Human germinal centres engage memory and naive B cells after influenza vaccination
Open accessAbstract
Influenza viruses remain a major public health threat. Seasonal influenza vaccination in humans primarily stimulates pre-existing memory B cells, which differentiate into a transient wave of circulating antibody-secreting plasmablasts 1-3. This recall response contributes to 'original antigenic sin'-the selective increase of antibody species elicited by previous exposures to influenza virus antigens 4. It remains unclear whether such vaccination can also induce germinal centre reactions in the draining lymph nodes, where diversification and maturation of recruited B cells can occur 5. Here we used ultrasound-guided fine needle aspiration to serially sample the draining lymph nodes and investigate the dynamics and specificity of germinal centre B cell responses after influenza vaccination in humans. Germinal centre B cells that bind to influenza vaccine could be detected as early as one week after vaccination. In three out of eight participants, we detected vaccine-binding germinal centre B cells up to nine weeks after vaccination. Between 12% and 88% of the responding germinal centre B cell clones overlapped with B cells detected among early circulating plasmablasts. These shared B cell clones had high frequencies of somatic hypermutation and encoded broadly cross-reactive monoclonal antibodies. By contrast, vaccine-induced B cell clones detected only in the germinal centre compartment exhibited significantly lower frequencies of somatic hypermutation and predominantly encoded strain-specific monoclonal antibodies, which suggests a naive B cell origin. Some of these strain-specific monoclonal antibodies recognized epitopes that were not targeted by the early plasmablast response. Thus, influenza virus vaccination in humans can elicit a germinal centre reaction that recruits B cell clones that can target new epitopes, thereby broadening the spectrum of vaccine-induced protective antibodies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The detected plasmablasts were unlikely to be a contaminant of blood because CD14+ monocyte and/or granulocyte frequencies were below 1% in all FNA samples, below the 10% threshold previously established.
“The detected plasmablasts were unlikely to be a contaminant of blood, because CD14+ monocyte and/or granulocyte frequencies were below 1% in all FNA samples (well below the 10% threshold that was previously established19)”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [19]
Clones related to S-binding monoclonal antibodies had significantly increased mutation frequencies in IGHV genes compared to previously published naive B cells, particularly those related to cross-reactive monoclonal antibodies.
“Clones related to S-binding monoclonal antibodies had significantly increased mutation frequencies in their immunoglobulin heavy chain variable region (IGHV) genes compared to previously published naive B cells19, particularly those related to monoclonal antibodies that cross-reacted with seasonal betacoronaviruses”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [19]
Responses to mRNA vaccination are superior to those seen after seasonal influenza virus vaccination in humans, in whom haemagglutinin-binding germinal centre B cells were detected in only three out of eight participants.
“These responses to mRNA vaccination are superior to those seen after seasonal influenza virus vaccination in humans19, in whom haemagglutinin-binding germinal centre B cells were detected in only three out of eight participants.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [19]
These data are consistent with previous findings from seasonal influenza virus vaccination in humans that show that the germinal centre reaction can engage pre-existing memory B cells directed against conserved epitopes as well as naive clones targeting novel epitopes.
“These data are consistent with previous findings from seasonal influenza virus vaccination in humans that show that the germinal centre reaction can engage pre-existing memory B cells directed against conserved epitopes as well as naive clones targeting novel epitopes19.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [19]
The germinal centre responses after mRNA vaccination were superior to those seen after the seasonal influenza vaccination in humans.
“Furthermore, the germinal centre responses after mRNA vaccination were superior to those seen after the seasonal influenza vaccination in humans204.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [204]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
UCSF Chimera—A visualization system for exploratory research and analysis
Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., & Ferrin, T. E. (2004) · Journal of Computational Chemistry · doi:10.1002/jcc.20084 · Cited by 45,260 · see citing works
BLAST+: architecture and applications
Camacho, C., Coulouris, G., Avagyan, V., Ma, N., Papadopoulos, J., Bealer, K., & Madden, T. L. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-421 · Cited by 22,074 · see citing works
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453 · see citing works
RELION: Implementation of a Bayesian approach to cryo-EM structure determination
Scheres, S. H. W. (2012) · Journal of Structural Biology · doi:10.1016/j.jsb.2012.09.006 · Cited by 5,446 · see citing works
New tools for automated high-resolution cryo-EM structure determination in RELION-3
