The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis
Open accessAbstract
Neutrophils require directional cues to navigate through the complex structure of venular walls and into inflamed tissues. Here we applied confocal intravital microscopy to analyze neutrophil emigration in cytokine-stimulated mouse cremaster muscles. We identified differential and non-redundant roles for the chemokines CXCL1 and CXCL2, governed by their distinct cellular sources. CXCL1 was produced mainly by TNF-stimulated endothelial cells (ECs) and pericytes and supported luminal and sub-EC neutrophil crawling. Conversely, neutrophils were the main producers of CXCL2, and this chemokine was critical for correct breaching of endothelial junctions. This pro-migratory activity of CXCL2 depended on the atypical chemokine receptor 1 (ACKR1), which is enriched within endothelial junctions. Transmigrating neutrophils promoted a self-guided migration response through EC junctions, creating a junctional chemokine "depot" in the form of ACKR1-presented CXCL2 that enabled efficient unidirectional luminal-to-abluminal migration. Thus, CXCL1 and CXCL2 act in a sequential manner to guide neutrophils through venular walls as governed by their distinct cellular sources.
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The Chemokine Superfamily Revisited
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Leukocyte Migration into Inflamed Tissues
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Self-citationNeutrophil swarms require LTB4 and integrins at sites of cell death in vivo
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Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog
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Brain motor and fear circuits regulate leukocytes during acute stress
Poller, W. C., Downey, J., Mooslechner, A. A., Khan, N., Li, L., Chan, C. T., McAlpine, C. S., Xu, C., Kahles, F., He, S., et al. (2022) · Nature · doi:10.1038/s41586-022-04890-z · Cited by 234
Metadata
- Authors
- Girbl, T., Lenn, T., Perez, L., Rolas, L., Barkaway, A., Thiriot, A., del Fresno, C., Lynam, E., Hub, E., Thelen, M., Graham, G., Alon, R., Sancho, D., von Andrian, U. H., Voisin, M.-B., Rot, A., & Nourshargh, S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 49
- Issue
- 6
- Pages
- 1062-1076.e6
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2900736903
- Cited by
- 357
- References
- 40
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Girbl, T., Lenn, T., Perez, L., Rolas, L., Barkaway, A., Thiriot, A., del Fresno, C., Lynam, E., Hub, E., Thelen, M., Graham, G., Alon, R., Sancho, D., von Andrian, U. H., Voisin, M.-B., Rot, A., & Nourshargh, S. (2018). Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis. Immunity. https://doi.org/10.1016/j.immuni.2018.09.018
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