The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy
Open accessAbstract
SUMMARY The mitochondrial protein MAVS (also known as IPS-1, VISA, CARDIF) interacts with RLR (RIG-I-like receptors) to induce type 1 interferon (IFN-I) during viral infection. NLRX1 is a mitochondrial NLR (nucleotide-binding, leucine-rich repeats containing) protein that attenuates MAVS-RLR signaling. Using Nlrx1−/− cells we confirmed NLRX1 attenuated IFN-I production, but additionally promoted autophagy during viral infection. This dual function of NLRX1 paralleled the previously described functions of the autophagy-related proteins Atg5-Atg12, but NLRX1 did not associate with Atg5-Atg12. High throughput quantitative mass spectrometry and endogenous protein-protein interaction revealed an NLRX1-interacting partner, mitochondrial Tu translation elongation factor (TUFM). TUFM interacted with Atg5-Atg12 and Atg16L1, and has similar functions as NLRX1 by inhibiting RLR-induced IFN-I but promoting autophagy. In the absence of NLRX1, increased IFN-I and decreased autophagy provide an advantage for host defense against vesicular stomatitis virus. This study establishes a link between an NLR protein and the viral-induced autophagic machinery via an intermediary partner, TUFM.
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Metadata
- Authors
- Lei, Y., Wen, H., Yu, Y., Taxman, D. J., Zhang, L., Widman, D. G., Swanson, K. V., Wen, K.-W., Damania, B., Moore, C. B., Giguère, P. M., Siderovski, D. P., Hiscott, J., Razani, B., Semenkovich, C. F., Chen, X., & Ting, J. P.-Y.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 36
- Issue
- 6
- Pages
- 933-946
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2070461642
- Cited by
- 295
- References
- 15
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lei, Y., Wen, H., Yu, Y., Taxman, D. J., Zhang, L., Widman, D. G., Swanson, K. V., Wen, K.-W., Damania, B., Moore, C. B., Giguère, P. M., Siderovski, D. P., Hiscott, J., Razani, B., Semenkovich, C. F., Chen, X., & Ting, J. P.-Y. (2012). The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy. Immunity. https://doi.org/10.1016/j.immuni.2012.03.025
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