Zivanov, J., Nakane, T., Forsberg, B., Kimanius, D., Hagen, W., Lindahl, E., & Scheres, S. (2018) · eLife · doi:10.7554/elife.42166 · Cited by 4,377 · see citing works
circlize implements and enhances circular visualization in R
Gu, Z., Gu, L., Eils, R., Schlesner, M., & Brors, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu393 · Cited by 4,290 · see citing works
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
Iuliano, A. D., Roguski, K. M., Chang, H. H., Muscatello, D. J., Palekar, R. S., Tempia, S., Cohen, C., Gran, J. M., Schanzer, D. L., Cowling, B. J., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)33293-2 · Cited by 3,034 · see citing works
BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis
Durinck, S., Moreau, Y., Kasprzyk, A., Davis, S. R., Moor, B. D., Brāzma, A., & Huber, W. K. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti525 · Cited by 2,327 · see citing works
Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878 · see citing works
Automated molecular microscopy: The new Leginon system
Suloway, C. J. M., Pulokas, J., Fellmann, D., Cheng, A., Guerra, F., Quispe, J. D., Stagg, S. M., Potter, C. S., & Carragher, B. O. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.03.010 · Cited by 1,681 · see citing works
Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
Treutlein, B., Brownfield, D. G., Wu, A. R., Neff, N. F., Mantalas, G. L., Espinoza, F. H., Desai, T. J., Krasnow, M. A., & Quake, S. R. (2014) · Nature · doi:10.1038/nature13173 · Cited by 1,342 · see citing works
Corti, D., Voss, J., Gamblin, S. J., Codoni, G., Macagno, A., Jarrossay, D., Vachieri, S. G., Pinna, D., Minola, A., Vanzetta, F., et al. (2011) · Science · doi:10.1126/science.1205669 · Cited by 1,203 · see citing works
Yates, A. D., Achuthan, P., Akanni, W. A., Allen, J., Allen, J., Álvarez-Jarreta, J., Amode, M. R., Armean, I. M., Azov, A. G., Bennett, R., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz966 · Cited by 1,162 · see citing works
IgBLAST: an immunoglobulin variable domain sequence analysis tool
Ye, J., Ma, N., Madden, T., & Ostell, J. M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt382 · Cited by 1,161 · see citing works
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
Wrammert, J., Smith, K., Miller, J., Langley, W. A., Kokko, K. E., Larsen, C. P., Zheng, N., Mays, I., Garman, L., Helms, C., et al. (2008) · Nature · doi:10.1038/nature06890 · Cited by 1,026 · see citing works
Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data
Gupta, N. T., Heiden, J. A. V., Uduman, M., Gadala-Maria, D., Yaari, G., & Kleinstein, S. H. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv359 · Cited by 869 · see citing works
Self-citationAppion: An integrated, database-driven pipeline to facilitate EM image processing
Lander, G. C., Stagg, S. M., Voss, N. R., Cheng, A., Fellmann, D., Pulokas, J., Yoshioka, C., Irving, C., Mulder, A. M., Lau, P., et al. (2009) · Journal of Structural Biology · doi:10.1016/j.jsb.2009.01.002 · Cited by 836 · see citing works
Lefranc, M., Pommie, C., Ruíz, M., Giudicelli, V., Foulquier, E., Truong, L., Contet, V., & Lefranc, G. (2002) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(02)00039-3 · Cited by 823 · see citing works
Lefranc, M., Pommie, C., Kaas, Q., Duprat, É., Bosc, N., Guiraudou, D., Jean, C., Ruíz, M., da Piedade, I., Rouard, M., et al. (2004) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2004.07.003 · Cited by 808 · see citing works
Wrammert, J., Koutsonanos, D., Li, G., Edupuganti, S., Sui, J., Michael, M., McCausland, M. M., Skountzou, I., Hornig, M., Lipkin, W. I., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101352 · Cited by 777 · see citing works
Multiple layers of B cell memory with different effector functions
Dogan, I., Bertocci, B., Vilmont, V., Delbos, F., Mégret, J., Storck, S., Reynaud, C.-A., & Weill, J.-C. (2009) · Nature Immunology · doi:10.1038/ni.1814 · Cited by 635 · see citing works
Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response
Pape, K. A., Taylor, J. J., Maul, R. W., Gearhart, P. J., & Jenkins, M. K. (2011) · Science · doi:10.1126/science.1201730 · Cited by 572 · see citing works
IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
Giudicelli, V. (2004) · Nucleic Acids Research · doi:10.1093/nar/gki010 · Cited by 548 · see citing works
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1138 · Cited by 520 · see citing works
Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen
Smith, K., Garman, L., Wrammert, J., Zheng, N., Capra, J. D., Ahmed, R., & Wilson, P. C. (2009) · Nature Protocols · doi:10.1038/nprot.2009.3 · Cited by 471 · see citing works
Heiden, J. A. V., Yaari, G., Uduman, M., Stern, J. N. H., O’Connor, K. C., Hafler, D. A., Vigneault, F., & Kleinstein, S. H. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu138 · Cited by 469 · see citing works
Self-citationZuccarino-Catania, G., Sadanand, S., Weisel, F. J., Tomayko, M. M., Meng, H., Kleinstein, S. H., Good‐Jacobson, K. L., & Shlomchik, M. J. (2014) · Nature Immunology · doi:10.1038/ni.2914 · Cited by 444 · see citing works
Self-citationCorti, D., Suguitan, A. L., Pinna, D., Silacci, C., Fernandez-Rodriguez, B. M., Zatta, F., Santos, C. P., Luke, C. J., Torres-Velez, F. J., Temperton, N. J., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41902 · Cited by 437 · see citing works
Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.012 · Cited by 433 · see citing works
