Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens
Open accessAbstract
The toll of measles on the immune system: Many of the deaths attributable to measles virus are caused by secondary infections because the virus infects and functionally impairs immune cells. Whether measles infection causes long-term damage to immune memory has been unclear. This question has become increasingly important given the resurgence in measles epidemics worldwide. Using a blood test called VirScan, Mina et al. comprehensively analyzed the antibody repertoire in children before and after natural infection with measles virus as well as in children before and after measles vaccination. They found that measles infection can greatly diminish previously acquired immune memory, potentially leaving individuals at risk for infection by other pathogens. These adverse effects on the immune system were not seen in vaccinated children. Science , this issue p. 599
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Recent studies have indicated that measles disease casts a prolonged shadow over the immune system, with depletion of existing immune memory, such that children who have had the disease have an increased risk of death from other causes over the next few years.
“recent studies have indicated that measles disease casts a prolonged ‘shadow’ over the immune system, with depletion of existing immune memory, such that children who have had the disease have an increased risk of death from other causes over the next few years67,68.”
From A guide to vaccinology: from basic principles to new developments (2021) · cites this paper as [67]
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- Authors
- Mina, M. J., Kula, T., Leng, Y., Li, M., de Vries, R. D., Knip, M., Siljander, H., Rewers, M., Choy, D. F., Wilson, M. S., Larman, H. B., Nelson, A. N., Griffin, D. E., de Swart, R. L., & Elledge, S. J.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Department of Viroscience, Postgraduate School of Molecular Medicine, Erasmus MC, University Medical Centre Rotterdam, 3015 CN, Rotterdam, Netherlands.
- University of Helsinki (FI)
- University of Colorado Anschutz (US)
- Genentech (US)
- Johns Hopkins University (US)
- Corresponding author
- Mina, Michael J.
- Elledge, Stephen J.
- ORCID
- Venue
- Science
- Published
- 2019-11
- Volume
- 366
- Issue
- 6465
- Pages
- 599-606
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC8590458
- OpenAlex
- W2982502551
- Cited by
- 466
- References
- 42
- Citations by year
- 2026: 64 · 2025: 52 · 2024: 61 · 2023: 67 · 2022: 66 · 2021: 70 · 2020: 82 · 2019: 4
- FWCI
- 42.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- PubMed Central (acceptedVersion)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- National Institutes of Health (R21AI095981, R01 AI131228, U24AI118633)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK032493)
- Bill and Melinda Gates Foundation
- Genentech
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- measles virus, immunosuppression, antibody repertoire, cross-protection, MMR vaccination, unvaccinated children, macaque model
- MeSH terms
- Adolescent, Animals, Antibodies, Bacterial, Antibodies, Viral, Antibody Diversity, Epitopes, Child, Child, Preschool, Humans, Immune Tolerance, Immunologic Memory, Macaca mulatta, Male, Measles, Measles-Mumps-Rubella Vaccine
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