The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
Open accessAbstract
Summary Antibodies of the VRC01 class neutralize HIV-1, arise in diverse HIV-1-infected donors, and are potential templates for an effective HIV-1 vaccine. However, the stochastic processes that generate repertoires in each individual of >1012 antibodies make elicitation of specific antibodies uncertain. Here we determine the ontogeny of the VRC01 class by crystallography and next-generation sequencing. Despite antibody-sequence differences exceeding 50%, antibody-gp120 cocrystal structures reveal VRC01-class recognition to be remarkably similar. B cell transcripts indicate that VRC01-class antibodies require few specific genetic elements, suggesting that naive-B cells with VRC01-class features are generated regularly by recombination. Virtually all of these fail to mature, however, with only a few—likely one—ancestor B cell expanding to form a VRC01-class lineage in each donor. Developmental similarities in multiple donors thus reveal the generation of VRC01-class antibodies to be reproducible in principle, thereby providing a framework for attempts to elicit similar antibodies in the general population.
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Metadata
- Authors
- Zhou, T., Zhu, J., Wu, X., Moquin, S., Zhang, B., Acharya, P., Georgiev, I. S., Altae-Tran, H. R., Chuang, G.-Y., Joyce, M. G., Do Kwon, Y., Longo, N. S., Louder, M. K., Luongo, T., McKee, K., Schramm, C. A., Skinner, J., Yang, Y., Yang, Z., Zhang, Z., Zheng, A., Bonsignori, M., Haynes, B. F., Scheid, J. F., Nussenzweig, M. C., Simek, M., Burton, D. R., Koff, W. C., Mullikin, J. C., Connors, M., Shapiro, L., Nabel, G. J., Mascola, J. R., & Kwong, P. D.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 39
- Issue
- 2
- Pages
- 245-258
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2137603774
- Cited by
- 366
- References
- 5
- FWCI
- 15.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhou, T., Zhu, J., Wu, X., Moquin, S., Zhang, B., Acharya, P., Georgiev, I. S., Altae-Tran, H. R., Chuang, G.-Y., Joyce, M. G., Do Kwon, Y., Longo, N. S., Louder, M. K., Luongo, T., McKee, K., Schramm, C. A., Skinner, J., Yang, Y., Yang, Z., . . . Kwong, P. D. (2013). Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies. Immunity. https://doi.org/10.1016/j.immuni.2013.04.012
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