Self-citationEllebedy, A. H., Jackson, K., Kissick, H. T., Nakaya, H. I., Davis, C. W., Roskin, K. M., McElroy, A. K., Oshansky, C. M., Elbein, R., Thomas, S., et al. (2016) · Nature Immunology · doi:10.1038/ni.3533 · Cited by 384 · see citing works
Self-citationMesin, L., Schiepers, A., Ersching, J., Barbulescu, A., Cavazzoni, C. B., Angelini, A., Okada, T., Kurosaki, T., & Victora, G. D. (2019) · Cell · doi:10.1016/j.cell.2019.11.032 · Cited by 355 · see citing works
Complex Antigens Drive Permissive Clonal Selection in Germinal Centers
Kuraoka, M., Schmidt, A. G., Nojima, T., Feng, F., Watanabe, A., Kitamura, D., Harrison, S. C., Kepler, T. B., & Kelsoe, G. H. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.010 · Cited by 315 · see citing works
Structural and genetic basis for development of broadly neutralizing influenza antibodies
Lingwood, D., McTamney, P. M., Yassine, H. M., Whittle, J. R. R., Guo, X., Boyington, J. C., Wei, C., & Nabel, G. J. (2012) · Nature · doi:10.1038/nature11371 · Cited by 269 · see citing works
Broadly protective human antibodies that target the active site of influenza virus neuraminidase
Stadlbauer, D., Zhu, X., McMahon, M., Turner, J. S., Wohlbold, T. J., Schmitz, A. J., Strohmeier, S., Yu, W., Nachbagauer, R., Mudd, P. A., et al. (2019) · Science · doi:10.1126/science.aay0678 · Cited by 261 · see citing works
Self-citationEngineered immunogen binding to alum adjuvant enhances humoral immunity
Moyer, T. J., Kato, Y., Abraham, W. D., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0753-3 · Cited by 255 · see citing works
Self-citationBianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M. G., Bastidas, R. B., Nedellec, R., McCoy, L. E., Wilson, I. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.009 · Cited by 205 · see citing works
Self-citationGadala-Maria, D., Yaari, G., Uduman, M., & Kleinstein, S. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417683112 · Cited by 188 · see citing works
Self-citationHavenar‐Daughton, C., Carnathan, D. G., de la Peña, A. T., Pauthner, M. G., Briney, B. S., Reiss, S. M., Wood, J., Kaushik, K., van Gils, M. J., Rosales, S. L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.085 · Cited by 175 · see citing works
Margine, I., Palese, P., & Krammer, F. (2013) · Journal of Visualized Experiments · doi:10.3791/51112 · Cited by 169 · see citing works
Self-citationGupta, N. T., Adams, K., Briggs, A. W., Timberlake, S. C., Vigneault, F., & Kleinstein, S. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601850 · Cited by 159 · see citing works
Self-citationVallania, F., Tam, A., Lofgren, S., Schaffert, S. A., Azad, T. D., Bongen, E., Haynes, W. A., Alsup, M., Alonso, M. N., Davis, M. M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07242-6 · Cited by 158 · see citing works
Hoehn, K. B., Heiden, J. A. V., Zhou, J. Q., Lunter, G. A., Pybus, O. G., & Kleinstein, S. H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906020116 · Cited by 111 · see citing works
Self-citationNogal, B., Bianchi, M., Cottrell, C. A., Kirchdoerfer, R. N., Sewall, L. M., Turner, H. L., Zhao, F., Sok, D., Burton, D. R., Hangartner, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.061 · Cited by 89 · see citing works
Self-citationA Phylogenetic Codon Substitution Model for Antibody Lineages
Hoehn, K. B., Lunter, G. A., & Pybus, O. G. (2017) · Genetics · doi:10.1534/genetics.116.196303 · Cited by 77 · see citing works
Basic human anatomy : a regional study of human structure
O’Rahilly, R., & Müller, F. (1983) · Medical Entomology and Zoology · Cited by 74 · see citing works
Gilchuk, I. M., Bangaru, S., Gilchuk, P., Irving, R. P., Kose, N., Bombardi, R. G., Thornburg, N. J., Creech, C. B., Edwards, K. M., Li, S., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.10.003 · Cited by 69 · see citing works
Self-citationMeade, P. S., Kuan, G. M., Strohmeier, S., Maier, H. E., Amanat, F., Balmaseda, Á., Ito, K., Roubidoux, E. K., Javier, A., Gresh, L., et al. (2020) · mBio · doi:10.1128/mbio.03243-19 · Cited by 67 · see citing works
Self-citationRe-Engaging Cross-Reactive Memory B Cells: The Influenza Puzzle
Ellebedy, A. H., & Ahmed, R. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00053 · Cited by 55 · see citing works
Self-citationHavenar‐Daughton, C., Newton, I. G., Zare, S., Reiss, S. M., Schwan, B., Suh, M. J., Hasteh, F., Levi, G., & Crotty, S. (2020) · Journal of Immunological Methods · doi:10.1016/j.jim.2020.112746 · Cited by 50 · see citing works
Antiviral Activity of HIV gp120-Targeting Bispecific T Cell Engager Antibody Constructs
Brozy, J., Schlaepfer, E., Mueller, C. K. S., Rochat, M.-A., Rampini, S. K., Myburgh, R., Raum, T., Kufer, P., Baeuerle, P. A., Muenz, M., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00491-18 · Cited by 47 · see citing works
Cutting Edge: Ig H Chains Are Sufficient to Determine Most B Cell Clonal Relationships
Zhou, J. Q., & Kleinstein, S. H. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900666 · Cited by 47 · see citing works
Self-citationNachbagauer, R., Shore, D. A., Yang, H., Johnson, S. K., Gabbard, J. D., Tompkins, S. M., Wrammert, J., Wilson, P. C., Stevens, J., Ahmed, R., et al. (2018) · Journal of Virology · doi:10.1128/jvi.00949-18 · Cited by 38 · see citing works
Self-citationMeade, P. S., Latorre‐Margalef, N., Stallknecht, D. E., & Krammer, F. (2017) · Emerging Microbes & Infections · doi:10.1038/emi.2017.98 · Cited by 25 · see citing works
Self-citation
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [4]Francis T On the Doctrine of Original Antigenic Sin. Proc. Am. Philos. Soc 104, 572– 578 (1953).
