The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Complex Antigens Drive Permissive Clonal Selection in Germinal Centers
Open accessAbstract
SUMMARY Germinal center (GC) B cells evolve towards increased affinity by a Darwinian process that has been studied primarily in genetically restricted, hapten-specific responses. We explored the population dynamics of genetically diverse GC responses to two complex antigens – Bacillus anthracis protective antigen and influenza hemagglutinin – in which B cells competed both intra- and interclonally for distinct epitopes. Preferred VH rearrangements among antigen-binding, naïve B cells were similarly abundant in early GCs but, unlike responses to haptens, clonal diversity increased in GC B cells as early “winners” were replaced by rarer, high-affinity clones. Despite affinity maturation, inter- and intraclonal avidities varied greatly, and half of GC B cells did not bind the immunogen but nonetheless exhibited biased VH use, V(D)J mutation, and clonal expansion comparable to antigen-binding cells. GC reactions to complex antigens permit a range of specificities and affinities, with potential advantages for broad protection.
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Self-citationRapid cloning of high-affinity human monoclonal antibodies against influenza virus
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Cited by
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Human germinal centres engage memory and naive B cells after influenza vaccination
Turner, J. S., Zhou, J. Q., Han, J., Schmitz, A. J., Rizk, A. A., Alsoussi, W. B., Lei, T., Amor, M., McIntire, K. M., Meade, P., et al. (2020) · Nature · doi:10.1038/s41586-020-2711-0 · Cited by 304
Abbott, R. K., Lee, J. H., Menis, S., Skog, P., Rossi, M., Ota, T., Kulp, D. W., Bhullar, D., Kalyuzhniy, O., Havenar-Daughton, C., et al. (2018) · Immunity · doi:10.1016/j.immuni.2017.11.023 · Cited by 336
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Pantaleo, G., Correia, B., Fenwick, C., Joo, V. S., & Perez, L. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00495-3 · Cited by 279
Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo
Kato, Y., Abbott, R. K., Freeman, B. L., Haupt, S., Groschel, B., Silva, M., Menis, S., Irvine, D. J., Schief, W. R., & Crotty, S. (2020) · Immunity · doi:10.1016/j.immuni.2020.08.001 · Cited by 269
Metadata
- Authors
- Kuraoka, M., Schmidt, A. G., Nojima, T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S. C., Kepler, T. B., & Kelsoe, G.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 44
- Issue
- 3
- Pages
- 542-552
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2289890884
- Cited by
- 313
- References
- 40
- FWCI
- 17.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kuraoka, M., Schmidt, A. G., Nojima, T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S. C., Kepler, T. B., & Kelsoe, G. (2016). Complex Antigens Drive Permissive Clonal Selection in Germinal Centers. Immunity. https://doi.org/10.1016/j.immuni.2016.02.010
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