectable on the recipient cells for a considerable period of time [19-21].”
Background
- Authors
- Joly, E., & Hudrisier, D.
- Affiliations
- Inserm (FR)
- Venue
- Nature Immunology
- Published
- 2003-09-01
- Volume
- 4
- Issue
- 9
- Pages
- 815-815
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1976681938
- Cited by
- 543
- References
- 6
- Citations by year
- 2026: 19 · 2025: 31 · 2024: 36 · 2023: 41 · 2022: 36 · 2021: 39 · 2020: 33 · 2019: 27 · 2018: 24 · 2017: 13 · 2016: 20 · 2015: 22 · 2014: 28 · 2013: 27 · 2012: 25
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- trogocytosis, immunological synapse, T cell receptor signaling, cytotoxic T lymphocytes, natural killer cells, antigen presentation
- MeSH terms
- Animals, Antigen-Presenting Cells, Cell Communication, Cell Membrane, Humans, Lymphocyte Activation, Lymphocytes
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