Cited by
Sorted by citations
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555 · see citing works
Cell2location maps fine-grained cell types in spatial transcriptomics
Kleshchevnikov, V., Shmatko, A., Dann, E., Aivazidis, A., King, H. W., Li, T., Elmentaite, R., Lomakin, A., Kedlian, V., Gayoso, A., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01139-4 · Cited by 1,279 · see citing works
SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
Turner, J. S., O’Halloran, J. A., Kalaidina, E., Kim, W., Schmitz, A. J., Zhou, J. Q., Lei, T., Thapa, M., Chen, R. E., Case, J. B., et al. (2021) · Nature · doi:10.1038/s41586-021-03738-2 · Cited by 831 · see citing works
Self-citationVictora, G. D., & Nussenzweig, M. C. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-120419-022408 · Cited by 836 · see citing works
Goel, R. R., Apostolidis, S. A., Painter, M. M., Mathew, D., Pattekar, A., Kuthuru, O., Gouma, S., Hicks, P., Meng, W., Rosenfeld, A. M., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abi6950 · Cited by 655 · see citing works
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans
Turner, J. S., Kim, W., Kalaidina, E., Goss, C. W., Rauseo, A. M., Schmitz, A. J., Hansen, L., Haile, A., Klebert, M. K., Pusic, I., et al. (2021) · Nature · doi:10.1038/s41586-021-03647-4 · Cited by 515 · see citing works
Self-citationGerminal centre-driven maturation of B cell response to mRNA vaccination
Kim, W., Zhou, J. Q., Horvath, S. C., Schmitz, A. J., Sturtz, A. J., Lei, T., Liu, Z., Kalaidina, E., Thapa, M., Alsoussi, W. B., et al. (2022) · Nature · doi:10.1038/s41586-022-04527-1 · Cited by 345 · see citing works
Self-citationDesigning spatial and temporal control of vaccine responses
Roth, G. A., Picece, V. C. T. M., Ou, B. S., Luo, W., Pulendran, B., & Appel, E. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00372-2 · Cited by 328 · see citing works
Mudd, P. A., Minervina, A. A., Pogorelyy, M. V., Turner, J. S., Kim, W., Kalaidina, E., Petersen, J., Schmitz, A. J., Lei, T., Haile, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.12.026 · Cited by 302 · see citing works
Self-citationVaccination induces HIV broadly neutralizing antibody precursors in humans
Leggat, D. J., Cohen, K. W., Willis, J. R., Fulp, W. J., deCamp, A. C., Kalyuzhniy, O., Cottrell, C. A., Menis, S., Finak, G., Ballweber-Fleming, L., et al. (2022) · Science · doi:10.1126/science.add6502 · Cited by 285 · see citing works
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2
Amanat, F., Thapa, M., Lei, T., Ahmed, S. M. S., Adelsberg, D. C., Carreño, J. M., Strohmeier, S., Schmitz, A. J., Zafar, S., Zhou, J. Q., et al. (2021) · Cell · doi:10.1016/j.cell.2021.06.005 · Cited by 273 · see citing works
Self-citationMucosal immune responses to infection and vaccination in the respiratory tract
Mettelman, R. C., Allen, E. K., & Thomas, P. G. (2022) · Immunity · doi:10.1016/j.immuni.2022.04.013 · Cited by 272 · see citing works
The germinal centre B cell response to SARS-CoV-2
Laidlaw, B. J., & Ellebedy, A. H. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00657-1 · Cited by 250 · see citing works
Self-citationUnraveling B cell trajectories at single cell resolution
Morgan, D., & Tergaonkar, V. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.01.003 · Cited by 232 · see citing works
Immune responses to two and three doses of the BNT162b2 mRNA vaccine in adults with solid tumors
Shroff, R. T., Chalasani, P., Wei, R., Pennington, D., Quirk, G., Schoenle, M. V., Peyton, K. L., Uhrlaub, J. L., Ripperger, T. J., Jergović, M., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01542-z · Cited by 233 · see citing works
Inoue, T., & Kurosaki, T. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00897-3 · Cited by 227 · see citing works
Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes
Yu, Y., Chen, X., Pan, J., Ning, H., Zhang, Y., Bo, Y., Ren, X., Li, J., Qin, S., Wang, D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.06.038 · Cited by 219 · see citing works
A guide to adaptive immune memory
Lam, N., Lee, Y. S., & Färber, D. L. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01040-6 · Cited by 217 · see citing works
Molecular fate-mapping of serum antibody responses to repeat immunization
Schiepers, A., Wout, M. F. L. V. ’., Greaney, A. J., Zang, T. M., Muramatsu, H., Lin, P. J. C., Tam, Y. K., Mesin, L., Starr, T. N., Bieniasz, P. D., et al. (2023) · Nature · doi:10.1038/s41586-023-05715-3 · Cited by 166 · see citing works
SARS-CoV-2 Omicron boosting induces de novo B cell response in humans
Alsoussi, W. B., Malladi, S. K., Zhou, J. Q., Liu, Z., Ying, B., Kim, W., Schmitz, A. J., Lei, T., Horvath, S. C., Sturtz, A. J., et al. (2023) · Nature · doi:10.1038/s41586-023-06025-4 · Cited by 167 · see citing works
Self-citationMemory B cell repertoire for recognition of evolving SARS-CoV-2 spike
Tong, P., Gautam, A., Windsor, I., Travers, M., Chen, Y., Garcia, N., Whiteman, N. B., McKay, L. G. A., Storm, N., Malsick, L. E., et al. (2021) · Cell · doi:10.1016/j.cell.2021.07.025 · Cited by 86 · see citing works
