The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Origins and Functional Specialization of Macrophages and of Conventional and Monocyte-Derived Dendritic Cells in Mouse Skin
Open accessAbstract
In the skin, the lack of markers permitting the unambiguous identification of macrophages and of conventional and monocyte-derived dendritic cells (DCs) complicates understanding of their contribution to skin integrity and to immune responses. By combining CD64 and CCR2 staining, we successfully identified each of these cell types and studied their origin, transcriptomic signatures, and migratory and T cell stimulatory properties. We also analyzed the impact of microbiota on their development and their contribution to skin inflammation during contact hypersensitivity. Dermal macrophages had a unique scavenging role and were unable to migrate and activate T cells. Conventional dermal DCs excelled both at migrating and activating T cells. In the steady-state dermis, monocyte-derived DCs are continuously generated by extravasated Ly-6C(hi) monocytes. Their T cell stimulatory capacity combined with their poor migratory ability made them particularly suited to activate skin-tropic T cells. Therefore, a high degree of functional specialization occurs among the mononuclear phagocytes of the skin.
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“Macrophages, largely monocyte-derived in a CCR2-dependent manner [34], contribute to microbial uptake and clearance, cytokine production, and tissue homeostasis.”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [34]
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“Fibroblasts, though non-hematopoietic, also sense pathogens and secrete inflammatory mediators, highlighting the skin’s integrated immune-stromal cell network (see section below) [34–36].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [34]
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Cites
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Metadata
- Authors
- Tamoutounour, S., Guilliams, M., Montanana Sanchis, F., Liu, H., Terhorst, D., Malosse, C., Pollet, E., Ardouin, L., Luche, H., Sanchez, C., Dalod, M., Malissen, B., & Henri, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Malissen, Bernard
- Henri, Sandrine
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 39
- Issue
- 5
- Pages
- 925-938
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2091487793
- Semantic Scholar
- 635234bed33c89ab8095a4fc56cfec78ea9dbe11
- Cited by
- 783
- References
- 25
- Citations by year
- 2026: 22 · 2025: 25 · 2024: 53 · 2023: 63 · 2022: 63 · 2021: 68 · 2020: 72 · 2019: 71 · 2018: 75 · 2017: 93 · 2016: 66 · 2015: 64 · 2014: 46
- FWCI
- 32.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- European Commission (223404)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- dermal macrophages, myeloid dendritic cells, monocyte-derived dendritic cells, skin immune cells, monocyte origin, CD64, CCR2, Ly6C, T cell activation, dendritic cell migration, skin microbiome, contact hypersensitivity, skin inflammation, mononuclear phagocytes, gene expression signatures
- MeSH terms
- Animals, Antigens, Differentiation, Chemotaxis, Leukocyte, Chromatography, Gel, Dendritic Cells, Dermatitis, Contact, Langerhans Cells, Lymphocyte Cooperation, Macrophages, Monocytes, Radiation Chimera, Skin, Specific Pathogen-Free Organisms, Staining and Labeling, Immunophenotyping, Receptors, IgG, Gene Expression Regulation, Developmental, Cell Lineage, Dermis, Principal Component Analysis, CD11b Antigen, Mice, Receptors, CCR2, Transcriptome, Microbiota
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