The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells
Open accessAbstract
Recent discoveries indicate that the skin of a normal individual contains 10-20 billion resident memory T cells ( which include various T helper, T cytotoxic, and T regulatory subsets, that are poised to respond to environmental antigens. Using only autologous human tissues, we report that both in vitro and in vivo, resting epidermal Langerhan cells (LC) selectively and specifically induced the activation and proliferation of skin resident regulatory T cells (Treg), a minor subset of skin resident memory T cells. In the presence of foreign pathogen, however, the same LC activated and induced proliferation of effector memory T (Tem) cells and limited Treg cells activation. These underappreciated properties of LC: namely maintenance of tolerance in normal skin, and activation of protective skin resident memory T cells upon infectious challenge, help clarify the role of LC in skin.
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Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
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Self-citation
Metadata
- Authors
- Seneschal, J., Clark, R. A., Gehad, A., Baecher-Allan, C. M., & Kupper, T. S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 36
- Issue
- 5
- Pages
- 873-884
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2074546623
- Cited by
- 455
- References
- 51
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Seneschal, J., Clark, R. A., Gehad, A., Baecher-Allan, C. M., & Kupper, T. S. (2012). Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells. Immunity. https://doi.org/10.1016/j.immuni.2012.03.018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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