“World in motion” – emulsion adjuvants rising to meet the pandemic challenges
O’Hagan, D. T., der Most, R. G. V., Lodaya, R. N., Coccia, M., & Lofano, G. (2021) · npj Vaccines · doi:10.1038/s41541-021-00418-0 · Cited by 121 · see citing works
Samanovic, M. I., Cornelius, A. R., Gray-Gaillard, S. L., Allen, J. R., Karmacharya, T., Wilson, J. P., Hyman, S., Tuen, M., Koralov, S. B., Mulligan, M. J., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abi8961 · Cited by 112 · see citing works
Human circulating and tissue-resident memory CD8+ T cells
Buggert, M., Price, D. A., Mackay, L. K., & Betts, M. R. (2023) · Nature Immunology · doi:10.1038/s41590-023-01538-6 · Cited by 119 · see citing works
Co-evolution of immunity and seasonal influenza viruses
Han, A. X., de Jong, S. P. J., & Russell, C. A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00945-8 · Cited by 108 · see citing works
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids
Kastenschmidt, J. M., Sureshchandra, S., Jain, A., Hernandez‐Davies, J. E., de Assis, R., Wagoner, Z. W., Sorn, A. M., Mitul, M. T., Benchorin, A. I., Levendosky, E., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.019 · Cited by 104 · see citing works
Vaccinology in the post−COVID-19 era
Rappuoli, R., Gregorio, E. D., Giudice, G. D., Phogat, S. K., Pecetta, S., Pizza, M., & Hanon, E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2020368118 · Cited by 96 · see citing works
Crickx, É., Chappert, P., Sokal, A., Weller, S., Azzaoui, I., Vandenberghe, A., Bonnard, G., Rossi, G., Fadeev, T., Storck, S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abc3961 · Cited by 97 · see citing works
Continuous germinal center invasion contributes to the diversity of the immune response
Hägglöf, T., Cipolla, M., Loewe, M., Chen, S. T., Kara, E. E., Mesin, L., Hartweger, H., ElTanbouly, M. A., Cho, A., Gazumyan, A., et al. (2022) · Cell · doi:10.1016/j.cell.2022.11.032 · Cited by 93 · see citing works
B-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity
Lapuente, D., Winkler, T., & Tenbusch, M. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01095-w · Cited by 91 · see citing works
Nellore, A., Zumaquero, E., Scharer, C. D., Fucile, C., Tipton, C. M., King, R. G., Tian, M., Mousseau, B. J., Bradley, J., Zhou, F., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.03.001 · Cited by 87 · see citing works
Kleshchevnikov, V., Shmatko, A., Dann, E., Aivazidis, A., King, H. W., Li, T., Lomakin, A., Kedlian, V. R., Jain, M. S., Park, J. S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.15.378125 · Cited by 88 · see citing works
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
Herati, R. S., Knorr, D. A., Vella, L. A., Silva, L. V., Chilukuri, L., Apostolidis, S. A., Huang, A. C. C., Muselman, A., Manne, S., Kuthuru, O., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01274-3 · Cited by 84 · see citing works
Nkongolo, S., Mahamed, D., Kuipery, A., Vásquez, J. D. S., Kim, S., Mehrotra, A., Patel, A. B., Hu, C., McGilvray, I. D., Feld, J. J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci158903 · Cited by 83 · see citing works
Schiepers, A., Wout, M. F. L. V. ’., Hobbs, A., Mesin, L., & Victora, G. D. (2024) · Immunity · doi:10.1016/j.immuni.2024.05.009 · Cited by 81 · see citing works
Guthmiller, J. J., Han, J., Li, L., Freyn, A. W., Liu, S. T. H., Stovicek, O., Stamper, C. T., Dugan, H. L., Tepora, M. E., Utset, H. A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abg4535 · Cited by 77 · see citing works
Self-citationGao, X., Shen, Q., Roco, J. A., Dalton, B., Frith, K., Munier, C. M. L., Ballard, F. D., Wang, K., Kelly, H. G., Nekrasov, M., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adj4748 · Cited by 78 · see citing works
Mechanisms underpinning poor antibody responses to vaccines in ageing
Lee, J. L., & Linterman, M. A. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.11.001 · Cited by 71 · see citing works
Transcriptional and Metabolic Control of Memory B Cells and Plasma Cells
Ripperger, T. J., & Bhattacharya, D. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-125603 · Cited by 70 · see citing works
Edahiro, R., Shirai, Y., Takeshima, Y., Sakakibara, S., Yamaguchi, Y., Murakami, T., Morita, T., Kato, Y., Liu, Y., Motooka, D., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01375-1 · Cited by 69 · see citing works
Cold-blooded vertebrates evolved organized germinal center–like structures
Shibasaki, Y., Afanasyev, S., Fernández-Montero, Á., Ding, Y., Watanabe, S., Takizawa, F., Lamas, J., Fontenla-Iglesias, F., Leiro, J. M., Krasnov, A., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adf1627 · Cited by 69 · see citing works
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases
Bhattacharya, D. (2022) · Immunity · doi:10.1016/j.immuni.2022.05.004 · Cited by 63 · see citing works
Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults
