The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation
Open accessAbstract
Changes in metabolism can be initiated in response to signals received from other cells. An example of this is provided by macrophages that have been stimulated by IL-4 to become alternatively/M2 activated. In these cells, fatty acid oxidation is increased and this is critical for M2 activation. Compared to resting macrophages, M2 macrophages also exhibit changes in glucose metabolism that we have found are essential for activation. In other cell types, mTORC2 has been linked to enhanced glycolysis. We have found that mTORC2 operates in parallel with the IL-4Rα/Stat6 pathway to facilitate increased glycolysis during M2 activation. Our data strongly implicate PI3K and AKT signaling initiated by M-CSF as components in this pathway, and indicate that downstream induction of IRF4 expression plays a role in metabolic reprograming to support M2 activation. We show that loss of mTORC2 in macrophages suppresses tumor growth and decreases immunity to a parasitic nematode.
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Cites
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InfluentialTumor-Associated Macrophages: From Mechanisms to Therapy
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Cited by
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
Glaviano, A., Foo, A. S. C., Lam, H. Y., Yap, K. C. H., Jacot, W., Jones, R. H., Eng, H., Nair, M. G., Makvandi, P., Geoerger, B., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01827-6 · Cited by 2,138
The metabolic signature of macrophage responses
Viola, A., Munari, F., Sánchez-Rodríguez, R., Scolaro, T., & Castegna, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01462 · Cited by 2,021
α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
Liu, P.-S., Wang, H., Li, X., Chao, T., Teav, T., Christen, S., Di Conza, G., Cheng, W.-C., Chou, C.-H., Vavakova, M., et al. (2017) · Nature Immunology · doi:10.1038/ni.3796 · Cited by 1,264
Macrophage Immunometabolism: Where Are We (Going)?
Van den Bossche, J., O’Neill, L. A., & Menon, D. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.03.001 · Cited by 1,163
Targeting tumor-associated macrophages in cancer
Pathria, P., Louis, T. L., & Varner, J. A. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.02.003 · Cited by 933
Metadata
- Authors
- Huang, S. C.-C., Smith, A. M., Everts, B., Colonna, M., Pearce, E. L., Schilling, J. D., & Pearce, E. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 45
- Issue
- 4
- Pages
- 817-830
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2534854440
- Cited by
- 667
- References
- 47
- FWCI
- 25.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
- Funders
- NIH (AI110481, CA164062, CA18112502, P30 DK020579)
- NWO (VENI-91614087)
- Marie Curie (CIG-631585)
- American Heart Association (14POST20480221)
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- CoChat. (2026). Citation check: Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation. https://app.cochat.ai/papers/10.1016/j.immuni.2016.09.016
- The paper
- Huang, S. C.-C., Smith, A. M., Everts, B., Colonna, M., Pearce, E. L., Schilling, J. D., & Pearce, E. J. (2016). Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation. Immunity. https://doi.org/10.1016/j.immuni.2016.09.016
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
