The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
Open accessAbstract
Summary The transcription factor GATA3 plays an essential role during T cell development and T helper 2 (Th2) cell differentiation. To understand GATA3-mediated gene regulation, we identified genome-wide GATA3 binding sites in ten well-defined developmental and effector T lymphocyte lineages. In the thymus, GATA3 directly regulated many critical factors, including Th-POK, Notch1 and T cell receptor subunits. In the periphery, GATA3 induced a large number of Th2 cell-specific as well as Th2 cell non-specific genes, including several transcription factors. Our data also indicate that GATA3 regulates both active and repressive histone modifications of many target genes at their regulatory elements near GATA3 binding sites. Overall, although GATA3 binding exhibited both shared and cell-specific patterns among various T cell lineages, many genes were either positively or negatively regulated by GATA3 in a cell type-specific manner, suggesting that GATA3-mediated gene regulation depends strongly on co-factors existing in different T cells.
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Cites
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Cited by
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GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
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Self-citationT-bet: a bridge between innate and adaptive immunity
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Metadata
- Authors
- Wei, G., Abraham, B. J., Yagi, R., Jothi, R., Cui, K., Sharma, S., Narlikar, L., Northrup, D. L., Tang, Q., Paul, W. E., Zhu, J., & Zhao, K.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 35
- Issue
- 2
- Pages
- 299-311
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1996835556
- Cited by
- 337
- References
- 43
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wei, G., Abraham, B. J., Yagi, R., Jothi, R., Cui, K., Sharma, S., Narlikar, L., Northrup, D. L., Tang, Q., Paul, W. E., Zhu, J., & Zhao, K. (2011). Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types. Immunity. https://doi.org/10.1016/j.immuni.2011.08.007
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