Kared, H., Wolf, A., Alirezaylavasani, A., Ravussin, A., Solum, G., Tran, T. T., Lund‐Johansen, F., Vaage, J. T., Nissen‐Meyer, L. S. H., Nygaard, U. C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31888-y · Cited by 65 · see citing works
The development and function of CD11c+ atypical B cells - insights from single cell analysis
Gao, X., & Cockburn, I. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.979060 · Cited by 65 · see citing works
BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2
Brewer, R., Ramadoss, N., Lahey, L., Jahanbani, S., Robinson, W., & Lanz, T. V. (2021) · Nature Immunology · doi:10.1038/s41590-021-01088-9 · Cited by 63 · see citing works
Recall of B cell memory depends on relative locations of prime and boost immunization
Kuraoka, M., Yeh, C., Bajic, G., Kotaki, R., Song, S., Windsor, I. W., Harrison, S. C., & Kelsoe, G. H. (2022) · Science Immunology · doi:10.1126/sciimmunol.abn5311 · Cited by 66 · see citing works
Damato, V., Theorell, J., Al‐Diwani, A., Kienzler, A., Makuch, M., Sun, B., Handel, A. E., Akdeniz, D., Berretta, A., Ramanathan, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2121804119 · Cited by 63 · see citing works
Mettelman, R. C., Souquette, A. H., de Velde, L.-A. V., Vegesana, K., Allen, E. K., Kackos, C. M., Trifkovic, S., DeBeauchamp, J., Wilson, T. L., James, D. G. S., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01590-2 · Cited by 62 · see citing works
Matsumoto, R., Gray, J. I., Rybkina, K., Oppenheimer, H., Levy, L., Friedman, L. M., Khamaisi, M., Meng, W., Rosenfeld, A. M., Guyer, R. S., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01557-3 · Cited by 62 · see citing works
Allen, J. D., & Ross, T. M. (2022) · Journal of Virology · doi:10.1128/jvi.01652-21 · Cited by 59 · see citing works
B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination
Kotagiri, P., Mescia, F., Rae, W. M., Bergamaschi, L., Tuong, Z. K., Turner, L., Hunter, K., Gerber, P. P., Hosmillo, M. D. T., Hess, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110393 · Cited by 58 · see citing works
Defining the balance between optimal immunity and immunopathology in influenza virus infection
Nguyen, T. H. O., Rowntree, L. C., Chua, B. Y. L., Thwaites, R. S., & Kedzierska, K. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01029-1 · Cited by 58 · see citing works
Predictive Markers of Immunogenicity and Efficacy for Human Vaccines
Tilbeurgh, M. V., Lemdani, K., Beignon, A., Chapon, C., Tchitchek, N., Cheraitia, L., López, E. M., Pascal, Q., Grand, R. L., Maisonnasse, P., et al. (2021) · Vaccines · doi:10.3390/vaccines9060579 · Cited by 58 · see citing works
B Cell Response to Vaccination
Luo, W., & Yin, Q. (2021) · Immunological Investigations · doi:10.1080/08820139.2021.1903033 · Cited by 52 · see citing works
B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat
Guthmiller, J. J., Utset, H. A., & Wilson, P. C. (2021) · Viruses · doi:10.3390/v13060965 · Cited by 52 · see citing works
Hoehn, K. B., Turner, J. S., Miller, F. I., Jiang, R., Pybus, O. G., Ellebedy, A. H., & Kleinstein, S. H. (2021) · eLife · doi:10.7554/elife.70873 · Cited by 48 · see citing works
Self-citationYewdell, W. T., Smolkin, R. M., Belcheva, K. T., Mendoza, A., Michaels, A. J., Cols, M., Angeletti, D., Yewdell, J. W., & Chaudhuri, J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109961 · Cited by 49 · see citing works
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection
Moga, E., Lynton‐Pons, E., & Domingo, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.904686 · Cited by 46 · see citing works
Reactive oxygen species associated immunoregulation post influenza virus infection
Wang, L., Cao, Z., Wang, Z., Guo, J., & Wen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.927593 · Cited by 49 · see citing works
González-Meljem, J. M., & Martı́nez-Barberá, J. P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03798-7 · Cited by 47 · see citing works
Plasma cell survival: The intrinsic drivers, migratory signals, and extrinsic regulators
Nguyen, D. C., Duan, M., Ali, M., Ley, A. M., Sanz, I., & Lee, F. E.-H. (2021) · Immunological Reviews · doi:10.1111/imr.13013 · Cited by 43 · see citing works
Lei, R., Kim, W., Lv, H., Mou, Z., Scherm, M. J., Schmitz, A. J., Turner, J. S., Tan, T. J. C., Wang, Y., Ouyang, W. O., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.10.005 · Cited by 45 · see citing works
Self-citationGeneration of High Quality Memory B Cells
Inoue, T., Shinnakasu, R., & Kurosaki, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.825813 · Cited by 43 · see citing works
The memory B cell response to influenza vaccination is impaired in older persons
Burton, A. R., Guillaume, S. M., Foster, W. S., Wheatley, A. K., Hill, D. L., Carr, E. J., & Linterman, M. A. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111613 · Cited by 44 · see citing works
Maturation of germinal center B cells after influenza virus vaccination in humans
