The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells
Open accessAbstract
SUMMARY Innate lymphoid cells (ILCs) are critical in innate immune responses to pathogens and lymphoid organ development. IL-7Rα + ILC subsets, similar to CD4+T helper (Th) cell subsets, produce distinct sets of effector cytokines. However, the molecular control of IL-7Rα + ILC development and maintenance is unclear. Here we report that GATA3 was indispensable for the development of all IL-7Rα + ILC subsets in addition to T cells, but not required for the development of classical NK cells. Gata3 conditional deficient mice had no lymph nodes and were susceptible to Citrobactor rodentium infection. After the ILCs have fully developed, GATA3 remained important for the maintenance and functions of ILC2s. Genome-wide gene expression analyses indicated that GATA3 regulated a similar set of cytokines and receptors in Th2 cells and ILC2s, but not in ILC3s. Thus, GATA3 plays parallel roles in regulating the development and functions of CD4+ T cells and IL-7Rα + ILCs.
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Cites
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696
Differentiation of Effector CD4 T Cell Populations
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Self-citationInnate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
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“CD4 T helper (Th) cells are central in orchestrating adaptive immune responses; distinct Th cell subsets are involved in protective immune responses to a variety of pathogens (Kanno et al., 2012; Zhu et al., 2010).”
Cited by
Innate lymphoid cells: A new paradigm in immunology
Eberl, G., Colonna, M., Di Santo, J. P., & McKenzie, A. N. J. (2015) · Science · doi:10.1126/science.aaa6566 · Cited by 878
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
Sonnenberg, G. F., & Artis, D. (2015) · Nature Medicine · doi:10.1038/nm.3892 · Cited by 503
Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway
Yu, Y., Tsang, J. C. H., Wang, C., Clare, S., Wang, J., Chen, X., Brandt, C., Kane, L., Campos, L. S., Lu, L., et al. (2016) · Nature · doi:10.1038/nature20105 · Cited by 306
Innate Lymphoid Cell Development: A T Cell Perspective
Cherrier, D. E., Serafini, N., & Di Santo, J. P. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.010 · Cited by 181
Fang, D., & Zhu, J. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20170494 · Cited by 175
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Metadata
- Authors
- Yagi, R., Zhong, C., Northrup, D. L., Yu, F., Bouladoux, N., Spencer, S., Hu, G., Barron, L., Sharma, S., Nakayama, T., Belkaid, Y., Zhao, K., & Zhu, J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 40
- Issue
- 3
- Pages
- 378-388
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2023719946
- Cited by
- 379
- References
- 6
- FWCI
- 18.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yagi, R., Zhong, C., Northrup, D. L., Yu, F., Bouladoux, N., Spencer, S., Hu, G., Barron, L., Sharma, S., Nakayama, T., Belkaid, Y., Zhao, K., & Zhu, J. (2014). The Transcription Factor GATA3 Is Critical for the Development of All IL-7Rα-Expressing Innate Lymphoid Cells. Immunity. https://doi.org/10.1016/j.immuni.2014.01.012
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