The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow
Open accessAbstract
Antibody responses to viral infections are sustained for decades by long-lived plasma cells (LLPCs). However, LLPCs have yet to be characterized in humans. Here we used CD19, CD38, and CD138 to identify four PC subsets in human bone marrow (BM). We found that the CD19−CD38hiCD138+ subset was morphologically distinct, differentially expressed PC-associated genes and exclusively contained PCs specific for viral antigens to which the subjects had not been exposed for over 40 years. Protein sequences of measles- and mumps-specific circulating antibodies were encoded for by CD19−CD38hiCD138+ PCs in the BM. Finally, we found that CD19−CD38hiCD138+ PCs had a distinct RNA transcriptome signature and human immunoglobulin heavy chain (VH) repertoire that was relatively uncoupled from other BM PC subsets and likely represents the B cell response’s “historical record” of antigenic exposure. Thus, our studies define human LLPCs and provide a mechanism for the life-long maintenance of anti-viral antibodies in the serum.
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Cites
Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
Bernasconi, N. L., Traggiai, E., & Lanzavecchia, A. (2002) · Science · doi:10.1126/science.1076071 · Cited by 1,304
Duration of Humoral Immunity to Common Viral and Vaccine Antigens
Amanna, I. J., Carlson, N. E., & Slifka, M. K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066092 · Cited by 1,286
Self-citationPlasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals
Cassese, G., Arce, S., Hauser, A. E., Lehnert, K., Moewes, B., Mostarac, M., Muehlinghaus, G., Szyska, M., Radbruch, A., & Manz, R. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.4.1684 · Cited by 487
Cited by
Sanz, I., Wei, C., Jenks, S. A., Cashman, K. S., Tipton, C., Woodruff, M. C., Hom, J., & Lee, F. E.-H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02458 · Cited by 569
Self-citationGuidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens
Mina, M. J., Kula, T., Leng, Y., Li, M., de Vries, R. D., Knip, M., Siljander, H., Rewers, M., Choy, D. F., Wilson, M. S., et al. (2019) · Science · doi:10.1126/science.aay6485 · Cited by 466
The establishment of resident memory B cells in the lung requires local antigen encounter
Allie, S. R., Bradley, J. E., Mudunuru, U., Schultz, M. D., Graf, B. A., Lund, F. E., & Randall, T. D. (2019) · Nature Immunology · doi:10.1038/s41590-018-0260-6 · Cited by 396
Self-citationLiang, F., Lindgren, G., Lin, A., Thompson, E. A., Ols, S., Röhss, J., John, S., Hassett, K., Yuzhakov, O., Bahl, K., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.08.006 · Cited by 395
Metadata
- Authors
- Halliley, J. L., Tipton, C. M., Liesveld, J., Rosenberg, A. F., Darce, J., Gregoretti, I. V., Popova, L., Kaminiski, D., Fucile, C. F., Albizua, I., Kyu, S., Chiang, K.-Y., Bradley, K. T., Burack, R., Slifka, M., Hammarlund, E., Wu, H., Zhao, L., Walsh, E. E., Falsey, A. R., Randall, T. D., Cheung, W. C., Sanz, I., & Lee, F. E.-H.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 43
- Issue
- 1
- Pages
- 132-145
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1550723234
- Cited by
- 545
- References
- 3
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Halliley, J. L., Tipton, C. M., Liesveld, J., Rosenberg, A. F., Darce, J., Gregoretti, I. V., Popova, L., Kaminiski, D., Fucile, C. F., Albizua, I., Kyu, S., Chiang, K.-Y., Bradley, K. T., Burack, R., Slifka, M., Hammarlund, E., Wu, H., Zhao, L., Walsh, E. E., . . . Lee, F. E.-H. (2015). Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow. Immunity. https://doi.org/10.1016/j.immuni.2015.06.016
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
