The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens
Open accessAbstract
SUMMARY Developing T cells express diverse antigen receptors whose specificities are not pre-matched to the foreign antigens they eventually encounter. Past experiments have revealed that thymocytes must productively signal in response to self-antigens to mature and enter the peripheral T cell pool (positive selection), but how this process enhances effective mature T cell responses to foreign antigen is not fully understood. Here we have documented an unsuspected connection between thymic recognition events and foreign antigen-driven T cell responses. We find that the strength of self-reactivity is a clone-specific property unexpectedly directly related to the strength of T cell receptor (TCR) binding to presented foreign antigen. T cells with receptors showing stronger interaction with self dominate in responses to infections and accumulate in aging individuals, revealing that positive selection contributes to effective immunity by skewing the mature TCR repertoire towards highly effective recognition of pathogens that pose a danger to the host.
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Metadata
- Authors
- Mandl, J. N., Monteiro, J. P., Vrisekoop, N., & Germain, R. N.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 38
- Issue
- 2
- Pages
- 263-274
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2161195685
- Cited by
- 304
- References
- 48
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mandl, J. N., Monteiro, J. P., Vrisekoop, N., & Germain, R. N. (2013). T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens. Immunity. https://doi.org/10.1016/j.immuni.2012.09.011
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