The importance of cooperation: Partnerless NFAT induces T cell exhaustion

Molecular mechanisms of T cell co-stimulation and co-inhibition

Chen, L., & Flies, D. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3405 · Cited by 3,114 · see citing works

Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection

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The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

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NFAT, immunity and cancer: a transcription factor comes of age

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Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

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Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

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High antigen levels are the cause of T cell exhaustion during chronic viral infection

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The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

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T cell exhaustion during persistent viral infections

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4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection

Vezys, V., Penaloza‐MacMaster, P., Barber, D. L., Ha, S., Konieczny, B. T., Freeman, G. J., Mittler, R. S., & Ahmed, R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100077 · Cited by 99 · see citing works

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Elyahu, Y., Hekselman, I., Eizenberg-Magar, I., Berner, O., Strominger, I., Schiller, M., Mittal, K., Nemirovsky, A., Eremenko, E., Vital, A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw8330 · Cited by 324 · see citing works

T-cell Dysfunction in Glioblastoma: Applying a New Framework

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Improving CAR T-Cell Persistence

Pietrobon, V., Todd, L. A., Goswami, A., Stefanson, O., Yang, Z., & Marincola, F. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910828 · Cited by 118 · see citing works

T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy

Gao, Z., Feng, Y., Xu, J., & Liang, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.977394 · Cited by 111 · see citing works

B-cell receptor–mediated NFATc1 activation induces IL-10/STAT3/PD-L1 signaling in diffuse large B-cell lymphoma

Li, L., Zhang, J., Chen, J., Xu-Monette, Z. Y., Miao, Y., Xiao, M., Young, K. H., Wang, S., Medeiros, L. J., Wang, M. L., et al. (2018) · Blood · doi:10.1182/blood-2018-03-841015 · Cited by 97 · see citing works

NFAT signaling dysregulation in cancer: Emerging roles in cancer stem cells

Lin, Y., Song, Y., Zhang, Y., Shi, M., Hou, A., & Han, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115167 · Cited by 41 · see citing works

The chronicles of T-cell exhaustion

Amezquita, R. A., & Kaech, S. M. (2017) · Nature · doi:10.1038/nature21508 · Cited by 31 · see citing works

Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion

Balkhi, M. Y. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1747349 · Cited by 25 · see citing works

The molecular landscape of T cell exhaustion in the tumor microenvironment and reinvigoration strategies

Heidari‐Foroozan, M., Rezalotfi, A., & Rezaei, N. (2024) · International Reviews of Immunology · doi:10.1080/08830185.2024.2401352 · Cited by 18 · see citing works

Metabolic Regulation of CD8 + T Cells: From Mechanism to Therapy

Zheng, Y. Y., Wang, X., & Huang, M. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0040 · Cited by 18 · see citing works

Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation

Mohammadpour, H., Tsuji, T., MacDonald, C. R., Sarow, J. L., Rosenheck, H. R., Daneshmandi, S., Choi, J. E., Qiu, J., Matsuzaki, J., Witkiewicz, A. K., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112250 · Cited by 12 · see citing works

Regulation of CD19 CAR-T cell activation based on an engineered downstream transcription factor

Lainšček, D., Golob-Urbanc, A., Mikolič, V., Pantović-Žalig, J., Malenšek, Š., & Jerala, R. (2023) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2023.04.005 · Cited by 12 · see citing works

Guanylate binding protein 5 triggers NF-κB activation to foster radioresistance, metastatic progression and PD-L1 expression in oral squamous cell carcinoma

Chiu, H., Lin, C.-H., Lee, H., Lu, H.-W., Lin, Y.-H. K., Lin, Y., & Lee, H.-L. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.109892 · Cited by 11 · see citing works

Belatacept-related cytomegalovirus infection: Advocacy for tailored immunosuppression based on individual assessment of immune fitness

Zuber, J., Léon, J., Déchanet‐Merville, J., & Kaminski, H. (2024) · American Journal of Transplantation · doi:10.1016/j.ajt.2024.09.035 · Cited by 10 · see citing works

The role of NFAT in the pathogenesis and targeted therapy of hematological malignancies

Gao, R., Zhang, Y., Zeng, C., & Li, Y. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174889 · Cited by 9 · see citing works

Effects of potassium channel knockdown on peripheral blood T lymphocytes and NFAT signaling pathway in Xinjiang Kazak patients with hypertension

Dai, C., Tan, M., Meng, X., Dong, J., & Zhang, Y. (2023) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2023.2169449 · Cited by 9 · see citing works

HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells

Wang, H., Shi, Y., Zhou, X., Zhang, L., Yang, A., Zhou, D., & Ma, T. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09890-5 · Cited by 8 · see citing works

Decoding signaling architectures: CAR versus TCR dynamics in solid tumor immunotherapy

Chen, Z., & Zhou, X. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025190 · Cited by 4 · see citing works

The effect of NFATc1 on vascular generation and the possible underlying mechanism in epithelial ovarian carcinoma

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Theranostic Approaches for Pathway-Activated Systems in Oncology

Pham, L. V., Bryant, J. L., Yang, D. J., & Ford, R. J. (2017) · Springer eBooks · doi:10.1007/978-981-10-3349-0_2

Engineering T Cells with a Tumor-Reactive Chimeric T-cell Receptor Reduces Exhaustion and Promotes Persistence to Elicit Enhanced Antitumor Responses

Magno, J. C., Guo, J., Hall, S. C., Liu, J., Albert, G. K., Carter, J. D., Davalos, A. S., Cao, P., Bangar, A., Drigot, Z., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-25-0777

Cancer Immunotherapy: Therapeutic Limitations and Next-Generation Precision Strategies

Ko, D., Park, S., Nam, K.-H., Choi, J., & Lee, K. (2026) · Immune Network · doi:10.4110/in.2026.26.e31

Abstract IA02: The T cell ‘exhaustion’ transcriptional program downstream of NFAT

Hogan, P. G. (2026) · Cancer Immunology Research · doi:10.1158/2326-6074.io2026-ia02

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

Martinez, G. J., Pereira, R. M., Äijö, T., Kim, E. Y., Marangoni, F., Pipkin, M. E., Togher, S., Heissmeyer, V., Zhang, Y. C., Crotty, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.006 · Cited by 857 · see citing works

Understanding the role of NFAT2 transcription factors in T-cell Exhaustion

Ramchandani, P. (2020) · eScholarship (California Digital Library)

Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun

Macián, F., García‐Rodríguez, C., & Rao, A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4783 · Cited by 329 · see citing works

BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells

Seo, H., González‐Avalos, E., Zhang, W., Ramchandani, P., Yang, C., Lio, C. J., Rao, A., & Hogan, P. G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00964-8 · Cited by 353 · see citing works