McIntire, K. M., Meng, H., Lin, T.-H., Kim, W., Moore, N. E., Han, J., McMahon, M., Wang, M., Malladi, S. K., Mohammed, B. M., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20240668 · Cited by 40 · see citing works
Self-citationAntigenic drift expands influenza viral escape pathways from recalled humoral immunity
Maurer, D. P., Vu, M. L., & Schmidt, A. G. (2025) · Immunity · doi:10.1016/j.immuni.2025.02.006 · Cited by 42 · see citing works
Amanat, F., Thapa, M., Lei, T., Ahmed, S. M. S., Adelsberg, D. C., Carreño, J. M., Strohmeier, S., Schmitz, A. J., Zafar, S., Zhou, J. Q., et al. (2021) · medRxiv · doi:10.1101/2021.03.07.21253098 · Cited by 41 · see citing works
Self-citationMulè, M. P., Martins, A. J., Cheung, F., Farmer, R., Sellers, B. A., Quiel, J. A., Jain, A., Kotliarov, Y., Bansal, N., Chen, J., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.04.009 · Cited by 39 · see citing works
Borcherding, N. C., Kim, W., Quinn, M. A., Han, F., Zhou, J. Q., Sturtz, A. J., Schmitz, A. J., Lei, T., Schattgen, S., Klebert, M. K., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01888-9 · Cited by 38 · see citing works
Self-citationLoes, A. N., Tarabi, R. A. L., Huddleston, J., Touyon, L., Wong, S., Cheng, S. M. S., Leung, N., Hannon, W. W., Bedford, T., Cobey, S. E., et al. (2024) · Journal of Virology · doi:10.1128/jvi.00689-24 · Cited by 37 · see citing works
Influenza vaccination stimulates maturation of the human T follicular helper cell response
Schattgen, S., Turner, J. S., Ghonim, M. A., Crawford, J. C., Schmitz, A. J., Kim, H., Zhou, J. Q., Awad, W., Mettelman, R. C., Kim, W., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01926-6 · Cited by 36 · see citing works
Self-citationWindsor, I. W., Tong, P., Lavidor, O., Moghaddam, A. S., McKay, L. G. A., Gautam, A. K., Chen, Y., MacDonald, E. A., Yoo, D. K., Griffths, A., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abo3425 · Cited by 36 · see citing works
Phillips, A. M., Maurer, D. P., Brooks, C., Dupic, T., Schmidt, A. G., & Desai, M. M. (2023) · eLife · doi:10.7554/elife.83628 · Cited by 33 · see citing works
Alternative B Cell Differentiation During Infection and Inflammation
Courey‐Ghaouzi, A., Kleberg, L., & Sundling, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.908034 · Cited by 33 · see citing works
Maltseva, M., Keeshan, A., Cooper, C., & Langlois, M. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2384192 · Cited by 33 · see citing works
Conversion of vaccines from low to high immunogenicity by antibodies with epitope complementarity
Dvorscek, A. R., McKenzie, C. I., Stäheli, V. C., Ding, Z., White, J., Fabb, S. A., Lim, L., O’Donnell, K., Pitt, C., Christ, D., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.08.017 · Cited by 33 · see citing works
Sokal, A., Spaeth, G. B., Hunault, L., Fernández, I., Broketa, M., Meola, A., Fourati, S., Azzaoui, I., Vandenberghe, A., Lagouge-Roussey, P., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.07.007 · Cited by 34 · see citing works
Vaccination against rapidly evolving pathogens and the entanglements of memory
Cobey, S. E. (2024) · Nature Immunology · doi:10.1038/s41590-024-01970-2 · Cited by 35 · see citing works
Jacob-Dolan, C., Feldman, J. E., McMahan, K., Yu, J., Zahn, R. C., Wegmann, F., Schuitemaker, H., Schmidt, A. G., & Barouch, D. H. (2021) · Journal of Virology · doi:10.1128/jvi.00117-21 · Cited by 31 · see citing works
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
Lederer, K., Parvathaneni, K., Painter, M. M., Bettini, E., Agarwal, D., Lundgreen, K. A., Weirick, M., Goel, R. R., Xu, X., Drapeau, E. M., et al. (2021) · doi:10.1101/2021.09.16.21263686 · Cited by 179 · see citing works
Comparing the Cytokine Storms of COVID-19 and Pandemic Influenza
Pacheco-Hernández, L. M., Ramírez-Noyola, J. A., Gómez-García, I. A., Ignacio-Cortés, S., Zúñiga, J., & Choreño-Parra, J. A. (2022) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2022.0029 · Cited by 29 · see citing works
‘Persistent germinal center responses: slow-growing trees bear the best fruits’
Matz, H. C., McIntire, K. M., & Ellebedy, A. H. (2023) · Current Opinion in Immunology · doi:10.1016/j.coi.2023.102332 · Cited by 26 · see citing works
Self-citationT-follicular helper cells in malaria infection and roles in antibody induction
Soon, M. S. F., Nalubega, M., & Boyle, M. J. (2021) · Oxford Open Immunology · doi:10.1093/oxfimm/iqab008 · Cited by 27 · see citing works
Chardès, V., Vergassola, M., Walczak, A. M., & Mora, T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113512119 · Cited by 27 · see citing works
Scharf, L., Axelsson, H., Emmanouilidi, A., Mathew, N. R., Sheward, D. J., Leach, S., Isakson, P., Smirnov, I. V., Marklund, E., Miron, N., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.165299 · Cited by 27 · see citing works
Nielsen, C. M., Barrett, J. R., Wiggins, C. D., Fallon, J. K., Goh, C., Michell, A. R., Griffin, C., Kwok, A. J., Loos, C., Darko, S. W., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.163859 · Cited by 27 · see citing works
