The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation
Open accessAbstract
The β common chain cytokines GM-CSF, IL-3 and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens, but also contribute to pathology in chronic inflammation. Some therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmune disease, and others show promising early clinical activity. These approaches are based on our understanding of the inflammatory roles of these cytokines; however, GM-CSF also participates in the resolution of inflammation and IL-3 and IL-5 may also have such properties. Here we review the functions of the β common cytokines in health and disease. We discuss pre-clinical and clinical data, highlighting the potential inherent in targeting these cytokine pathways, limitations, and the important gaps in understanding of the basic biology of this cytokine family.
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Self-citation
Metadata
- Authors
- Dougan, M., Dranoff, G., & Dougan, S. K.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 50
- Issue
- 4
- Pages
- 796-811
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2940004630
- Cited by
- 458
- References
- 157
- FWCI
- 15.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dougan, M., Dranoff, G., & Dougan, S. K. (2019). GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation. Immunity. https://doi.org/10.1016/j.immuni.2019.03.022
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
