The promise and challenge of high-throughput sequencing of the antibody repertoire

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Germinal Centers

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Performance comparison of benchtop high-throughput sequencing platforms

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Detection and quantification of rare mutations with massively parallel sequencing

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A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

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Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells

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Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

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Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

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Therapeutic antibodies for autoimmunity and inflammation

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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

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Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities

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An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus

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Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

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The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

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Beyond natural antibodies: the power of in vitro display technologies

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Early Restriction of the Human Antibody Repertoire

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B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

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Autoreactivity in Human IgG+ Memory B Cells

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Broadly Neutralizing Antiviral Antibodies

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Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies

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Molecular programming of B cell memory

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Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

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Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

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High-Throughput Sequencing of the Zebrafish Antibody Repertoire

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Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia

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High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire

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Measurement and Clinical Monitoring of Human Lymphocyte Clonality by Massively Parallel V-D-J Pyrosequencing

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A Blueprint for HIV Vaccine Discovery

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Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

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Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis

Srivastava, R., Aslam, M., Kalluri, S. R., Schirmer, L., Buck, D., Tackenberg, B., Rothhammer, V., Chan, A., Gold, R., Berthele, A., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110740 · Cited by 344 · see citing works

Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination

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Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning

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Expressed Murine and Human CDR-H3 Intervals of Equal Length Exhibit Distinct Repertoires that Differ in their Amino Acid Composition and Predicted Range of Structures

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Evidence for a Large Compartment of IgM-Expressing Memory B Cells in Humans

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Maximum entropy models for antibody diversity

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B-cell tolerance checkpoints in health and autoimmunity

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Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells

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Microbial colonization influences early B-lineage development in the gut lamina propria

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High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations

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Digital RNA sequencing minimizes sequence-dependent bias and amplification noise with optimized single-molecule barcodes

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Advances in Human B Cell Phenotypic Profiling

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Convergent Antibody Signatures in Human Dengue

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B cell exchange across the blood-brain barrier in multiple sclerosis

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Individual Variation in the Germline Ig Gene Repertoire Inferred from Variable Region Gene Rearrangements

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Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine

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Rep‐Seq: uncovering the immunological repertoire through next‐generation sequencing

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Complete Haplotype Sequence of the Human Immunoglobulin Heavy-Chain Variable, Diversity, and Joining Genes and Characterization of Allelic and Copy-Number Variation

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Reshaping Antibody Diversity

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Genetic measurement of memory B-cell recall using antibody repertoire sequencing

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Evolutionary implications of a third lymphocyte lineage in lampreys

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High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions

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Thermostable group II intron reverse transcriptase fusion proteins and their use in cDNA synthesis and next-generation RNA sequencing

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High-Resolution Description of Antibody Heavy-Chain Repertoires in Humans

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Teleost Fish Mount Complex Clonal IgM and IgT Responses in Spleen upon Systemic Viral Infection

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Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies

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Quantifying selection in high-throughput Immunoglobulin sequencing data sets

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A proteomics approach for the identification and cloning of monoclonal antibodies from serum

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Limiting dilution analysis of the B cell compartment in human bone marrow

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Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation

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By-passing in vitro screening—next generation sequencing technologies applied to antibody display and in silico candidate selection

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High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment

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Addressing challenges in the production and analysis of illumina sequencing data

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Shaping of Human Germline IgH Repertoires Revealed by Deep Sequencing

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Similarity and divergence in the development and expression of the mouse and human antibody repertoires

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Tools to therapeutically harness the human antibody response

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NCBI GEO standards and services for microarray data

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Next generation sequencing for TCR repertoire profiling: Platform‐specific features and correction algorithms

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Antigen Receptor Allelic Exclusion: An Update and Reappraisal

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Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis

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Unifying immunology with informatics and multiscale biology

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Counting individual DNA molecules by the stochastic attachment of diverse labels

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Vaccination‐induced changes in human B‐cell repertoire and pneumococcal IgM and IgA antibody at different ages

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Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response

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Mining the antibodyome for HIV-1–neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

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Prize-based contests can provide solutions to computational biology problems

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Isolation of Human Antibody Repertoires with Preservation of the Natural Heavy and Light Chain Pairing

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