The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity
Open accessAbstract
Circadian rhythms refer to biologic processes that oscillate with a period of approximately 24 hours. These rhythms are sustained by a molecular clock and provide a temporal matrix that ensures the coordination of homeostatic processes with the periodicity of environmental challenges. We demonstrate the circadian molecular clock controls the expression and function of toll like receptor 9 (TLR9). In a vaccination model using TLR9 ligand as adjuvant, mice immunized at the time of enhanced TLR9 responsiveness presented weeks later with an improved adaptive immune response. In a TLR9-dependent mouse model of sepsis, we found that disease severity was dependent on the timing of sepsis induction, coinciding with the daily changes in TLR9 expression and function. These findings unveil a direct molecular link between the circadian and innate immune systems with important implications for immunoprophylaxis and immunotherapy.
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Citations
Cites
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
A circadian clock in macrophages controls inflammatory immune responses
Keller, M., Mazuch, J., Abraham, U., Eom, G. D., Herzog, E. D., Volk, H.-D., Kramer, A., & Maier, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906361106 · Cited by 843 · cited 2×
“For example, transcriptional analyses in resident peritoneal macrophages have revealed circadian fluctuations in several aspects of the TLR4-LPS response pathway (Keller et al., 2009).”
Zheng (1999) · doi:10.1038/22659 · Cited by 293
Susceptibility Rhythm to E. coli Endotoxin and Bioassay.
Halberg, F., Johnson, E. A., Brown, B. W., & Bittner, J. J. (1960) · Experimental Biology and Medicine · doi:10.3181/00379727-103-25439 · Cited by 280 · cited 2×
“In 1960, Halberg and colleagues reported that the mortality upon LPS-induced endotoxic shock in mice depends highly on the time of day when the mice are challenged, which further suggests that other immune response pathways triggered by pathogen recognition may be also subject to circadian control (Halberg et al., 196…”
Cited by
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449
Circadian control of the immune system
Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135
Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock
Asher, G., & Sassone-Corsi, P. (2015) · Cell · doi:10.1016/j.cell.2015.03.015 · Cited by 844
Mukherji, A., Kobiita, A., Ye, T., & Chambon, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.020 · Cited by 560
Metadata
- Authors
- Silver, A. C., Arjona, A., Walker, W. E., & Fikrig, E.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 36
- Issue
- 2
- Pages
- 251-261
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2010445256
- Cited by
- 437
- References
- 4
- FWCI
- 12.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Silver, A. C., Arjona, A., Walker, W. E., & Fikrig, E. (2012). The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity. Immunity. https://doi.org/10.1016/j.immuni.2011.12.017
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