Nanovaccines for Advancing Long-Lasting Immunity against Infectious Diseases
Gao, X., Wang, X., Li, S., Rahman, M. S. U., Xu, S., & Liu, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c07741 · Cited by 26 · see citing works
B and T Cell Immunity in Tissues and Across the Ages
Booth, J. S., & Toapanta, F. R. (2021) · Vaccines · doi:10.3390/vaccines9010024 · Cited by 28 · see citing works
Evaluation of Next-Generation H3 Influenza Vaccines in Ferrets Pre-Immune to Historical H3N2 Viruses
Allen, J. D., & Ross, T. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.707339 · Cited by 26 · see citing works
Language model-based B cell receptor sequence embeddings can effectively encode receptor specificity
Wang, M., Patsenker, J., Li, H., Kluger, Y., & Kleinstein, S. H. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad1128 · Cited by 26 · see citing works
Self-citationRole of mucosal IgA antibodies as novel therapies to enhance mucosal barriers
Gao, P., Morita, N., & Shinkura, R. (2024) · Seminars in Immunopathology · doi:10.1007/s00281-024-01027-4 · Cited by 29 · see citing works
Delgado, K. N., Montezuma-Rusca, J. M., Orbe, I. C., Caimano, M. J., Vake, C. J. L., Luthra, A., Hennelly, C. M., Nindo, F. N., Meyer, J. W., Jones, L. D., et al. (2022) · mBio · doi:10.1128/mbio.01639-22 · Cited by 24 · see citing works
Memory B‐cell diversity: From early generation to tissue residency and reactivation
Reusch, L., & Angeletti, D. (2023) · European Journal of Immunology · doi:10.1002/eji.202250085 · Cited by 25 · see citing works
B cell phylogenetics in the single cell era
Hoehn, K. B., & Kleinstein, S. H. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.11.004 · Cited by 25 · see citing works
Self-citationYmir: A 3D structural affinity model for multi-epitope vaccine simulations
Robert, P. A., Arulraj, T., & Meyer‐Hermann, M. (2021) · iScience · doi:10.1016/j.isci.2021.102979 · Cited by 24 · see citing works
A practitioner’s view of spectral flow cytometry
Sharma, S. M., Boyer, J., & Teyton, L. (2023) · Nature Methods · doi:10.1038/s41592-023-02042-3 · Cited by 24 · see citing works
Gabernet, G., Marquez, S., Bjornson, R. D., Peltzer, A., Meng, H., Aron, E., Lee, N. Y., Jensen, C. G., Ladd, D., Polster, M., et al. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012265 · Cited by 23 · see citing works
Self-citationLaw, H. L., Mach, M., Howe, A., Obeid, S., Milner, B., Carey, C., Elfis, M., Fsadni, B., Ognenovska, K., Phan, T. G., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103656 · Cited by 23 · see citing works
Sarkkinen, J., Yohannes, D., Kreivi, N., Dürnsteiner, P., Elsakova, A., Huuhtanen, J., Nowlan, K., Kurdo, G., Lindén, R., Saarela, M., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adl3604 · Cited by 22 · see citing works
- Authors
- Turner, J. S., Zhou, J. Q., Han, J., Schmitz, A. J., Rizk, A. A., Alsoussi, W. B., Lei, T., Amor, M., McIntire, K. M., Meade, P., Strohmeier, S., Brent, R. I., Richey, S. T., Haile, A., Yang, Y. R., Klebert, M. K., Suessen, T., Teefey, S., Presti, R. M., Krammer, F., Kleinstein, S. H., Ward, A. B., & Ellebedy, A. H.
- Affiliations
- Washington University in St. Louis (US)
- Yale University (US)
- Scripps Research Institute (US)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Ellebedy, Ali H.
- ORCID
- Turner, Jackson S.
- Zhou, Julian Q.
- Han, Julianna
- Schmitz, Aaron J.
- Alsoussi, Wafaa B.
- Lei, Tingting
- McIntire, Katherine M.
- Meade, Philip
- Strohmeier, Shirin
- Brent, Rafael I.
- Richey, Sara T.
- Yang, Yuhe R.
- Klebert, Michael K.
- Teefey, Sharlene
- Presti, Rachel M.
- Krammer, Florian
- Kleinstein, Steven H.
- Ward, Andrew B.
- Ellebedy, Ali H.
- Venue
- Nature
- Published
- 2020-08-31
- Volume
- 586
- Issue
- 7827
- Pages
- 127-132
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7566073
- OpenAlex
- W3082694457
- Cited by
- 304
- References
- 54
- Citations by year
- 2026: 46 · 2025: 40 · 2024: 53 · 2023: 58 · 2022: 51 · 2021: 50 · 2020: 5 · 2019: 1
- FWCI
- 29.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000448, UL1TR002345)
- National Cancer Institute (T32CA009547, P30CA091842)
- National Institute of Allergy and Infectious Diseases (HHSN272201400008C), AI117287, R01AI128821, R01AI117287, R01AI104739, AI128821, R01AI104732, R56AI117287, 75N93019C00051, T32AI007244, R21AI139813, U01AI141990, U19AI089992, HHSN 272201400006C)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- influenza vaccination, germinal center, memory B cells, naive B cells, somatic hypermutation, original antigenic sin, plasmablasts, monoclonal antibodies, cross-reactive antibodies, strain-specific antibodies, draining lymph nodes, vaccine-induced antibody response
- MeSH terms
- Adult, Animals, B-Lymphocytes, Clone Cells, Female, Humans, Immunologic Memory, Influenza, Human, Influenza Vaccines, Male, Epitope Mapping, Germinal Center, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
